Sandip Sengupta
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View article: Targeted autophagic clearance of Tau protects against Alzheimer's disease through amelioration of Tau-mediated lysosomal stress
Targeted autophagic clearance of Tau protects against Alzheimer's disease through amelioration of Tau-mediated lysosomal stress Open
Background: Lysosomal dysfunction could be an underlying cause of Alzheimer's disease, with Tau oligomer being an important inducer or amplifier of lysosomal stress associated with the disease. Tau oligomer is a well-known substrate of aut…
View article: Bacterial Microbial Defense Systems: From CRISPR-Cas Mechanisms to Emerging Anti-Phage Strategies
Bacterial Microbial Defense Systems: From CRISPR-Cas Mechanisms to Emerging Anti-Phage Strategies Open
Microorganisms inhabit diverse and often hostile environments, necessitating sophisticated defense mechanisms to survive predation, viral attacks, and competitive pressures. This delves into the array of defense systems employed by bacteri…
View article: Decoding Metabolic Pathway: Leveraging Computational Tools for Insight
Decoding Metabolic Pathway: Leveraging Computational Tools for Insight Open
His chapter introduces us to the role of cellular signaling pathways and their significance in understanding the intricate working of an organism’s functioning, life processes and enable us in deepening of our understanding of many disease…
View article: Microscopy-based Data Processing in Cell Biology
Microscopy-based Data Processing in Cell Biology Open
By making it possible to extract intricate and significant biological information from visual imaging, data processing based on microscopy has completely changed contemporary cell biology. Researchers have overcome historical constraints b…
View article: Bioactive Compounds - A New Era of Therapeutic Medicines
Bioactive Compounds - A New Era of Therapeutic Medicines Open
Bioactive compounds are secondary metabolites derived from plants. These secondary metabolites are present in plants, functioning in their metabolism and disease-resistance capacity. Herbal bioactive compounds are an emerging topic of rese…
View article: Zebrafish (Danio rerio) as a Model System for Diseases in Biological Studies
Zebrafish (Danio rerio) as a Model System for Diseases in Biological Studies Open
Background: Zebrafish (Danio rerio) are now a prime model organism in biomedical research due to their genetic similarity to humans, optical transparency in early development stages, and ability to be genetically manipulated with ease. Wit…
View article: Regulated Cell Death in Health and Disease: Emerging Mechanisms and Clinical Implications
Regulated Cell Death in Health and Disease: Emerging Mechanisms and Clinical Implications Open
Programmed cell death (PCD) is a tightly regulated biological process indispensable for preserving cellular homeostasis and directing tissue development. Perturbations in PCD pathways—including apoptosis, necroptosis, pyroptosis, ferroptos…
View article: Antibiotics and Their Mode of Action: A Comprehensive Review of Mechanisms and Resistance Pathways
Antibiotics and Their Mode of Action: A Comprehensive Review of Mechanisms and Resistance Pathways Open
Antibiotics are vital in combating infections by targeting bacteria and disrupting their growth. Understanding their various classes and modes of action helps us appreciate their role in healing. Bioremediation offers an environmentally fr…
View article: Decoding the Microbial World: An Introduction to Microbial Omics
Decoding the Microbial World: An Introduction to Microbial Omics Open
The microbial world is one of the most crucial parts of the ecosystem on Earth. It has a significant contribution to our human health along with several other organisms and the functioning of our environment. Genomics, transcriptomics, pro…
View article: Adjunctive Statistical Standardization of Adjuvant Estrogen Receptor and Progesterone Receptor in Canadian Cancer Trials Group MA.27 Postmenopausal Breast Cancer Trial of Exemestane Versus Anastrozole
Adjunctive Statistical Standardization of Adjuvant Estrogen Receptor and Progesterone Receptor in Canadian Cancer Trials Group MA.27 Postmenopausal Breast Cancer Trial of Exemestane Versus Anastrozole Open
PURPOSE ASCO/College of American Pathologists guidelines recommend reporting estrogen receptor (ER) and progesterone receptor (PgR) as positive with (1%-100%) staining. Statistically standardized quantitated positivity could indicate diffe…
View article: Comparative analysis of different cervical screening methods with special reference to the WHO recommended human papillomavirus detection at a rural tertiary care center - A pilot study
Comparative analysis of different cervical screening methods with special reference to the WHO recommended human papillomavirus detection at a rural tertiary care center - A pilot study Open
Background: Cervical cancer (Ca Cx) the 4th common cancer has a high mortality rate. Human Papilloma Virus (HPV) is chiefly responsible for a long latent period to progress from preinvasive to invasive Ca Cx. So it can be prevented by scre…
View article: Synthesis and antibacterial activities of baulamycin A inspired derivatives
Synthesis and antibacterial activities of baulamycin A inspired derivatives Open
SbnE is an essential enzyme for staphyloferrin B biosynthesis in Staphylococcus aureus. An earlier study showed that natural product baulamycin A has in vitro inhibitory activity against SbnE and antibacterial potency. A SAR study with ana…
View article: Figure S6 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Figure S6 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis Open
Ezrin protein expression after DOX and DTX drug challenge
View article: Figure S3 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Figure S3 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis Open
Automated analysis of pTERM staining in metastatic lesions and adjacent normal lung tissue
View article: Figure S5 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Figure S5 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis Open
Anti-ezrin treatment does not alter levels of circulating tumor cells in vivo
View article: Figure S2 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Figure S2 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis Open
Quantitation of exogenous Radixin and Moesin levels or knockdown by siRNA
View article: Figure S2 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Figure S2 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis Open
Quantitation of exogenous Radixin and Moesin levels or knockdown by siRNA
View article: Data from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Data from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis Open
The main cause of cancer-associated deaths is the spread of cancer cells to distant organs. Despite its success in the primary tumor setting, modern chemotherapeutic strategies are rendered ineffective at treating metastatic disease, large…
View article: Figure S5 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Figure S5 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis Open
Anti-ezrin treatment does not alter levels of circulating tumor cells in vivo
View article: Figure S1 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Figure S1 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis Open
Correlation analysis of ezrin levels with DOX or DTX sensitivity
View article: Figure S6 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Figure S6 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis Open
Ezrin protein expression after DOX and DTX drug challenge
View article: Figure S4 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Figure S4 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis Open
Assessment of microscopic metastasis and lung metastatic burden
View article: Figure S4 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Figure S4 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis Open
Assessment of microscopic metastasis and lung metastatic burden
View article: Figure S1 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Figure S1 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis Open
Correlation analysis of ezrin levels with DOX or DTX sensitivity
View article: Table S2 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Table S2 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis Open
Summary of IC50 values
View article: Data from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Data from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis Open
The main cause of cancer-associated deaths is the spread of cancer cells to distant organs. Despite its success in the primary tumor setting, modern chemotherapeutic strategies are rendered ineffective at treating metastatic disease, large…
View article: Table S1 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Table S1 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis Open
Common gene mutations or amplifications found in the BC cell line panel
View article: Table S3 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Table S3 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis Open
Drug synergy analysis of DOX or DTX in combination with NSC