Sandipto Sarkar
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View article: Gastric Cancer Tumor Immune Microenvironment Landscape: Clinical Implications for Patient Outcome and Response to PD-1 Immune Checkpoint Blockade
Gastric Cancer Tumor Immune Microenvironment Landscape: Clinical Implications for Patient Outcome and Response to PD-1 Immune Checkpoint Blockade Open
Although gastric cancer (GC) may be classified into molecular subtypes based on the TCGA1 or ACRG2 classification, the tumor immune microenvironment (TME) remains under-evaluated in both systems. Using unsupervised clustering of gene expre…
View article: 586 Phase II study of Telomelysin (OBP-301) in combination with pembrolizumab in gastroesophageal (GEA) adenocarcinoma
586 Phase II study of Telomelysin (OBP-301) in combination with pembrolizumab in gastroesophageal (GEA) adenocarcinoma Open
Background OBP-301 is a novel, oncolytic adenovirus that incorporates the human telomerase reverse transcriptase promoter for replication selectivity. As a single agent, OBP-301 demonstrated immune responses and clinical activity in phase …
View article: Data from CYR61/CCN1 Regulates dCK and CTGF and Causes Gemcitabine-resistant Phenotype in Pancreatic Ductal Adenocarcinoma
Data from CYR61/CCN1 Regulates dCK and CTGF and Causes Gemcitabine-resistant Phenotype in Pancreatic Ductal Adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) develops extrinsic- and intrinsic-resistant phenotypes to prevent chemotherapies from entering into the cells by promoting desmoplastic reactions (DR) and metabolic malfunctions of the drugs. It is w…
View article: Figures S1-S7 from CYR61/CCN1 Regulates dCK and CTGF and Causes Gemcitabine-resistant Phenotype in Pancreatic Ductal Adenocarcinoma
Figures S1-S7 from CYR61/CCN1 Regulates dCK and CTGF and Causes Gemcitabine-resistant Phenotype in Pancreatic Ductal Adenocarcinoma Open
Fig. S1. Detection of cross-reactivity of Cyr61 and CTGF antibodies; Fig. S2. CYR61 ablation in AsPC-1 Cell Line using CRISPR/Cas9 Gene Editing; Fig. S3. Knockdown of CYR61 in Panc-1 cells and AsPC-1 cells using stable transfection of shRN…
View article: Data from CYR61/CCN1 Regulates dCK and CTGF and Causes Gemcitabine-resistant Phenotype in Pancreatic Ductal Adenocarcinoma
Data from CYR61/CCN1 Regulates dCK and CTGF and Causes Gemcitabine-resistant Phenotype in Pancreatic Ductal Adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) develops extrinsic- and intrinsic-resistant phenotypes to prevent chemotherapies from entering into the cells by promoting desmoplastic reactions (DR) and metabolic malfunctions of the drugs. It is w…
View article: Figures S1-S7 from CYR61/CCN1 Regulates dCK and CTGF and Causes Gemcitabine-resistant Phenotype in Pancreatic Ductal Adenocarcinoma
Figures S1-S7 from CYR61/CCN1 Regulates dCK and CTGF and Causes Gemcitabine-resistant Phenotype in Pancreatic Ductal Adenocarcinoma Open
Fig. S1. Detection of cross-reactivity of Cyr61 and CTGF antibodies; Fig. S2. CYR61 ablation in AsPC-1 Cell Line using CRISPR/Cas9 Gene Editing; Fig. S3. Knockdown of CYR61 in Panc-1 cells and AsPC-1 cells using stable transfection of shRN…
View article: Multicenter Phase II Study of Cabazitaxel in Advanced Gastroesophageal Cancer: Association of HER2 Expression and M2-Like Tumor-Associated Macrophages with Patient Outcome
Multicenter Phase II Study of Cabazitaxel in Advanced Gastroesophageal Cancer: Association of HER2 Expression and M2-Like Tumor-Associated Macrophages with Patient Outcome Open
Purpose: We examined cabazitaxel, a novel next-generation taxoid, in patients with metastatic gastric cancer in a multicenter phase II study. Patients and Methods: Patients who have progressed on one or more prior therapies for locally adv…
View article: CYR61/CCN1 Regulates dCK and CTGF and Causes Gemcitabine-resistant Phenotype in Pancreatic Ductal Adenocarcinoma
CYR61/CCN1 Regulates dCK and CTGF and Causes Gemcitabine-resistant Phenotype in Pancreatic Ductal Adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) develops extrinsic- and intrinsic-resistant phenotypes to prevent chemotherapies from entering into the cells by promoting desmoplastic reactions (DR) and metabolic malfunctions of the drugs. It is w…
View article: MIND model for triple-negative breast cancer in syngeneic mice for quick and sequential progression analysis of lung metastasis
MIND model for triple-negative breast cancer in syngeneic mice for quick and sequential progression analysis of lung metastasis Open
Mouse models of breast cancer with specific molecular subtypes (e.g., ER or HER2 positive) in an immunocompetent or an immunocompromised environment significantly contribute to our understanding of cancer biology, despite some limitations,…
View article: The MAZ transcription factor is a downstream target of the oncoprotein Cyr61/CCN1 and promotes pancreatic cancer cell invasion via CRAF–ERK signaling
The MAZ transcription factor is a downstream target of the oncoprotein Cyr61/CCN1 and promotes pancreatic cancer cell invasion via CRAF–ERK signaling Open
Myc-associated zinc-finger protein (MAZ) is a transcription factor with dual roles in transcription initiation and termination. Deregulation of MAZ expression is associated with the progression of pancreatic ductal adenocarcinoma (PDAC). H…
View article: Roles of CCN5 in regulating progression and therapeutic sensitivity of breast cancer
Roles of CCN5 in regulating progression and therapeutic sensitivity of breast cancer Open
Breast cancer is one of the deadliest malignancies worldwide and also in the United States. Patients with triple negative breast cancer (TNBC), where the cancer cells do not express nuclear hormone receptors and human epidermal growth fact…
View article: CCN5/WISP-2 restores ER-∝ in normal and neoplastic breast cells and sensitizes triple negative breast cancer cells to tamoxifen
CCN5/WISP-2 restores ER-∝ in normal and neoplastic breast cells and sensitizes triple negative breast cancer cells to tamoxifen Open
CCN5/WISP-2 is an anti-invasive molecule and prevents breast cancer (BC) progression. However, it is not well understood how CCN5 prevents invasive phenotypes of BC cells. CCN5 protein expression is detected in estrogen receptor-α (ER-α) -…
View article: Loss of doublecortin (DCX) domain containing protein causes structural defects in tubulin-based organelle of Toxoplamsa gondii and impairs host cell invastion
Loss of doublecortin (DCX) domain containing protein causes structural defects in tubulin-based organelle of Toxoplamsa gondii and impairs host cell invastion Open
Available from: Nagayasu, E., Hwang, Y., Liu, J., Murray, J., & Hu, K. (2016). Loss of a doublecortin (DCX) domain containing protein causes structural defects in a tubulin-based organelle ofToxoplasma gondiiand impairs host cell invasion.…
View article: Human pancreatic cancer progression: an anarchy among CCN-siblings
Human pancreatic cancer progression: an anarchy among CCN-siblings Open
Decades of basic and translational studies have identified the mechanisms by which pancreatic cancer cells use molecular pathways to hijack the normal homeostasis of the pancreas, promoting pancreatic cancer initiation, progression, and me…
View article: Exosomes in carcinogenesis: molecular palkis carry signals for the regulation of cancer progression and metastasis
Exosomes in carcinogenesis: molecular palkis carry signals for the regulation of cancer progression and metastasis Open
Exosomes, which act as biological cargo vessels, are cell-released, phospholipid-enclosed vesicles. In eukaryotic cells, exosomes carry and exchange biological materials or signals for the benefit or detriment to the cells. Thereby, we con…