Sandra Atlante
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View article: Non-coding RNAs as novel biomarkers and therapeutic targets in breast cancer
Non-coding RNAs as novel biomarkers and therapeutic targets in breast cancer Open
Breast cancer (BC) remains a leading cause of cancer-related morbidity and mortality worldwide. Its marked heterogeneity - encompassing molecular subtypes, histological characteristics, and variable therapeutic responses - continues to pos…
View article: Cancer metabolism rewiring and chromatin methylation: a vulnerable epi-metabolic link
Cancer metabolism rewiring and chromatin methylation: a vulnerable epi-metabolic link Open
Over the past few years, significant advances have been made in understanding the crosstalk between cancer metabolism and gene expression. Whereas higher levels of expression of metabolic enzymes may be considered a conceivable compensator…
View article: Additional Cover
Additional Cover Open
Cover legend: The cover image is based on the article A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties by Sandra Atlante et al., https://doi.org/10.1111/acel.70047. [Image: see text]
View article: Senolytic therapies for cardiovascular aging: tackling fibrosis and metabolic dysfunction
Senolytic therapies for cardiovascular aging: tackling fibrosis and metabolic dysfunction Open
Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality, with aging as a critical risk factor. Cellular senescence, marked by irreversible cell cycle arrest and a pro-inflammatory secretory phenotype, drives age-rel…
View article: Correction to: The COVID‑19 legacy: consequences for the human DNA methylome and therapeutic perspectives
Correction to: The COVID‑19 legacy: consequences for the human DNA methylome and therapeutic perspectives Open
View article: A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties
A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties Open
The accumulation of senescent cells contributes to aging and related diseases; therefore, discovering safe senolytic agents—compounds that selectively eliminate senescent cells—is a critical priority. Heat shock protein 90 (HSP90) inhibito…
View article: The COVID-19 legacy: consequences for the human DNA methylome and therapeutic perspectives
The COVID-19 legacy: consequences for the human DNA methylome and therapeutic perspectives Open
View article: HDAC6 inhibition disrupts HDAC6-P300 interaction reshaping the cancer chromatin landscape
HDAC6 inhibition disrupts HDAC6-P300 interaction reshaping the cancer chromatin landscape Open
Background Histone deacetylases (HDACs) are crucial regulators of gene expression, DNA synthesis, and cellular processes, making them essential targets in cancer research. HDAC6, specifically, influences protein stability and chromatin dyn…
View article: The epigenomic consequences of HDAC6 inactivation reveal a crucial role for P300 suggesting integrated epitherapeutic strategies
The epigenomic consequences of HDAC6 inactivation reveal a crucial role for P300 suggesting integrated epitherapeutic strategies Open
Background : Histone deacetylases (HDACs) play a pivotal role in gene regulation, DNA synthesis, and cellular metabolism, significantly influencing cancer development. Class IIb histone deacetylase 6 (HDAC6) is crucial in maintaining prote…
View article: Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Distinguishable DNA methylation defines a cardiac-specific epigenetic clock Open
Background The present study investigates whether epigenetic differences emerge in the heart of patients undergoing cardiac surgery for an aortic valvular replacement (AVR) or coronary artery bypass graft (CABG). An algorithm is also estab…
View article: Distinguishable DNA Methylation Defines a Cardiac-Specific Epigenetic Clock
Distinguishable DNA Methylation Defines a Cardiac-Specific Epigenetic Clock Open
BACKGROUND The present study investigates whether epigenetic differences emerge in the heart of patients undergoing cardiac surgery for an aortic valvular replacement (AVR) or coronary artery bypass graft (CABG). An algorithm is also estab…
View article: Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors
Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors Open
The SARS-CoV-2 infection determines the COVID-19 syndrome characterized, in the worst cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokine release, and immunosuppression. This condition has led to th…
View article: EVIDENCE FOR BIOLOGICAL AGE ACCELERATION AND TELOMERE SHORTENING IN COVID19 SURVIVORS
EVIDENCE FOR BIOLOGICAL AGE ACCELERATION AND TELOMERE SHORTENING IN COVID19 SURVIVORS Open
Introduction & Background the SARS-CoV-2 infection determines the COVID19 syndrome characterized, in the worst cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokines release, and immunosuppression. Th…
View article: Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases
Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases Open
The WHO estimated around 41 million deaths worldwide each year for age-related non-communicable chronic diseases. Hence, developing strategies to control the accumulation of cell senescence in living organisms and the overall aging process…
View article: The epigenetic implication in coronavirus infection and therapy
The epigenetic implication in coronavirus infection and therapy Open
Epigenetics is a relatively new field of science that studies the genetic and non-genetic aspects related to heritable phenotypic changes, frequently caused by environmental and metabolic factors. In the host, the epigenetic machinery can …
View article: Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases
Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases Open
RNA epigenetics is perhaps the most recent field of interest for translational epigeneticists. RNA modifications create such an extensive network of epigenetically driven combinations whose role in physiology and pathophysiology is still f…
View article: Epigenetic Signalling and RNA Regulation in Cardiovascular Diseases
Epigenetic Signalling and RNA Regulation in Cardiovascular Diseases Open
RNA epigenetics is perhaps the most recent aspect of interest for translational epigeneticists. RNA modifications create such an extensive network of epigenetically driven combination whose role in physiology and pathophysiology is still f…
View article: P300/CBP‐associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation
P300/CBP‐associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation Open
The epigenetic enzyme p300/CBP‐associated factor (PCAF) belongs to the GCN5‐related N ‐acetyltransferase (GNAT) family together with GCN5. Although its transcriptional and post‐translational function is well characterized, little is known …
View article: α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis
α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis Open
View article: Structural and biological characterization of new hybrid drugs joining an HDAC inhibitor to different NO-donors
Structural and biological characterization of new hybrid drugs joining an HDAC inhibitor to different NO-donors Open
View article: Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health
Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health Open
View article: Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type2 Diabetes Patients
Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type2 Diabetes Patients Open
Rationale: Human cardiac mesenchymal cells (CMSCs) are a therapeutically relevant primary cell population. Diabetes mellitus compromises CMSC function as consequence of metabolic alterations and incorporation of stable epigenetic changes. …
View article: The double life of cardiac mesenchymal cells: Epimetabolic sensors and therapeutic assets for heart regeneration
The double life of cardiac mesenchymal cells: Epimetabolic sensors and therapeutic assets for heart regeneration Open
View article: Design and synthesis of <i>N</i>‐benzoyl amino acid derivatives as <scp>DNA</scp> methylation inhibitors
Design and synthesis of <i>N</i>‐benzoyl amino acid derivatives as <span>DNA</span> methylation inhibitors Open
The inhibition of human DNA Methyl Transferases ( DNMT ) is a novel promising approach to address the epigenetic dysregulation of gene expression in different diseases. Inspired by the validated virtual screening hit NSC 137546, a series o…