Sandra B. Hake
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View article: ZNF512B associates with mitotic spindles, regulates metaphase exit and is crucial for stem cell differentiation
ZNF512B associates with mitotic spindles, regulates metaphase exit and is crucial for stem cell differentiation Open
Zinc finger proteins are a large family of DNA-binding factors that play key roles in diverse cellular processes including gene regulation, RNA metabolism and cell cycle control. The zinc finger protein ZNF512B has recently been implicated…
View article: The “Ins and Outs and What-Abouts” of H2A.Z: A tribute to C. David Allis
The “Ins and Outs and What-Abouts” of H2A.Z: A tribute to C. David Allis Open
In 2023, the brilliant chromatin biologist C. David Allis passed away leaving a large void in the scientific community and broken hearts in his family and friends. With this review, we want to tribute Dave's enduring inspiration by focusin…
View article: ZNF512B binds RBBP4 via a variant NuRD interaction motif and aggregates chromatin in a NuRD complex-independent manner
ZNF512B binds RBBP4 via a variant NuRD interaction motif and aggregates chromatin in a NuRD complex-independent manner Open
The evolutionarily conserved histone variant H2A.Z plays a crucial role in various DNA-based processes, but the mechanisms underlying its activity are not completely understood. Recently, we identified the zinc finger (ZF) protein ZNF512B …
View article: ZNF512B binds RBBP4 via a variant NuRD interaction motif and aggregates chromatin in a NuRD complex-independent manner
ZNF512B binds RBBP4 via a variant NuRD interaction motif and aggregates chromatin in a NuRD complex-independent manner Open
The evolutionarily conserved histone variant H2A.Z plays a crucial role in various DNA-based processes but the underlying mechanisms by which it acts are not completely understood. Recently, we identified the zinc finger protein ZNF512B as…
View article: The H2A.Z.1/PWWP2A/NuRD-associated protein HMG20A controls early head and heart developmental transcription programs
The H2A.Z.1/PWWP2A/NuRD-associated protein HMG20A controls early head and heart developmental transcription programs Open
/Summary Specialized chromatin-binding proteins are required for DNA-based processes during development. We recently established PWWP2A as direct histone variant H2A.Z interactor involved in mitosis and cranial-facial development. Here, we…
View article: Organismal Differences in Post-translational Modifications in Histones H3 and H4
Organismal Differences in Post-translational Modifications in Histones H3 and H4 Open
Post-translational modifications (PTMs) of histones play an important role in many cellular processes, notably gene regulation. Using a combination of mass spectrometric and immunobiochemical approaches, we show that the PTM profile of his…
View article: ZAP-70 constitutively regulates gene expression and protein synthesis in chronic lymphocytic leukemia
ZAP-70 constitutively regulates gene expression and protein synthesis in chronic lymphocytic leukemia Open
The expression of ZAP-70 in a subset of chronic lymphocytic leukemia (CLL) patients strongly correlates with a more aggressive clinical course, although the exact underlying mechanisms remain elusive. The ability of ZAP-70 to enhance B-cel…
View article: JAZF1, A Novel p400/TIP60/NuA4 Complex Member, Regulates H2A.Z Acetylation at Regulatory Regions
JAZF1, A Novel p400/TIP60/NuA4 Complex Member, Regulates H2A.Z Acetylation at Regulatory Regions Open
Histone variants differ in amino acid sequence, expression timing and genomic localization sites from canonical histones and convey unique functions to eukaryotic cells. Their tightly controlled spatial and temporal deposition into specifi…
View article: Identification of Histone H3 Lysine 36 Acetylation as a Highly Conserved Histone Modification
Identification of Histone H3 Lysine 36 Acetylation as a Highly Conserved Histone Modification Open
Histone lysine (K) acetylation is a major mechanism by which cells regulate the structure and function of chromatin, and new sites of acetylation continue to be discovered. Here we identify and characterize histone H3K36 acetylation (H3K36…
View article: The Nucleosome Remodeling and Deacetylase complex has an asymmetric, dynamic, and modular architecture
The Nucleosome Remodeling and Deacetylase complex has an asymmetric, dynamic, and modular architecture Open
The Nucleosome Remodeling and Deacetylase (NuRD) complex is essential for development in complex animals but has been refractory to biochemical analysis. We present the first integrated analysis of the architecture of the native mammalian …
View article: Phosphorylation of the ancestral histone variant H3.3 amplifies stimulation-induced transcription
Phosphorylation of the ancestral histone variant H3.3 amplifies stimulation-induced transcription Open
Complex organisms are able to rapidly induce select genes among thousands in response to diverse environmental cues. This occurs in the context of large genomes condensed with histone proteins into chromatin. The macrophage response to pat…
View article: Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression
Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression Open
Inhibitors of DNA topoisomerase I (TOP1), an enzyme relieving torsional stress of DNA by generating transient single-strand breaks, are clinically used to treat ovarian, small cell lung and cervical cancer. As torsional stress is generated…
View article: PWWP2A: A novel mitosis link?
PWWP2A: A novel mitosis link? Open
Substitution of canonical histones by their variant counterparts is an important mean of epigenetic regulation.1 The essential and highly conserved histone variant H2A.Z, member of the H2A variant ...
View article: H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements
H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements Open
Histone chaperones prevent promiscuous histone interactions before chromatin assembly. They guarantee faithful deposition of canonical histones and functionally specialized histone variants into chromatin in a spatial- and temporally-restr…