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View article: NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress
NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress Open
WNK family kinases are regulated by osmotic stress and control ion homeostasis by activating SPAK and OXSR1 kinases. Using a proximity labeling approach, we found that osmotic stress promotes the association of WNK1 with the NRBP1 pseudoki…
View article: Threonine and tyrosine kinase (<scp>TTK</scp>) <scp>mRNA</scp> and protein expression in breast cancer; prognostic significance in the neoadjuvant setting
Threonine and tyrosine kinase (<span>TTK</span>) <span>mRNA</span> and protein expression in breast cancer; prognostic significance in the neoadjuvant setting Open
Aims Threonine and tyrosine kinase (TTK) is up‐regulated in triple‐negative breast cancer (TNBC), yet its expression in patients undergoing neoadjuvant chemotherapy (NACT) remains unexplored. This investigation aims to assess TTK protein e…
View article: NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress
NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress Open
WNK family kinases are regulated by osmotic stress and control ion homeostasis by activating SPAK and OXSR1 kinases. Using a proximity ligation approach, we found that osmotic stress promotes the association of WNK1 with the NRBP1 pseudoki…
View article: Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition
Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition Open
Kinases are important therapeutic targets, and their inhibitors are classified according to their mechanism of action, which range from blocking ATP binding to covalent inhibition. Here, a mechanism of inhibition is highlighted by capturin…
View article: <i>Racgap1</i> knockdown results in cells with multiple cilia due to cytokinesis failure
<i>Racgap1</i> knockdown results in cells with multiple cilia due to cytokinesis failure Open
Most mammalian cells have a single primary cilium that acts as a signalling hub in mediating cellular functions. However, little is known about the mechanisms that result in aberrant supernumerary primary cilia per cell. In this study, we …
View article: Fig S1-4; Table S1, S2, S4 and S5; S methods from Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer
Fig S1-4; Table S1, S2, S4 and S5; S methods from Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer Open
Supplementary information concerning: laser capture microscopy (Fig S1), efficiency of siRNA knock-down (Fig S2), results of siRNA knock-down for ABC gene expression and function (Fig S3), abilities of MUC17 and PCNX1 expression to define …
View article: Data from Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer
Data from Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer Open
Poor-prognosis breast cancers are treated with cytotoxic chemotherapy, but often without any guidance from therapy predictive markers because universally accepted markers are not currently available. Treatment failure, in the form of recur…
View article: Data from Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer
Data from Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer Open
Poor-prognosis breast cancers are treated with cytotoxic chemotherapy, but often without any guidance from therapy predictive markers because universally accepted markers are not currently available. Treatment failure, in the form of recur…
View article: Table S3 from Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer
Table S3 from Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer Open
Somatic variants data
View article: Fig S1-4; Table S1, S2, S4 and S5; S methods from Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer
Fig S1-4; Table S1, S2, S4 and S5; S methods from Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer Open
Supplementary information concerning: laser capture microscopy (Fig S1), efficiency of siRNA knock-down (Fig S2), results of siRNA knock-down for ABC gene expression and function (Fig S3), abilities of MUC17 and PCNX1 expression to define …
View article: Table S3 from Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer
Table S3 from Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer Open
Somatic variants data
View article: The emerging role of MCPH1/BRIT1 in carcinogenesis
The emerging role of MCPH1/BRIT1 in carcinogenesis Open
The MCPH1 gene, also known as BRCT-repeat inhibitor of hTERT expression (BRIT1), has three BRCA1 carboxyl-terminal domains which is an important regulator of DNA repair, cell cycle checkpoints and chromosome condensation. MCPH1/BRIT1 is al…
View article: The Diverse Role of CUB and Sushi Multiple Domains 1 (CSMD1) in Human Diseases
The Diverse Role of CUB and Sushi Multiple Domains 1 (CSMD1) in Human Diseases Open
CUB and Sushi Multiple Domains 1 (CSMD1), a tumour suppressor gene, encodes a large membrane-bound protein including a single transmembrane domain. This transmembrane region has a potential tyrosine phosphorylation site, suggesting that CS…
View article: List of Contributors
List of Contributors Open
conducted extensive ethnobotanical and ethno ecological fieldwork among the indigenous Ese Eja in the border areas of Amazonian Peru and Bolivia on a broad number of issues relating to human-environment relations.His current research focus…
View article: 1031. RADERMACHERA SINICA: Bignoniaceae
1031. RADERMACHERA SINICA: Bignoniaceae Open
Summary Radermachera sinica (Hance) Hemsl., is illustrated. Its history is described, and its survival and flowering in cultivation in London are recorded.
View article: The Role of Csmd1 during Mammary Gland Development
The Role of Csmd1 during Mammary Gland Development Open
The Cub Sushi Multiple Domains-1 (CSMD1) protein is a tumour suppressor which has been shown to play a role in regulating human mammary duct development in vitro. CSMD1 knockdown in vitro demonstrated increased cell proliferation, invasion…
View article: Health Impacts of Construction: An Emerging Research Agenda
Health Impacts of Construction: An Emerging Research Agenda Open
Construction is a vital economic sector to the UK economy that has significant impacts on the local communities it operates within. Best practice and regulation of the construction sector to minimise negative health impacts on local commun…
View article: Interpreting People’s Behavior Toward Primates Using Qualitative Data: a Case Study from North Morocco
Interpreting People’s Behavior Toward Primates Using Qualitative Data: a Case Study from North Morocco Open
People’s perceptions of primates vary across and within cultures and may not be consistent with their behavior toward the primates themselves. We used qualitative data from semistructured and unstructured interviews with shepherds from 10 …
View article: Communicating for conservation: circumventing conflict with communities over domestic dog ownership in north Morocco
Communicating for conservation: circumventing conflict with communities over domestic dog ownership in north Morocco Open
Conservationists consider open and direct communication as best practice even when their data conflict with local beliefs. However, ensuring the effective delivery of a controversial message without overtly challenging community identity i…
View article: Assessing and addressing energy vulnerability at the community scale: an interpretive case study
Assessing and addressing energy vulnerability at the community scale: an interpretive case study Open
The paper adopts a whole systems framework to identify and track efforts by local government and community organisations to address issues of energy vulnerability among residents in an urban borough. When viewed through the lens of energy …
View article: Understanding Human-Animal Relations in the Context of Primate Conservation: A Multispecies Ethnographic Approach in North Morocco
Understanding Human-Animal Relations in the Context of Primate Conservation: A Multispecies Ethnographic Approach in North Morocco Open
Strategies for conserving species threatened with extinction are often driven by ecological data. However, in anthropogenic landscapes, understanding and incorporating local people's perceptions may enhance species conservation. We examine…