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View article: Global and single-nucleotide resolution detection of 7-methylguanosine in RNA
Global and single-nucleotide resolution detection of 7-methylguanosine in RNA Open
RNA modifications, including N-7-methylguanosine (m7G), are pivotal in governing RNA stability and gene expression regulation. The accurate detection of internal m7G modifications is of paramount significance, given recent associations bet…
View article: The impact of tRNA modifications on translation in cancer: identifying novel therapeutic avenues
The impact of tRNA modifications on translation in cancer: identifying novel therapeutic avenues Open
Recent advancements have illuminated the critical role of RNA modifications in post-transcriptional regulation, shaping the landscape of gene expression. This review explores how tRNA modifications emerge as critical players, fine-tuning f…
View article: Additional file 11 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
Additional file 11 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer Open
Additional file 11: Supplementary Table S2. METTL1 bound RNAs in PC3 cells.
View article: Additional file 14 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
Additional file 14 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer Open
Additional file 14: Supplementary Table S5. Differentially synthesised nascent peptides in WT and METTL1 KO PC3 cells.
View article: Additional file 16 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
Additional file 16 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer Open
Additional file 16: Supplementary Table S7. Differentially expressed mRNAs in WT vs METTL1 KO PC3 cells.
View article: Additional file 10 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
Additional file 10 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer Open
Additional file 10: Supplementary Table S1. Differential expression of RNA modifying proteins in human Pca.
View article: Additional file 15 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
Additional file 15 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer Open
Additional file 15: Supplementary Table S6. Differentially expressed proteins in WT and METTL1 KO PC3 cells.
View article: Additional file 12 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
Additional file 12 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer Open
Additional file 12: Supplementary Table S3. METTL1 bound RNAs in HEK293T cells.
View article: Additional file 17 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
Additional file 17 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer Open
Additional file 17: Supplementary Table S8. Correlation of differentially expressed mRNAs and newly synthesized proteins in WT and METTL1 KO PC3 cells.
View article: Additional file 13 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
Additional file 13 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer Open
Additional file 13: Supplementary Table S4. tRNA fragment reads in Control (wt) and METTL1 KO cells.
View article: Epigenetic and Epitranscriptomic Control in Prostate Cancer
Epigenetic and Epitranscriptomic Control in Prostate Cancer Open
The initiation of prostate cancer has been long associated with DNA copy-number alterations, the loss of specific chromosomal regions and gene fusions, and driver mutations, especially those of the Androgen Receptor. Non-mutational events,…
View article: Glia Crosstalk in Neuroinflammatory Diseases
Glia Crosstalk in Neuroinflammatory Diseases Open
Neuroinflammation constitutes a fundamental cellular process to signal the loss of brain homeostasis. Glial cells play a central role in orchestrating these neuroinflammation processes in both deleterious and beneficial ways. These cellula…
View article: Emerging roles of novel small non-coding regulatory RNAs in immunity and cancer
Emerging roles of novel small non-coding regulatory RNAs in immunity and cancer Open
The term small non-coding RNAs (ncRNAs) refers to all those RNAs that even without encoding for a protein, can play important functional roles. Transfer RNA and ribosomal RNA-derived fragments (tRFs and rRFs, respectively) are an emerging …
View article: Cytosine-5 RNA methylation links protein synthesis to cell metabolism
Cytosine-5 RNA methylation links protein synthesis to cell metabolism Open
Posttranscriptional modifications in transfer RNA (tRNA) are often critical for normal development because they adapt protein synthesis rates to a dynamically changing microenvironment. However, the precise cellular mechanisms linking the …
View article: Considerations for skin carcinogenesis experiments using inducible transgenic mouse models
Considerations for skin carcinogenesis experiments using inducible transgenic mouse models Open
OBJECTIVE: This study was designed to estimate the percentage of non-malignant skin tumours (papillomas) progressing to malignant squamous cell carcinomas (SCCs) in a carcinogenesis study using established transgenic mouse models. In our s…
View article: Post-transcriptional modifications in development and stem cells
Post-transcriptional modifications in development and stem cells Open
Cells adapt to their environment by linking external stimuli to an intricate network of transcriptional, post-transcriptional and translational processes. Among these, mechanisms that couple environmental cues to the regulation of protein …
View article: Posttranscriptional methylation of transfer and ribosomal RNA in stress response pathways, cell differentiation, and cancer
Posttranscriptional methylation of transfer and ribosomal RNA in stress response pathways, cell differentiation, and cancer Open
Posttranscriptional modifications such as cytosine-5 methylation are dynamically regulated and may influence tumour development, maintenance, and progression.