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View article: Transcriptomic Landscape of Paclitaxel-Induced Multidrug Resistance in 3D Cultures of Colon Cancer Cell Line DLD1
Transcriptomic Landscape of Paclitaxel-Induced Multidrug Resistance in 3D Cultures of Colon Cancer Cell Line DLD1 Open
Multidrug resistance (MDR) significantly contributes to colon cancer recurrence, making it essential to understand its molecular basis for improved therapies. This study aimed to identify genes and pathways involved in resistance to standa…
View article: Transcript PHF19-207 May Be a Long Non-Coding RNA with Tumor-Promoting Role in Colon Cancer
Transcript PHF19-207 May Be a Long Non-Coding RNA with Tumor-Promoting Role in Colon Cancer Open
Recent pan-cancer transcriptome analysis has revealed differential activity of two alternative PHF19 gene promoters in malignant versus non-malignant gut mucosa. One of these promoters upregulated in colon cancer leads to the expression of…
View article: Transcript PHF19-207 as a Potential Biomarker for Colon Cancer Diagnosis and Screening
Transcript PHF19-207 as a Potential Biomarker for Colon Cancer Diagnosis and Screening Open
A recent comprehensive pan-cancer study indicated the high translational potential of the transcript PHF19-207 as a biomarker for colon cancer. This study aimed to analyze the expression of PHF19-207 in colon tissue samples from two differ…
View article: <scp>AKR1B1</scp> Expression in the Colorectal Tumor Microenvironment Contributes Towards Its Prognostic Significance
<span>AKR1B1</span> Expression in the Colorectal Tumor Microenvironment Contributes Towards Its Prognostic Significance Open
Background AKR1B1, a member of the aldo‐keto reductase enzyme family involved in the polyol pathway of aldehyde metabolism, is aberrantly expressed in colorectal cancer (CRC). Our previous studies demonstrated that AKR1B1 knockdown reduced…
View article: Diagnostic Potential of CD44, CD133, and VDR in Epithelial Ovarian Tumors: Association with Histopathology Parameters
Diagnostic Potential of CD44, CD133, and VDR in Epithelial Ovarian Tumors: Association with Histopathology Parameters Open
Cancer stem cells (CSCs) significantly contribute to heterogeneity, malignancy, and therapy resistance in ovarian cancer. Recent studies emphasize the role of the vitamin D receptor (VDR) in regulating cell differentiation and stemness in …
View article: Cancer 3D Models: Essential Tools for Understanding and Overcoming Drug Resistance
Cancer 3D Models: Essential Tools for Understanding and Overcoming Drug Resistance Open
Anticancer drug resistance remains a major challenge in cancer treatment hindering the efficacy of chemotherapy and targeted therapies. Conventional two-dimensional (2D) cell cultures cannot replicate the complexity of the in vivo t…
View article: Matrix metalloproteinase 9 genotype modulates asthma control in pediatric asthma patients
Matrix metalloproteinase 9 genotype modulates asthma control in pediatric asthma patients Open
Matrix metalloproteinases, particularly MMP9, play a pivotal role in asthma pathology by influencing extracellular matrix remodeling and inflammation. This study examined 100 Serbian pediatric asthma patients to explore the correlation bet…
View article: Altered levels of sphingolipid metabolites in serum of locally advanced rectal cancer patients: A pilot study
Altered levels of sphingolipid metabolites in serum of locally advanced rectal cancer patients: A pilot study Open
Background: Altered sphingolipid levels might contribute to rectal cancer development, progression and therapy response by regulating various biological processes, including apoptosis. This study aimed to analyse the serum sphingolipid pro…
View article: Comparative RNA-Seq Analysis of Colon Spheroids and Patient-derived Tissues Identifies Non-Canonical Transcript Isoforms of Protein-Coding Genes Implicated in Colon Carcinogenesis
Comparative RNA-Seq Analysis of Colon Spheroids and Patient-derived Tissues Identifies Non-Canonical Transcript Isoforms of Protein-Coding Genes Implicated in Colon Carcinogenesis Open
Objectives: This study aimed to identify transcript isoforms of protein-coding genes with potential relevance to the malignant transformation of gut mucosa. Methods: Colon cancer cell lines (HCT116, DLD1, SW620) and immortalized cells deri…
View article: The role of ADAM10 in the prediction of neoadjuvant chemoradiotherapy response in patients with locally advanced rectal cancer
The role of ADAM10 in the prediction of neoadjuvant chemoradiotherapy response in patients with locally advanced rectal cancer Open
Protease ADAM10, a member of the A disintegrin and metalloproteinase protein family, plays a role in cytokine/ growth factor release, the shedding of receptor molecules from the membrane, and intracellular signaling. ADAM10 is implicated i…
View article: Markers of Epithelial–Mesenchymal Transition and Mucinous Histology Are Significant Predictors of Disease Severity and Tumor Characteristics in Early-Onset Colorectal Cancer
Markers of Epithelial–Mesenchymal Transition and Mucinous Histology Are Significant Predictors of Disease Severity and Tumor Characteristics in Early-Onset Colorectal Cancer Open
Approximately 20% of patients with colorectal cancer (CRC) are diagnosed with a mucinous subtype of this tumor, have a worse prognosis, and often show resistance to available therapies. Molecules from the mucin family are involved in the r…
View article: Markers of Epithelial-Mesenchymal Transition and Mucinous Histology in Early-Onset Colorectal Cancer
Markers of Epithelial-Mesenchymal Transition and Mucinous Histology in Early-Onset Colorectal Cancer Open
Approximately 20% of patients with colorectal cancer (CRC) are diagnosed with a mucinous subtype of this tumor, have a worse prognosis, and often show resistance to available therapies. Molecules from the mucin family are involved in the r…
View article: Science on the move - from lab to streets & school (ScienceSCool)
Science on the move - from lab to streets & school (ScienceSCool) Open
“Science on the move - from lab to streets & school” (ScienceSCool) is a two-year project to be
\norganized around the theme "Life in a science bulb (2022)/Life outside the science bulb (2023)"
\nby the Faculty of Physical Ch…
View article: Prognostic relevance of autophagy-related markers p62, LC3, and Beclin1 in ovarian cancer
Prognostic relevance of autophagy-related markers p62, LC3, and Beclin1 in ovarian cancer Open
Prominent p62 and LC3 expression in combination with weak Beclin1 expression in high-grade serous carcinoma indicates potential for the application of autophagy inhibitors in patients with this tumor subtype.
View article: SMAD4–201 transcript as a putative biomarker in colorectal cancer
SMAD4–201 transcript as a putative biomarker in colorectal cancer Open
View article: Inflammatory modulation of the response of bronchial epithelial cells to lipopolysaccharide with pretreatment by montelukast
Inflammatory modulation of the response of bronchial epithelial cells to lipopolysaccharide with pretreatment by montelukast Open
Montelukast, a leukotriene receptor antagonist, is the most prescribed nonsteroidal anti-inflammatory drug used as an add-on therapy for asthma. Besides its effect on blocking leukotriene action, montelukast has been proposed to have secon…
View article: Biomarkers of Uremic Cardiotoxicity
Biomarkers of Uremic Cardiotoxicity Open
Cardiovascular (CV) morbidity and mortality increase along with the progression of chronic kidney disease (CKD). The potential novel biomarkers of cardiotoxicity have been tested with the aim of the early detection of patients at high CV r…
View article: Bacterial Nanocellulose as a Scaffold for In Vitro Cell Migration Assay
Bacterial Nanocellulose as a Scaffold for In Vitro Cell Migration Assay Open
Bacterial nanocellulose (BNC) stands out among polymers as a promising biomaterial due to its mechanical strength, hydrophilicity, biocompatibility, biodegradability, low toxicity and renewability. The use of scaffolds based on BNC for 3D …
View article: Inflammatory Modulation of Bronchial Epithelial Cells’ Response to Lipopolysaccharide with Pretreatment by Montelukast
Inflammatory Modulation of Bronchial Epithelial Cells’ Response to Lipopolysaccharide with Pretreatment by Montelukast Open
Purpose Montelukast, a leukotriene receptor antagonist, is the most prescribed non-steroidal anti-inflammatory drug used as add-on therapy at later stages of asthma to prevent disease progression. Besides its direct anti-inflammatory effec…
View article: FP177Is miR-133a marker of progressive chronic kidney disease?
FP177Is miR-133a marker of progressive chronic kidney disease? Open
Chronic kidney disease (CKD) is associated with a high incidence of cardiovascular (CV) disease and numerous risk factor have been implicated to play a role. Recent studies have shown that the levels of various microRNAs in the serum of pa…
View article: Evaluation of toxicity and antioxidative effects of Tussilago farfara and Verbascum thapsus water extracts in zebrafish and in bronchial epithelial cells
Evaluation of toxicity and antioxidative effects of Tussilago farfara and Verbascum thapsus water extracts in zebrafish and in bronchial epithelial cells Open
Tussilago farfara (coltsfoot) and Verbascum thapsus (mullein) have been used as folk remedies for treating respiratory disorders. The aim of this study was to test the toxicity of the water extracts of T. farfara and V. thapsus in vivo in …
View article: <i>ADRB2</i> gene polymorphisms and salbutamol responsiveness in Serbian children with asthma
<i>ADRB2</i> gene polymorphisms and salbutamol responsiveness in Serbian children with asthma Open
Inhaled β2 adrenergic receptor (β2-AR) agonists are the mainstay of asthma therapy. The β2-AR protein is encoded by the ADRB2 gene and variants within this gene can have significant consequences for modulating the response to asthma therap…
View article: Analiza promotorskih varijanti gena TGFB1 kao faktora rizika i modulatora odgovora na terapiju astme
Analiza promotorskih varijanti gena TGFB1 kao faktora rizika i modulatora odgovora na terapiju astme Open
Transformišući faktor rasta beta 1 (TGFB1) je važan inflamatorni modulator i profibrotički medijator u astmi. Promene u regulaciji ekspresije TGFB1 bi mogle biti povezane sa patogenezom astme i sa adekvatnim odgovorom na terapiju. Cilj ovo…
View article: TGFB1 Gene Promoter Polymorphisms in Serbian Asthmatics
TGFB1 Gene Promoter Polymorphisms in Serbian Asthmatics Open
The results suggest that polymorphism C-509T may be associated with asthma and disease exacerbations, while G-800A is not significant for the etiology and clinical course of the disease. These findings should be confirmed in a larger study…