Explanipedia

Utilization and Outcomes of Structural Heart Disease Interventions in Patients With Prior Mediastinal Radiation Open

Mahmoud Ismayl, Hasaan Ahmed, Andrew M. Goldsweig, Sandra M. Herrmann, Mackram F. Eleid , et al. · 2025

Complement Inhibition Enables Antivascular Endothelial Growth Factor Receptor Therapy in Renal-Limited Thrombotic Microangiopathy Open

Elena-Bianca Barbir, Abdullah Jalal, Lihong Bu, Harry H. Yoon, Nelson Leung , et al. · 2025

Intraarterial Autologous Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease Open

Lina Alatta, Khaled Mosaad Elhusseiny, Allan B. Dietz, Sandra M. Herrmann, Elizabeth C. Lorenz , et al. · 2025

Reinforcing the role of magnesium in preventing cisplatin-induced nephrotoxicity: real-world evidence and clinical implications Open

Luca Nardelli, Arjunmohan Mohan, Sandra M. Herrmann · 2025

Downregulation of LATS1/2 Drives Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Lesion Formation Open

Sivareddy Kotla, Jonghae Lee, Kyung Ae Ko, Weiqing Chen, Venkata Subrahman K Samanthapudi , et al. · 2025

Background Atherothrombosis, the main event leading to acute coronary syndrome (ACS), is strongly linked to disturbed blood flow (d-flow) regions. Although the involvement of the Hippo pathway and its kinases Large Tumor Suppressor Kinase …

Ten tips for an onco-nephrology clinic Open

Elena-Bianca Barbir, Nelson Leung, Sandra M. Herrmann · 2025

An increasing number of cancer patients are benefiting from long term cancer-directed therapy with an ever-expanding arsenal of novel agents from monoclonal antibodies to small molecules and cellular therapies in addition to the mainstay c…

Outcomes and Predictors of Severity of Immunotherapy-Related Myocarditis Open

Damé Idossa, Sandra M. Herrmann, Kathryn J. Ruddy · 2025

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Comparison of the diagnostic and prognostic value of criteria for immune checkpoint inhibitor related myocarditis Open

Milagros Pereyra, Juan Farina, Isabel G. Scalia, Ahmed K. Mahmoud, Michael C. Roarke , et al. · 2025

The ESC-ICOS guidelines were more restrictive than the Bonaca et al. criteria for the diagnosis of ICIrM but similar in terms of prognostic value.

Update on the Assessment of GFR in Patients with Cancer Open

Verônica T. Costa e Silva, Fei Xiong, Lea Mantz, Meghan E. Sise, Sandra M. Herrmann , et al. · 2025

Accurate assessment of GFR is key in patients with cancer to guide drug eligibility, adjust dosing of systemic therapy, and minimize the risks of undertreatment and systemic toxicity. Several aspects of GFR evaluation in patients with canc…

WCN25-1014 TECLISTAMAB AND NIVOLUMAB: A SYNERGISTIC KIDNEY STORM - A CASE OF ACUTE INTERSTITIAL NEPHRITIS WITH DUAL IMMUNOTHERAPY Open

Arjunmohan Mohan, Elena-Bianca Barbir, Sandra M. Herrmann · 2025

Intracapillary Monoclonal IgM Deposition Concomitant With Cold Agglutinin Disease Open

Silvia Titan, Sandra M. Herrmann, Nelson Leung, Pingchuan Zhang, Stephen M. Ansell · 2024

Monoclonal gammopathy of renal significance (MGRS) comprises a spectrum of kidney manifestations distinguished by its clinical and pathological presentations. This article reports a case of a female on her 60s who was referred to Nephrolog…

Synergistic effect of teclistamab with PD-1 inhibition: a case of acute interstitial nephritis with dual immunotherapy Open

Arjunmohan Mohan, Elena-Bianca Barbir, Loren Herrera Hernandez, Nelson Leung, Sandra M. Herrmann · 2024

We report a case of acute interstitial nephritis (AIN) in a 68-year-old male with squamous cell carcinoma (SCC) and relapsed/refractory multiple myeloma (RRMM) who developed acute kidney injury (AKI) shortly after starting teclistamab for …

Sunitinib induced glomerular thrombotic microangiopathy in a patient with refractory pancreatic neuroendocrine tumour Open

Aisha Khan, Margarita Consing Gangelhoff, Simon Moubarak, Sandra M. Herrmann, Karim Nooruddin , et al. · 2024

F18-FDG PET imaging as a diagnostic tool for immune checkpoint inhibitor–associated acute kidney injury Open

Shruti Gupta, Olivia Green‐Lingren, Sudhir Bhimaniya, Aleksandra A. Krokhmal, Heather A. Jacene , et al. · 2024

The impact of hypoxia preconditioning on mesenchymal stem cells performance in hypertensive kidney disease Open

Gurparneet Kaur Sohi, Naba Farooqui, Arjunmohan Mohan, Kamalnath Sankaran Rajagopalan, Xing Li , et al. · 2024

Background Autologous mesenchymal stem cells (MSCs) have emerged as a therapeutic option for many diseases. Hypertensive kidney disease (HKD) might impair MSCs’ reparative ability by altering the biomolecular properties, but the characteri…

Association of Proton Pump Inhibitor Use and Immune Checkpoint Inhibitor-Mediated Acute Kidney Injury: A Meta-Analysis and a Review of Related Outcomes Open

Arjunmohan Mohan, Pajaree Krisanapan, Supawit Tangpanithandee, Charat Thongprayoon, Swetha Rani Kanduri , et al. · 2024

Introduction: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. However, they pose the risk of immune-related adverse events, including ICI-mediated acute kidney injury (ICI-AKI). Recent studies have i…

Capmatinib-Associated Pseudoacute Kidney Injury in Nonsmall Cell Lung Cancer Open

Letícia Sandoval, Yeshwanter Radhakrishnan, Lisa E. Vaughan, Ashley Potter, Aaron S. Mansfield , et al. · 2023

Management of hypertension in patients with cancer: challenges and considerations Open

Shubhi Pandey, Amar Kalaria, Kenar D. Jhaveri, Sandra M. Herrmann, Agnes S. Kim · 2023

The survival rates of many cancers have significantly improved due to recent advancements in cancer screening and therapeutics. Although better cancer outcomes are encouraging, additional health challenges have surfaced, the utmost of whic…

Renal ischemia alters the transcriptomic and epigenetic profile of inflammatory genes in swine scattered tubular-like cells Open

Sara Kazeminia, Xiang Zhu, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq , et al. · 2023

Background: Scattered tubular-like cells (STCs) are differentiated renal tubular cells that during recovery from ischemic injury dedifferentiate to repair other injured renal cells. Renal artery stenosis (RAS), often associated with chroni…

#4067 HYPOXIC PRECONDITIONING FOR THE IMPROVEMENT OF THE REGENERATIVE CAPACITY OF MESENCHYMAL STEM CELLS AND ITS APPLICATION IN HYPERTENSIVE KIDNEY DISEASE Open

Gurparneet Kaur Sohi, Naba Farooqui, Arjunmohan Mohan, Alfonso Eirin, Lilach O. Lerman , et al. · 2023

Background and Aims Autologous mesenchymal stem/stromal cells (MSCs) have emerged as a therapeutic option for many chronic diseases. Hypertensive kidney disease (HKD) might impair MSCs’ reparative ability by altering important biomolecular…

#4220 NOT JUST AIN? OTHER IMMUNE-CHECKPOINT INHIBITOR LESIONS: A SINGLE INSTITUTION'S EXPERIENCE OVER 12 YEARS Open

Salvatore Mignano, Raad Chowdhury, Mariam P. Alexander, Alessia Buglioni, Sandra M. Herrmann · 2023

Background and Aims Immune-checkpoint inhibitors (ICI) are antineoplastic therapies that unleash the immune-system and have revolutionized cancer outcomes. Though they are a drug class with great potential, their effects are not always lim…

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake Open

Alice Williamson, Dougall M. Norris, Xianyong Yin, K. Alaine Broadaway, Anne H. Moxley , et al. · 2023

Differences in Anthropometric Parameters of Children in Six European Countries Open

Semánová Csilla, Gergő József Szöllösi, István Ilyés, Greet Cardon, Julie Latomme , et al. · 2023

Background: The databases of children’s anthropometric parameters are often outdated, rarely representative and are not always available at an international level. Objectives: To present children’s anthropometric parameters in six European…

Immune checkpoint inhibitors and their interaction with proton pump inhibitors–related interstitial nephritis Open

Jing Miao, Sandra M. Herrmann · 2023

Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy and outcomes, leading to an expanding use in millions of patients worldwide. However, they can cause a spectrum of immune-related adverse events (irAEs). Essentially, a…

Immune Checkpoint Inhibitor–Associated Sarcoidosis Reaction in the Kidney: Case Report Open

Mariam Charkviani, Sandra M. Herrmann · 2023

Established and Emerging Cancer Therapies and Cardiovascular System: Focus on Hypertension—Mechanisms and Mitigation Open

Lloyd Butel-Simoes, Tatt Jhong Haw, Trent Williams, S. Sritharan, P. Gadre , et al. · 2023

Cardiovascular disease and cancer are 2 of the leading causes of death worldwide. Although improvements in outcomes have been noted for both disease entities, the success of cancer therapies has come at the cost of at times very impactful …

Loci for insulin processing and secretion provide insight into type 2 diabetes risk Open

K. Alaine Broadaway, Xianyong Yin, Alice Williamson, Victoria A. Parsons, Emma P Wilson , et al. · 2023

Cancer Therapy–Related Hypertension: A Scientific Statement From the American Heart Association Open

Jordana B. Cohen, Nancy J. Brown, Sherry‐Ann Brown, Susan Dent, Daan C.H. van Dorst , et al. · 2023

Contemporary anticancer drugs have significantly improved cancer survival at the expense of cardiovascular toxicities, including heart disease, thromboembolic disease, and hypertension. One of the most common side effects of these drugs is…

Soluble and cell-based markers of immune checkpoint inhibitor-associated nephritis Open

Meghan E. Sise, Qiyu Wang, Harish Seethapathy, Daiana Moreno, Destiny Harden , et al. · 2023

Background Non-invasive biomarkers of immune checkpoint inhibitor-associated acute tubulointerstitial nephritis (ICI-nephritis) are urgently needed. Because ICIs block immune checkpoint pathways that include cytotoxic T lymphocyte antigen …

Onconephrology 2022: An Update Open

Marco Bonilla, Prakash Gudsoorkar, Rimda Wanchoo, Sandra M. Herrmann, Kenar D. Jhaveri · 2022

Onconephrology is an upcoming and expanding subspecialty that deals with the intersections between hematology/oncology and nephrology. With the paradigm shift in the understanding of cancer immunobiology and mechanisms of oncotherapeutic d…

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