Sandra Holmberg
YOU?
Author Swipe
Disentangling the impact of obesity, diet, host factors, and microbiota on small intestinal antimicrobial peptide expression Open
The small intestinal mucosa has the delicate task of allowing absorption of nutrients and limiting microbial colonization at the mucosal surface through production of antimicrobial peptides and proteins (AMPs). However, while environmental…
View article: A history of repeated antibiotic usage leads to microbiota-dependent mucus defects
A history of repeated antibiotic usage leads to microbiota-dependent mucus defects Open
Recent evidence indicates that repeated antibiotic usage lowers microbial diversity and ultimately changes the gut microbiota community. However, the physiological effects of repeated - but not recent - antibiotic usage on microbiota-media…
View article: A history of repeated antibiotic usage leads to microbiota-dependent mucus defects
A history of repeated antibiotic usage leads to microbiota-dependent mucus defects Open
Recent evidence indicates that repeated antibiotic usage lowers microbial diversity and lastingly changes the gut microbiota community. However, the physiological effects of repeated – but not recent – antibiotic usage on microbiota-mediat…
The gut commensal <i>Blautia</i> maintains colonic mucus function under low fiber consumption through short-chain fatty acid-mediated activation of Ffar2 Open
Beneficial gut bacteria are indispensable for developing colonic mucus and fully establishing its protective function against intestinal microorganisms. Low-fiber diet consumption alters the gut bacterial configuration and disturbs this mi…
Immune Resolution Dilemma: Host Antimicrobial Factor S100A8/A9 Modulates Inflammatory Collateral Tissue Damage During Disseminated Fungal Peritonitis Open
Intra-abdominal infection (peritonitis) is a leading cause of severe disease in surgical intensive care units, as over 70% of patients diagnosed with peritonitis develop septic shock. A critical role of the immune system is to return to ho…
S100A8/A9 modulates inflammatory collateral tissue damage during intraperitoneal origin systemic candidiasis Open
Peritonitis is a leading cause of severe sepsis in surgical intensive care units, as over 70% of patients diagnosed with peritonitis develop septic shock. A critical role of the immune system is to return to homeostasis after combating inf…
Stable Redox-Cycling Nitroxide Tempol Has Antifungal and Immune-Modulatory Properties Open
Invasive mycoses remain underdiagnosed and difficult to treat. Hospitalized individuals with compromised immunity increase in number and constitute the main risk group for severe fungal infections. Current antifungal therapy is hampered by…
Cryptococcus neoformans Induces MCP-1 Release and Delays the Death of Human Mast Cells Open
Cryptococcosis, caused by the basidiomycete Cryptococcus neoformans, is a life-threatening disease affecting approximately one million people per year worldwide. Infection can occur when C. neoformans cells are inhaled by immunocompromised…
Evasion of Immune Surveillance in Low Oxygen Environments Enhances Candida albicans Virulence Open
Successful human colonizers have evolved mechanisms to bypass immune surveillance. Infiltration of PMNs to the site of infection led to the generation of a low oxygen niche. Exposure to low oxygen levels induced fungal cell wall masking, w…