Sandra Howell
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View article: Safety Outcomes of Hybrid Open Chest Transvenous Lead Extraction: A Multicenter Experience
Safety Outcomes of Hybrid Open Chest Transvenous Lead Extraction: A Multicenter Experience Open
Background: Hybrid open chest transvenous lead extraction (TLE), combining surgical and endovascular techniques, may be utilized in patients requiring concomitant cardiac surgery or with high‐risk features for endovascular extraction. Outc…
View article: A review on the impact of cardiac pacing on right ventricular and tricuspid valve function
A review on the impact of cardiac pacing on right ventricular and tricuspid valve function Open
We will provide practical recommendations for the pacing modality of choice in different settings to reduce the risk of TR progression and/or RVD. We will comment on the promising developments in cardiac pacing to reduce the risk of RVD an…
View article: Efficacy of leadless left ventricular endocardial stimulation for non-responders to cardiac resynchronization therapy
Efficacy of leadless left ventricular endocardial stimulation for non-responders to cardiac resynchronization therapy Open
Background Non-responders to conventional coronary sinus CRT represent a high-risk heart failure population with limited treatment options. Leadless LV endocardial pacing may provide benefit by delivering more physiological activation patt…
View article: Comparing the effects of left bundle branch pacing and leadless right ventricular pacing on intraventricular and interventricular dyssynchrony using in silico modelling
Comparing the effects of left bundle branch pacing and leadless right ventricular pacing on intraventricular and interventricular dyssynchrony using in silico modelling Open
Introduction Non-physiological right ventricular pacing (RVP) is currently the mainstay of treatment for patients with high-degree atrioventricular (AV) block who have preserved left ventricular ejection fraction. Newer pacing strategies, …
View article: Joint Pacing and Vascular Intervention for the Management of Cardiac Device Associated Central Venous Obstruction
Joint Pacing and Vascular Intervention for the Management of Cardiac Device Associated Central Venous Obstruction Open
Background and Aims Central venous obstruction (CVO) increases the complexity of pacing interventions, whether it be with device‐associated symptomatic superior vena cava syndrome (SVCS), or by impeding new implants. Endovascular treatment…
View article: Robust Noisy Pseudo-label Learning for Semi-supervised Medical Image Segmentation Using Diffusion Model
Robust Noisy Pseudo-label Learning for Semi-supervised Medical Image Segmentation Using Diffusion Model Open
Obtaining pixel-level annotations in the medical domain is both expensive and time-consuming, often requiring close collaboration between clinical experts and developers. Semi-supervised medical image segmentation aims to leverage limited …
View article: Catheter detection and segmentation in X-ray images via multi-task learning
Catheter detection and segmentation in X-ray images via multi-task learning Open
Purpose Automated detection and segmentation of surgical devices, such as catheters or wires, in X-ray fluoroscopic images have the potential to enhance image guidance in minimally invasive heart surgeries. Methods In this paper, we presen…
View article: Effect of leadless left ventricular endocardial and left bundle branch area pacing on biventricular repolarization metrics
Effect of leadless left ventricular endocardial and left bundle branch area pacing on biventricular repolarization metrics Open
Optimized leadless LV endocardial lateral wall pacing and LBBAP improve ECGi-derived ventricular repolarization metrics. LV-only pacing seemed superior to endocardial BiVP, potentially reflecting repolarization heterogeneity caused by a co…
View article: Catheter Detection and Segmentation in X-ray Images via Multi-task Learning
Catheter Detection and Segmentation in X-ray Images via Multi-task Learning Open
Automated detection and segmentation of surgical devices, such as catheters or wires, in X-ray fluoroscopic images have the potential to enhance image guidance in minimally invasive heart surgeries. In this paper, we present a convolutiona…
View article: Cardiac implantable electronic devices in the setting of tricuspid valve intervention: Risks, options, extraction and future perspectives: A state-of-the-art review
Cardiac implantable electronic devices in the setting of tricuspid valve intervention: Risks, options, extraction and future perspectives: A state-of-the-art review Open
Tricuspid regurgitation is associated with increased risk of heart failure and mortality. To address this, tricuspid valve (TV) interventions in the form of transcatheter and surgical TV procedures have rapidly emerged. TV interventions ar…
View article: In silico pace mapping identifies pacing sites more accurately than inverse body surface potential mapping
In silico pace mapping identifies pacing sites more accurately than inverse body surface potential mapping Open
In silico pace mapping is more accurate than ECGi in detecting paced activation. Performance was optimal when all BSPs were used and reduced during RV apical pacing.
View article: Optimizing outcomes from cardiac resynchronization therapy: what do recent data and insights say?
Optimizing outcomes from cardiac resynchronization therapy: what do recent data and insights say? Open
Ever-expanding research in the field of device therapy has armed physicians with more tools than ever to treat dyssynchronous HF. Newer developments, such as artificial intelligence (AI) guided device programming and conduction system paci…
View article: Left ventricular electrical delay predicts volumetric response to leadless cardiac resynchronization therapy
Left ventricular electrical delay predicts volumetric response to leadless cardiac resynchronization therapy Open
Increased Q-LV was associated with improved reverse remodeling following leadless CRT. Targeting LV endocardial sites of high Q-LV may deliver additional benefit compared to empirical LV electrode implantation.
View article: Convergent ablation for persistent atrial fibrillation: A UK multicentre perspective
Convergent ablation for persistent atrial fibrillation: A UK multicentre perspective Open
Atrial fibrillation (AF) is the most common sustained arrhythmia worldwide and remains a major cause of morbidity and mortality. Unfortunately, a significant proportion of patients have persistent AF, for which conventional catheter ablati…
View article: Optimizing electrical efficacy of leadless cardiac resynchronization therapy and leadless left ventricular septal pacing: Insights on left and right ventricular activation from electrocardiographic imaging
Optimizing electrical efficacy of leadless cardiac resynchronization therapy and leadless left ventricular septal pacing: Insights on left and right ventricular activation from electrocardiographic imaging Open
Leadless CRT significantly improves acute ECGi-derived activation and dyssynchrony metrics. Using an individualized OPM improves efficacy in selected patients. Effective LVSP is feasible, with fusion pacing at LV-OPT mitigating the potenti…
View article: Heart Size Difference Drives Sex‐Specific Response to Cardiac Resynchronization Therapy: A Post Hoc Analysis of the MORE‐MPP CRT Trial
Heart Size Difference Drives Sex‐Specific Response to Cardiac Resynchronization Therapy: A Post Hoc Analysis of the MORE‐MPP CRT Trial Open
Background Studies have reported that female sex predicts superior cardiac resynchronization therapy (CRT) response. One theory is that this association is related to smaller female heart size, thus increased relative dyssynchrony at a giv…
View article: Optimising electrical performance of leadless cardiac resynchronisation therapy and leadless LV septal pacing
Optimising electrical performance of leadless cardiac resynchronisation therapy and leadless LV septal pacing Open
Introduction Leadless left ventricular (LV) endocardial pacing with the WiSE-CRT System is an emerging form of cardiac resynchronisation therapy (CRT). The system was designed to provide lateral wall LV pacing (LVP) via an endocardial rece…
View article: Enhancing transvenous lead extraction risk prediction: Integrating imaging biomarkers into machine learning models
Enhancing transvenous lead extraction risk prediction: Integrating imaging biomarkers into machine learning models Open
Risk prediction tools integrating imaging biomarkers significantly increases the ability of ML models to predict risk of MAE and long procedural time related to TLE.
View article: Heart size disparity drives sex-specific response to cardiac resynchronization therapy: a post-hoc analysis of the MORE-MPP CRT trial
Heart size disparity drives sex-specific response to cardiac resynchronization therapy: a post-hoc analysis of the MORE-MPP CRT trial Open
Background Studies have reported that female sex predicts superior cardiac resynchronization therapy (CRT) response. One theory is that this association is related to smaller female heart size, thus increased “relative dyssynchrony” at giv…
View article: Cost‐effectiveness analysis of leadless cardiac resynchronization therapy
Cost‐effectiveness analysis of leadless cardiac resynchronization therapy Open
Background The Wireless Stimulation Endocardially for CRT (WiSE‐CRT) system is a novel technology used to treat patients with dyssynchronous heart failure (HF) by providing leadless cardiac resynchronization therapy (CRT). Observational st…
View article: Managing arrhythmia in cardiac resynchronisation therapy
Managing arrhythmia in cardiac resynchronisation therapy Open
Arrhythmia is an extremely common finding in patients receiving cardiac resynchronisation therapy (CRT). Despite this, in the majority of randomised trials testing CRT efficacy, patients with a recent history of arrhythmia were excluded. M…
View article: Long-term survival following transvenous lead extraction: unpicking differences according to sex
Long-term survival following transvenous lead extraction: unpicking differences according to sex Open
Aims Female sex is a recognized risk factor for procedure-related major complications including in-hospital mortality following transvenous lead extraction (TLE). Long-term outcomes following TLE stratified by sex are unclear. The purpose …