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View article: The Role of Type I Interferons in Tuberculosis and in Tuberculosis-Risk-Associated Comorbidities
The Role of Type I Interferons in Tuberculosis and in Tuberculosis-Risk-Associated Comorbidities Open
The identification of a type I interferon-induced transcriptomic signature in active tuberculosis suggests a potential role for these interferons in the pathogenesis of tuberculosis. Comorbidities such as human immunodeficiency virus, diab…
View article: Improved antibody breadth with an extended primary dose interval of COVID-19 vaccine is overcome by boosters
Improved antibody breadth with an extended primary dose interval of COVID-19 vaccine is overcome by boosters Open
Introduction During rollout of mRNA-based COVID-19 vaccines, several jurisdictions extended the interval between the first and second doses to prioritize wider population access to limited vaccine supply. This study evaluated the effects o…
View article: Sex-specific immune responses to COVID-19 vaccination in end-stage renal disease patients
Sex-specific immune responses to COVID-19 vaccination in end-stage renal disease patients Open
Background End-stage renal disease (ESRD) patients have muted memory B cell formation and reduced humoral responses to COVID-19 vaccination; however, early innate immune responses have yet to be characterized. Sex-stratification is also li…
View article: Type I interferons and Mycobacterium tuberculosis whole cell lysate induce distinct transcriptional responses in M. tuberculosis infection
Type I interferons and Mycobacterium tuberculosis whole cell lysate induce distinct transcriptional responses in M. tuberculosis infection Open
Type I interferon (IFN)-induced genes have the potential for distinguishing active tuberculosis (ATB) from latent TB infection (LTBI) and healthy controls (HC), monitoring treatment, and detection of individuals at risk of progression to a…
View article: Evaluation of a collaborative model for successful implementation of a National CD4 enumeration EQA program in Cameroon
Evaluation of a collaborative model for successful implementation of a National CD4 enumeration EQA program in Cameroon Open
Participation in an EQA program is critical to the quality assurance process. Reliable and precise CD4 T-cells enumeration are essential to improve the clinical management of patients by evaluating the disease progression and by monitoring…
View article: Expansion of tissue-resident CD8+ T cells and CD4+ Th17 cells in the nasal mucosa following mRNA COVID-19 vaccination
Expansion of tissue-resident CD8+ T cells and CD4+ Th17 cells in the nasal mucosa following mRNA COVID-19 vaccination Open
Vaccines against SARS-CoV-2 have shown high efficacy in clinical trials, yet a full immunologic characterization of these vaccines, particularly within the upper respiratory tract, remains lacking. We enumerated and phenotyped T cells in n…
View article: Serological and cellular inflammatory signatures in end‐stage kidney disease and latent tuberculosis
Serological and cellular inflammatory signatures in end‐stage kidney disease and latent tuberculosis Open
Objectives Tuberculosis comorbidity with chronic diseases including diabetes, HIV and chronic kidney disease is of rising concern. In particular, latent tuberculosis infection (LTBI) comorbidity with end‐stage kidney disease (ESKD) is asso…
View article: Recommendations for sample pooling on the Cepheid GeneXpert® system using the Cepheid Xpert® Xpress SARS-CoV-2 assay
Recommendations for sample pooling on the Cepheid GeneXpert® system using the Cepheid Xpert® Xpress SARS-CoV-2 assay Open
The coronavirus disease 2019 (Covid-19) pandemic, caused by SARS-CoV-2, has resulted in a global testing supply shortage. In response, pooled testing has emerged as a promising strategy that can immediately increase testing capacity. In po…
View article: Recommendations for sample pooling on the Cepheid GeneXpert<sup>®</sup>system using the Cepheid Xpert<sup>®</sup>Xpress SARS-CoV-2 assay
Recommendations for sample pooling on the Cepheid GeneXpert<sup>®</sup>system using the Cepheid Xpert<sup>®</sup>Xpress SARS-CoV-2 assay Open
The coronavirus disease 2019 (Covid-19) pandemic, caused by SARS-CoV-2, has resulted in a global testing supply shortage. In response, pooled testing has emerged as a promising strategy that can immediately increase testing capacity. Here,…
View article: Mucosal-Associated Invariant T Cells Are Depleted and Exhibit Altered Chemokine Receptor Expression and Elevated Granulocyte Macrophage-Colony Stimulating Factor Production During End-Stage Renal Disease
Mucosal-Associated Invariant T Cells Are Depleted and Exhibit Altered Chemokine Receptor Expression and Elevated Granulocyte Macrophage-Colony Stimulating Factor Production During End-Stage Renal Disease Open
The loss of peripheral blood MAIT cells and associated shifts in tissue homing receptor expression and GM-CSF production may contribute to an immune environment that is permissive to bacterial replication, particularly in the lungs.
View article: Latent tuberculosis infection: An overview
Latent tuberculosis infection: An overview Open
Latent tuberculosis infection (LTBI) is defined as a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens without evidence of clinically manifested active tuberculosis (TB) disease. Individuals with LTB…