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View article: Covalent Probes Reveal Small-Molecule Binding Pockets in Structured RNA and Enable Bioactive Compound Design
Covalent Probes Reveal Small-Molecule Binding Pockets in Structured RNA and Enable Bioactive Compound Design Open
The SARS-CoV-2 frameshift stimulation element (FSE) is a critical RNA structure that is essential for viral replication and represents a promising target for antiviral intervention. Here, Chemical Cross-Linking and Isolation by Pull-down (…
View article: Inhibition of PTCH1 drug efflux activity enhances chemotherapy efficacy against triple negative breast cancer
Inhibition of PTCH1 drug efflux activity enhances chemotherapy efficacy against triple negative breast cancer Open
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subgroup characterized by a high risk of resistance to chemotherapies and high relapse potential. High levels of mRNA from the Hedgehog receptor PTCH1 are associated…
View article: Transcriptome-Wide, Unbiased Profiling of Ribonuclease Targeting Chimeras
Transcriptome-Wide, Unbiased Profiling of Ribonuclease Targeting Chimeras Open
Various approaches have been developed to target RNA and modulate its function with modes of action including binding and cleavage. Herein, we explored how small molecule binding is correlated with cleavage induced by heterobifunctional ri…
View article: Identification of small molecules affecting the interaction between human hemoglobin and Staphylococcus aureus IsdB hemophore
Identification of small molecules affecting the interaction between human hemoglobin and Staphylococcus aureus IsdB hemophore Open
Human hemoglobin (Hb) is the preferred iron source of Staphylococcus aureus . This pathogenic bacterium exploits a sophisticated protein machinery called Iron-regulated surface determinant (Isd) system to bind Hb, extract and internalize h…
View article: Chasing new targets to fight antimicrobial resistance: identification of small molecules affecting the interaction of human hemoglobin with the IsdB hemophore of Staphylococcus aureus
Chasing new targets to fight antimicrobial resistance: identification of small molecules affecting the interaction of human hemoglobin with the IsdB hemophore of Staphylococcus aureus Open
Human hemoglobin (Hb) is the preferred iron source of Staphylococcus aureus. This pathogenic bacterium exploits a sophisticated protein machinery called Iron-regulated surface determinant (Isd) system to bind Hb, extract and internalize he…
View article: A community effort in SARS‐CoV‐2 drug discovery
A community effort in SARS‐CoV‐2 drug discovery Open
The COVID‐19 pandemic continues to pose a substantial threat to human lives and is likely to do so for years to come. Despite the availability of vaccines, searching for efficient small‐molecule drugs that are widely available, including i…
View article: A community effort to discover small molecule SARS-CoV-2 inhibitors
A community effort to discover small molecule SARS-CoV-2 inhibitors Open
The COVID-19 pandemic continues to pose a substantial threat to human lives and is likely to do so for years to come. Despite the availability of vaccines, searching for efficient small-molecule drugs that are widely available, including i…
View article: Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein
Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein Open
BRAF is a serine/threonine kinase frequently mutated in human cancers. BRAFV600E mutated protein is targeted through the use of kinase inhibitors which are approved for the treatment of melanoma; however, their long-term efficacy is hamper…
View article: Molecular insights into the Patched1 drug efflux inhibitory activity of panicein A hydroquinone: a computational study
Molecular insights into the Patched1 drug efflux inhibitory activity of panicein A hydroquinone: a computational study Open
Human Hedgehog receptor Patched1 is able to efflux chemotherapeutics of different chemical structure out of cancer cells thus contributing to multidrug resistance phenomena in tumor treatment.
View article: JEDI Billion Molecules against Covid-19: compounds synthesized
JEDI Billion Molecules against Covid-19: compounds synthesized Open
On May 4th 2020 a GrandChallenge entitled "Billion molecules against Covid-19" was launched by the Joint European Disruptive Initiative (JEDI). Teams from all over the world provided lists of compounds with suspected inhibitory properties …
View article: JEDI Billion Molecules against Covid-19: compounds synthesized
JEDI Billion Molecules against Covid-19: compounds synthesized Open
On May 4th 2020 a GrandChallenge entitled "Billion molecules against Covid-19" was launched by the Joint European Disruptive Initiative (JEDI). Teams from all over the world provided lists of compounds with suspected inhibitory properties …
View article: JEDI Billion Molecules against Covid-19: compounds synthesized
JEDI Billion Molecules against Covid-19: compounds synthesized Open
On May 4th 2020 a GrandChallenge entitled "Billion molecules against Covid-19" was launched by the Joint European Disruptive Initiative (JEDI). Teams from all over the world provided lists of compounds with suspected inhibitory properties …
View article: Iron Metabolism at the Interface between Host and Pathogen: From Nutritional Immunity to Antibacterial Development
Iron Metabolism at the Interface between Host and Pathogen: From Nutritional Immunity to Antibacterial Development Open
Nutritional immunity is a form of innate immunity widespread in both vertebrates and invertebrates. The term refers to a rich repertoire of mechanisms set up by the host to inhibit bacterial proliferation by sequestering trace minerals (ma…