Sandra L. Taylor
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View article: Metabolomic assessment of low versus high volume resuscitation in a combined porcine model of severe burn and traumatic brain injury
Metabolomic assessment of low versus high volume resuscitation in a combined porcine model of severe burn and traumatic brain injury Open
Background: Severe burns continue to be associated with significant morbidity and mortality despite advances in resuscitation techniques. Concomitant injury such as traumatic brain injury adds complexity to resuscitation paradigms as high …
View article: A longitudinal evaluation of gastrointestinal symptoms in children with autism spectrum disorder
A longitudinal evaluation of gastrointestinal symptoms in children with autism spectrum disorder Open
Gastrointestinal symptoms are frequently reported in children diagnosed with autism spectrum disorder. This study sought to determine the longitudinal trajectory of gastrointestinal symptoms without a medical etiology in children with auti…
View article: A - 44 Psychological Readiness to Return to Sport Following a Concussion
A - 44 Psychological Readiness to Return to Sport Following a Concussion Open
Purpose To examine varsity athletes’ psychological readiness to return to sport (RTS) following a sport-related concussion (SRC). Method Nine varsity athletes completed a modified ACL-RSI self-report questionnaire at four points of the RTS…
View article: Developing and Applying the BE-FAIR Equity Framework to a Population Health Predictive Model: A Retrospective Observational Cohort Study
Developing and Applying the BE-FAIR Equity Framework to a Population Health Predictive Model: A Retrospective Observational Cohort Study Open
Background Population health programs rely on healthcare predictive models to allocate resources, yet models can perpetuate biases that exacerbate health disparities among marginalized communities. Objective We developed the Bias-reduction…
View article: A non-randomized pilot study to test the feasibility of developing a frailty scale for pet cats
A non-randomized pilot study to test the feasibility of developing a frailty scale for pet cats Open
Introduction Human frailty has long been studied and dozens of “frailty scales” have been developed, but equivalent research is more limited in cats. This pilot study aimed to determine the feasibility of recruiting and retaining veterinar…
View article: Advancing workforce development and scientific collaboration: A novel resource for biostatistical education
Advancing workforce development and scientific collaboration: A novel resource for biostatistical education Open
A clinical and translational scientist (CTS) often seeks to increase their knowledge of statistical topics to effectively conduct biomedical research studies. A common method for obtaining this knowledge is through existing online educatio…
View article: Derivation of a clinical decision rule for termination of resuscitation in non-traumatic pediatric out-of-hospital cardiac arrest
Derivation of a clinical decision rule for termination of resuscitation in non-traumatic pediatric out-of-hospital cardiac arrest Open
We derived a clinical prediction rule with high specificity and positive predictive value in prehospital settings utilizing Advanced Life Support (ALS) providers which may inform termination of resuscitation considerations in pediatric pat…
View article: Pharmacokinetics and sedative effects of single-dose oral gabapentin in cheetahs (Acinonyx jubatus)
Pharmacokinetics and sedative effects of single-dose oral gabapentin in cheetahs (Acinonyx jubatus) Open
OBJECTIVE To assess the pharmacokinetics and sedative effects of a single administration of oral gabapentin in African cheetahs ( Acinonyx jubatus ) at 2 different dosages. METHODS Adult cheetahs (n = 16) located at 3 different zoological …
View article: Methods for building a staff workforce of quantitative scientists in academic health care
Methods for building a staff workforce of quantitative scientists in academic health care Open
Collaborative quantitative scientists, including biostatisticians, epidemiologists, bioinformaticists, and data‐related professionals, play vital roles in research, from study design to data analysis and dissemination. It is imperative tha…
View article: Evaluating acidic gastroesophageal reflux with wireless <scp>pH</scp> monitoring in <scp>French</scp> bulldogs with sliding hiatal herniation
Evaluating acidic gastroesophageal reflux with wireless <span>pH</span> monitoring in <span>French</span> bulldogs with sliding hiatal herniation Open
Background Sliding hiatal herniation (SHH) and gastroesophageal reflux (GER) commonly occur in French bulldogs. Wireless pH monitoring can quantitatively assess acidic GER in dogs affected by SHH. Hypothesis/Objectives Measure acidic GER i…
View article: The SocialVidStim: a video database of positive and negative social evaluation stimuli for use in social cognitive neuroscience paradigms
The SocialVidStim: a video database of positive and negative social evaluation stimuli for use in social cognitive neuroscience paradigms Open
This paper describes the SocialVidStim—a database of video stimuli available to the scientific community depicting positive and negative social evaluative and neutral statements. The SocialVidStim comprises 53 diverse individuals reflectin…
View article: The diagnostic yield of preoperative screening for oral cancer in dogs over 15 years, part 1: locoregional screening
The diagnostic yield of preoperative screening for oral cancer in dogs over 15 years, part 1: locoregional screening Open
OBJECTIVE Determine locoregional diagnostic yield of 4-site screening (head, neck, chest, and abdomen) to diagnose metastatic disease or clinically significant comorbid diseases in dogs with oral cancer. ANIMALS 381 dogs with histologicall…
View article: A Least Absolute Shrinkage and Selection Operator-Derived Predictive Model for Postoperative Respiratory Failure in a Heterogeneous Adult Elective Surgery Patient Population
A Least Absolute Shrinkage and Selection Operator-Derived Predictive Model for Postoperative Respiratory Failure in a Heterogeneous Adult Elective Surgery Patient Population Open
This single-center proof-of-concept study demonstrated that a structured query language extract, transform, and load process, based on readily available patient and intraoperative variables, can be used to develop a prediction model for PR…
View article: The diagnostic yield of preoperative screening for oral cancer in dogs over 15 years, part 2: distant screening
The diagnostic yield of preoperative screening for oral cancer in dogs over 15 years, part 2: distant screening Open
OBJECTIVE Determine diagnostic yield of chest, abdomen, and 4-site screening to diagnose metastatic disease and secondary diseases of prognostic significance in dogs with oral cancer. SAMPLE Medical records from 381 dogs with histologicall…
View article: A Pilot Validation Study Comparing Fluorescence-Imitating Brightfield Imaging, A Slide-Free Imaging Method, With Standard Formalin-Fixed, Paraffin-Embedded Hematoxylin-Eosin–Stained Tissue Section Histology for Primary Surgical Pathology Diagnosis
A Pilot Validation Study Comparing Fluorescence-Imitating Brightfield Imaging, A Slide-Free Imaging Method, With Standard Formalin-Fixed, Paraffin-Embedded Hematoxylin-Eosin–Stained Tissue Section Histology for Primary Surgical Pathology Diagnosis Open
Context.— Digital pathology using whole slide images has been recently approved to support primary diagnosis in clinical surgical pathology practices. Here we describe a novel imaging method, fluorescence-imitating brightfield imaging, tha…
View article: Examining indicators of psychosocial risk and resilience in parents of autistic children
Examining indicators of psychosocial risk and resilience in parents of autistic children Open
Background Parents of autistic children experience increased levels of caregiver strain and adverse mental health outcomes, even in comparison to parents of children with other neurodevelopmental disabilities. Previous studies have largely…
View article: <scp>HipScreen</scp> mobile app for the measurement of hip migration percentage in children with cerebral palsy: Accuracy, reliability, and discriminatory ability
<span>HipScreen</span> mobile app for the measurement of hip migration percentage in children with cerebral palsy: Accuracy, reliability, and discriminatory ability Open
Aim To assess the accuracy, reliability, and discriminatory ability of a mobile app for measurement of migration percentage in hip surveillance radiographs of children with cerebral palsy (CP). Method The free mobile app HipScreen ( www.hi…
View article: 88 Does Weight Matter? A Secondary Analysis from ABRUPT
88 Does Weight Matter? A Secondary Analysis from ABRUPT Open
Introduction Burn shock resuscitation fluids should be titrated to achieve a urine output (UOP) of 0.5 to 1 mL/kg/hr. It is unknown whether this UOP goal should be indexed to actual body weight (ABW) or predicted body weight (PBW). The pur…
View article: Data from Metabolomic Markers of Altered Nucleotide Metabolism in Early Stage Adenocarcinoma
Data from Metabolomic Markers of Altered Nucleotide Metabolism in Early Stage Adenocarcinoma Open
Adenocarcinoma, a type of non–small cell lung cancer, is the most frequently diagnosed lung cancer and the leading cause of lung cancer mortality in the United States. It is well documented that biochemical changes occur early in the trans…
View article: Figure S1 from Metabolomic Markers of Altered Nucleotide Metabolism in Early Stage Adenocarcinoma
Figure S1 from Metabolomic Markers of Altered Nucleotide Metabolism in Early Stage Adenocarcinoma Open
Figure S1. Partial correlation and mass spectral similarity network between structurally identified and structurally unknown O-PLS-DA selected discriminants for adenocarcinoma (Table 2 and Table S2).
View article: Figure S2 from Metabolomic Markers of Altered Nucleotide Metabolism in Early Stage Adenocarcinoma
Figure S2 from Metabolomic Markers of Altered Nucleotide Metabolism in Early Stage Adenocarcinoma Open
Figure S2. Boxplots for each metabolite comparing the relative intensities of the quantified ion in tumor and control tissues.
View article: Data from Metabolomic Markers of Altered Nucleotide Metabolism in Early Stage Adenocarcinoma
Data from Metabolomic Markers of Altered Nucleotide Metabolism in Early Stage Adenocarcinoma Open
Adenocarcinoma, a type of non–small cell lung cancer, is the most frequently diagnosed lung cancer and the leading cause of lung cancer mortality in the United States. It is well documented that biochemical changes occur early in the trans…