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View article: Chloramphenicol-mobilized <i>Bacillus subtilis</i> elevates transient expression of multiple antibiotic resistance genes, including the glycopeptides phleomycin and bleomycin
Chloramphenicol-mobilized <i>Bacillus subtilis</i> elevates transient expression of multiple antibiotic resistance genes, including the glycopeptides phleomycin and bleomycin Open
Antibiotic resistance is a global crisis that stems from the use of antibiotics as an essential part of modern medicine. Understanding how antibiotic resistance is controlled among cells in bacterial populations will provide insights into …
View article: Reviewer #2 (Public Review): MOB rules: Antibiotic Exposure Reprograms Metabolism to Mobilize Bacillus subtilis in Competitive Interactions
Reviewer #2 (Public Review): MOB rules: Antibiotic Exposure Reprograms Metabolism to Mobilize Bacillus subtilis in Competitive Interactions Open
Antibiotics have dose-dependent effects on exposed bacteria. The medicinal use of antibiotics relies on their growth-inhibitory activities at sufficient concentrations. At subinhibitory concentrations, exposure effects vary widely among di…
View article: MOB rules: Antibiotic Exposure Reprograms Metabolism to Mobilize Bacillus subtilis in Competitive Interactions
MOB rules: Antibiotic Exposure Reprograms Metabolism to Mobilize Bacillus subtilis in Competitive Interactions Open
Antibiotics have dose-dependent effects on exposed bacteria. The medicinal use of antibiotics relies on their growth-inhibitory activities at sufficient concentrations. At subinhibitory concentrations, exposure effects vary widely among di…
View article: MOB rules: Antibiotic Exposure Reprograms Metabolism to Mobilize Bacillus subtilis in Competitive Interactions
MOB rules: Antibiotic Exposure Reprograms Metabolism to Mobilize Bacillus subtilis in Competitive Interactions Open
Antibiotics have dose-dependent effects on exposed bacteria. The medicinal use of antibiotics relies on their growth-inhibitory activities at sufficient concentrations. At subinhibitory concentrations, exposure effects vary widely among di…
View article: MOB rules: Antibiotic Exposure Reprograms Metabolism to Mobilize <i>Bacillus subtilis</i> in Competitive Interactions
MOB rules: Antibiotic Exposure Reprograms Metabolism to Mobilize <i>Bacillus subtilis</i> in Competitive Interactions Open
Antibiotics have dose-dependent effects on exposed bacteria. The medicinal use of antibiotics relies on their growth-inhibitory activities at sufficient concentrations. At subinhibitory concentrations, exposure effects vary widely among di…
View article: <i>mucG, mucH,</i> and <i>mucI</i> Modulate Production of Mutanocyclin and Reutericyclins in Streptococcus mutans B04Sm5
<i>mucG, mucH,</i> and <i>mucI</i> Modulate Production of Mutanocyclin and Reutericyclins in Streptococcus mutans B04Sm5 Open
S. mutans must be able to outcompete neighboring organisms in its ecological niche in order to cause dental caries. S. mutans B04Sm5 inhibited the growth of neighboring commensal streptococci through production of reutericyclins via the mu…
View article: <i>mucG, mucH</i>, and <i>mucI</i> modulate production of mutanocyclin and reutericyclins in <i>Streptococcus mutans</i> B04Sm5
<i>mucG, mucH</i>, and <i>mucI</i> modulate production of mutanocyclin and reutericyclins in <i>Streptococcus mutans</i> B04Sm5 Open
Streptococcus mutans is considered a primary etiologic agent of dental caries, which is the most common chronic infectious disease worldwide. S. mutans B04Sm5 was recently shown to produce reutericyclins and mutanocyclin through the muc bi…
View article: Crowdsourcing biocuration: The Community Assessment of Community Annotation with Ontologies (CACAO)
Crowdsourcing biocuration: The Community Assessment of Community Annotation with Ontologies (CACAO) Open
Experimental data about gene functions curated from the primary literature have enormous value for research scientists in understanding biology. Using the Gene Ontology (GO), manual curation by experts has provided an important resource fo…
View article: Crowdsourcing biocuration: the Community Assessment of Community Annotation with Ontologies (CACAO)
Crowdsourcing biocuration: the Community Assessment of Community Annotation with Ontologies (CACAO) Open
Experimental data about known gene functions curated from the primary literature have enormous value for research scientists in understanding biology. Using the Gene Ontology (GO), manual curation by experts has provided an important resou…
View article: The Gene Ontology resource: enriching a GOld mine
The Gene Ontology resource: enriching a GOld mine Open
The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two y…
View article: Cariogenic <i>Streptococcus mutans</i> Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization
Cariogenic <i>Streptococcus mutans</i> Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization Open
Streptococcus mutans is a common constituent of dental plaque and a major etiologic agent of dental caries (tooth decay). In this study, we elucidated the biosynthetic pathway encoded by muc, a hybrid polyketide synthase and nonribosomal p…
View article: Cariogenic<i>Streptococcus mutans</i>produces strain-specific antibiotics that impair commensal colonization
Cariogenic<i>Streptococcus mutans</i>produces strain-specific antibiotics that impair commensal colonization Open
Streptococcus mutans is a common constituent of dental plaque and an etiologic agent of dental caries (tooth decay). Here we elucidate a biosynthetic pathway, encoded by globally distributed strains of S. mutans , which produces a series o…
View article: Bacteria-to-human protein networks reveal origins of endogenous DNA damage
Bacteria-to-human protein networks reveal origins of endogenous DNA damage Open
SUMMARY DNA damage provokes mutations and cancer, and results from external carcinogens or endogenous cellular processes. Yet, the intrinsic instigators of DNA damage are poorly understood. Here we identify proteins that promote endogenous…