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View article: Polyneuropathy in hereditary and wildtype transthyretin amyloidosis, comparison of key clinical features and red flags
Polyneuropathy in hereditary and wildtype transthyretin amyloidosis, comparison of key clinical features and red flags Open
Transthyretin (TTR) amyloidosis manifests in two distinct forms: hereditary (ATTRv) and wild-type transthyretin amyloidosis (ATTRwt). Despite being one of the commonest manifestations in ATTRv amyloidosis, the presence of polyneuropathy ha…
View article: Idiopathic inflammatory myopathy associated with Sjögren’s disease: features of a distinct clinical entity
Idiopathic inflammatory myopathy associated with Sjögren’s disease: features of a distinct clinical entity Open
Background Idiopathic inflammatory myopathies (IIM) and Sjögren’s disease (SjD) may coexist, but data on their combined presentation and treatment response remain limited. Methods We retrospectively analyzed 23 patients with biopsy-confirm…
View article: Kappa free light chain concentration in serum is reduced after CD20-depletion with ocrelizumab
Kappa free light chain concentration in serum is reduced after CD20-depletion with ocrelizumab Open
Background Kappa free light chains (KFLC), a byproduct of immunoglobulin (Ig) synthesis by B-lineage cells, can serve as an indicator for inflammatory activity. In multiple sclerosis (MS), especially the intrathecal KFLC production has gai…
View article: Low triglyceride levels are associated with increased risk of immune-related adverse events in patients receiving immune checkpoint inhibitors
Low triglyceride levels are associated with increased risk of immune-related adverse events in patients receiving immune checkpoint inhibitors Open
Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy by enhancing anti-tumor immune responses, yet their use can lead to immune-related adverse events (irAE), including neurological complications. Despite their clinical re…
View article: Management of disease-modifying therapies in multiple sclerosis and comorbid rheumatoid arthritis
Management of disease-modifying therapies in multiple sclerosis and comorbid rheumatoid arthritis Open
View article: Complement activation profiles in patients with immune checkpoint inhibitor-associated neuromuscular immune-related adverse events
Complement activation profiles in patients with immune checkpoint inhibitor-associated neuromuscular immune-related adverse events Open
View article: Correction: Metabolomic profile of cerebrospinal fluid from patients with diffuse gliomas
Correction: Metabolomic profile of cerebrospinal fluid from patients with diffuse gliomas Open
View article: Directly Isolated Allogeneic Virus–Specific T Cells in Progressive Multifocal Leukoencephalopathy
Directly Isolated Allogeneic Virus–Specific T Cells in Progressive Multifocal Leukoencephalopathy Open
Importance Progressive multifocal leukoencephalopathy (PML) is a life-threatening viral infection with no approved antiviral treatment. Objective To determine whether restoring the compromised immune system of patients with PML with direct…
View article: Rapid depletion of CD20+ B and T cells following ofatumumab therapy onset
Rapid depletion of CD20+ B and T cells following ofatumumab therapy onset Open
Ofatumumab effectively depletes CD20+ lymphocytes already after the first administration. This depletion affects not only B cells, but also a small proportion of T cells (CD3+CD20+), affirming the hypothesi…
View article: Metabolomic profile of cerebrospinal fluid from patients with diffuse gliomas
Metabolomic profile of cerebrospinal fluid from patients with diffuse gliomas Open
View article: Targeted metabolomics identifies accurate CSF metabolite biomarkers for the differentiation between COVID-19 with neurological involvement and CNS infections with neurotropic viral pathogens
Targeted metabolomics identifies accurate CSF metabolite biomarkers for the differentiation between COVID-19 with neurological involvement and CNS infections with neurotropic viral pathogens Open
Background COVID-19 is primarily considered a respiratory tract infection, but it can also affect the central nervous system (CNS), which can result in long-term sequelae. In contrast to CNS infections by classic neurotropic viruses, SARS-…
View article: Combined treatment with allogeneic Epstein–Barr- and human polyomavirus 1 specific T-cells in progressive multifocal leukoencephalopathy and EBV infection: a case report
Combined treatment with allogeneic Epstein–Barr- and human polyomavirus 1 specific T-cells in progressive multifocal leukoencephalopathy and EBV infection: a case report Open
Opportunistic viral infections in individuals with severe immunodeficiency can lead to fatal conditions such as progressive multifocal leukoencephalopathy (PML), for which treatment options are limited. These infections pose significant ri…
View article: Rapid Pacing Decreases L-type Ca2+ Current and Alters Cacna1c Isogene Expression in Primary Cultured Rat Left Ventricular Myocytes
Rapid Pacing Decreases L-type Ca2+ Current and Alters Cacna1c Isogene Expression in Primary Cultured Rat Left Ventricular Myocytes Open
The L-type calcium current (I CaL ) is the first step in cardiac excitation–contraction-coupling and plays an important role in regulating contractility, but also in electrical and mechanical remodeling. Primary culture of cardiomyocytes, …
View article: PD-1-inhibitor pembrolizumab for treatment of progressive multifocal leukoencephalopathy
PD-1-inhibitor pembrolizumab for treatment of progressive multifocal leukoencephalopathy Open
The reactivation of human JC polyoma virus (JCPyV) results in lytic infection of oligodendrocytes and neuronal cells. The corresponding clinical picture is called progressive multifocal leukoencephalopathy (PML) and results mostly from a d…
View article: Glucocorticoids preserve the t-tubular system in ventricular cardiomyocytes by upregulation of autophagic flux
Glucocorticoids preserve the t-tubular system in ventricular cardiomyocytes by upregulation of autophagic flux Open