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View article: Effect of High BMI on Human Bone Marrow–Derived Mesenchymal Stromal Cells
Effect of High BMI on Human Bone Marrow–Derived Mesenchymal Stromal Cells Open
Bone marrow–derived mesenchymal stromal cells (BMSCs) are attractive candidates in tissue engineering and regenerative medicine. Growing evidence has suggested that a high body mass index (BMI) can affect the properties of BMSCs, resulting…
View article: Characterization of Human, Ovine and Porcine Mesenchymal Stem Cells from Bone Marrow: Critical In Vitro Comparison with Regard to Humans
Characterization of Human, Ovine and Porcine Mesenchymal Stem Cells from Bone Marrow: Critical In Vitro Comparison with Regard to Humans Open
For research and clinical use of stem cells, a suitable animal model is necessary. Hence, the aim of this study was to compare human-bone-marrow-derived mesenchymal stem cells (hBMSCs) with those from sheep (oBMSCs) and pigs (pBMSCs). The …
View article: Are the Properties of Bone Marrow-Derived Mesenchymal Stem Cells Influenced by Overweight and Obesity?
Are the Properties of Bone Marrow-Derived Mesenchymal Stem Cells Influenced by Overweight and Obesity? Open
Bone marrow-derived mesenchymal stem cells (BMSCs) are promising candidates for cell-based therapies. Growing evidence has indicated that overweight/obesity can change the bone marrow microenvironment, which affects some properties of BMSC…
View article: Influence of age on stem cells depends on the sex of the bone marrow donor
Influence of age on stem cells depends on the sex of the bone marrow donor Open
Ageing is often accompanied by an increase in bone marrow fat together with reduced bone volume and diseases of the bone such as osteoporosis. As mesenchymal stem cells (MSCs) are capable of forming bone, cartilage and fat tissue, studying…
View article: Cytological Effects of Serum Isolated from Polytraumatized Patients on Human Bone Marrow-Derived Mesenchymal Stem Cells
Cytological Effects of Serum Isolated from Polytraumatized Patients on Human Bone Marrow-Derived Mesenchymal Stem Cells Open
Due to their immunomodulatory and regenerative capacity, human bone marrow-derived mesenchymal stem cells (hBMSCs) are promising in the treatment of patients suffering from polytrauma. However, few studies look at the effects of sera from …
View article: Characteristics of Mesenchymal Stem Cells Are Independent of Bone Marrow Storage Temperatures
Characteristics of Mesenchymal Stem Cells Are Independent of Bone Marrow Storage Temperatures Open
Mesenchymal stem cells play an important role in regenerative medicine due to their capability of self-renewal and multipotent differentiation. For research or clinical application, bone marrow aspirates are harvested during elective surge…
View article: Osteoporosis is accompanied by reduced CD274 expression in human bone marrow-derived mesenchymal stem cells
Osteoporosis is accompanied by reduced CD274 expression in human bone marrow-derived mesenchymal stem cells Open
Underlying pathomechanisms of osteoporosis are still not fully elucidated. Cell-based therapy approaches pose new possibilities to treat osteoporosis and its complications. The aim of this study was to quantify differences in human bone ma…
View article: Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development
Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development Open
Tissue accumulation of p16INK4a-positive senescent cells is associated with age-related disorders, such as osteoarthritis (OA). These cell-cycle arrested cells affect tissue function through a specific secretory phenotype. The links betwee…
View article: Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils
Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils Open
Significance Located at the apical (blood-facing) site of brain capillary endothelial cells that form the blood–brain barrier (BBB), the efflux transporter P-glycoprotein (Pgp) restricts the brain entry of various lipophilic xenobiotics, w…
View article: Screening by Social Workers in Medical Patients with Risk of Post-Acute Care Needs: A Stepped Wedge Cluster Randomized Trial / Evaluation eines Screenings durch Sozialarbeiter bei medizinischen Patienten mit einem Risiko für post-akuten Nachsorgebedarf: eine stepped wedge clusterrandomisierte Studie
Screening by Social Workers in Medical Patients with Risk of Post-Acute Care Needs: A Stepped Wedge Cluster Randomized Trial / Evaluation eines Screenings durch Sozialarbeiter bei medizinischen Patienten mit einem Risiko für post-akuten Nachsorgebedarf: eine stepped wedge clusterrandomisierte Studie Open
Background Elderly patients often need post-acute care after hospital discharge. Involvement of social workers can positively affect the discharge planning process. Aim To investigate the effect of screening patients at risk for post-acute…
View article: Differential Expression of Cholinergic System Components in Human Induced Pluripotent Stem Cells, Bone Marrow-Derived Multipotent Stromal Cells, and Induced Pluripotent Stem Cell-Derived Multipotent Stromal Cells
Differential Expression of Cholinergic System Components in Human Induced Pluripotent Stem Cells, Bone Marrow-Derived Multipotent Stromal Cells, and Induced Pluripotent Stem Cell-Derived Multipotent Stromal Cells Open
The components of the cholinergic system are evolutionary very old and conserved molecules that are expressed in typical spatiotemporal patterns. They are involved in signaling in the nervous system, whereas their functions in nonneuronal …
View article: Severe Hemorrhagic Shock Leads to a Delayed Fracture Healing and Decreased Bone Callus Strength in a Mouse Model
Severe Hemorrhagic Shock Leads to a Delayed Fracture Healing and Decreased Bone Callus Strength in a Mouse Model Open
A severe hemorrhagic shock in patients could result in initial delayed fracture healing and needs special attention. We plan to conduct a prospective, observational clinical research study to analyze if delayed fracture healing occurs in p…
View article: Two-stage late reconstruction with a fresh large osteochondral shell allograft transplantation (FLOCSAT) for a large ostechondral defect in a non-union after a lateral tibia plateau fracture 2-year follow up
Two-stage late reconstruction with a fresh large osteochondral shell allograft transplantation (FLOCSAT) for a large ostechondral defect in a non-union after a lateral tibia plateau fracture 2-year follow up Open
This is the description of a 58-year-old female patient presenting 8 months after a horse riding accident with significant pain and inability to walk independently. Imaging revealed a large osseous defect of the lateral tibia plateau which…
View article: Intercellular transfer of P-glycoprotein in human blood-brain barrier endothelial cells is increased by histone deacetylase inhibitors
Intercellular transfer of P-glycoprotein in human blood-brain barrier endothelial cells is increased by histone deacetylase inhibitors Open
The blood–brain barrier (BBB) controls the entry of compounds into the brain, thereby regulating brain homeostasis. Efflux transporters such as P-glycoprotein (Pgp) significantly contribute to BBB function. Multiple signaling pathways modu…
View article: Expression of CD24 in Human Bone Marrow‐Derived Mesenchymal Stromal Cells Is Regulated by TGF<i>β</i>3 and Induces a Myofibroblast‐Like Genotype
Expression of CD24 in Human Bone Marrow‐Derived Mesenchymal Stromal Cells Is Regulated by TGF<i>β</i>3 and Induces a Myofibroblast‐Like Genotype Open
Human bone marrow‐derived stromal cells (hBMSCs) derived from the adult organism hold great promise for diverse settings in regenerative medicine. Therefore a more complete understanding of hBMSC biology to fully exploit the cells’ potenti…
View article: Inhibition distribution of the <i>in vitro</i> screenings.
Inhibition distribution of the <i>in vitro</i> screenings. Open
The number of compounds is plotted against the percentage of TR inhibition. The grey area represents the activity distribution of the compounds in the initial screening, while the white area shows the distribution of the second in vitro sc…
View article: TR-catalyzed reduction of trypanothione disulfide (TS<sub>2</sub>) to the dithiol trypanothione (T(SH)<sub>2</sub>).
TR-catalyzed reduction of trypanothione disulfide (TS<sub>2</sub>) to the dithiol trypanothione (T(SH)<sub>2</sub>). Open
TR-catalyzed reduction of trypanothione disulfide (TS2) to the dithiol trypanothione (T(SH)2).
View article: Treatment with mitomycin C (MMC) increases Pgp-EGFP fusion protein at the cell surface.
Treatment with mitomycin C (MMC) increases Pgp-EGFP fusion protein at the cell surface. Open
(A) hCMEC/D3-MDR1-EGFP (doxycycline-on) cells were treated with MMC (1 µM) for 2 or 4 h and analyzed at the end of the 2 h-exposure period or 20 h after the 4 h-exposure period. Western blot analyses of cell surface proteins isolated via E…