Sandra Pietsch
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View article: The long-term effects of chemotherapy on normal blood cells
The long-term effects of chemotherapy on normal blood cells Open
In developed countries, ∼10% of individuals are exposed to systemic chemotherapy for cancer and other diseases. Many chemotherapeutic agents act by increasing DNA damage in cancer cells, triggering cell death. However, there is limited und…
View article: Supplementary Table S2 from Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis
Supplementary Table S2 from Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis Open
Supplementary Table S2
View article: Supplementary Table S2 from Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis
Supplementary Table S2 from Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis Open
Supplementary Table S2
View article: Data from Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis
Data from Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis Open
Nitric oxide (NO) is a signaling molecule produced by NO synthases (NOS1–3) to control processes such as neurotransmission, vascular permeability, and immune function. Although myeloid cell–derived NO has been shown to suppress T-cell resp…
View article: Supplementary Figures and Tables S1 and S3 from Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis
Supplementary Figures and Tables S1 and S3 from Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis Open
Supplementary Figures S1-S6, Supplementary Tables S1 and S3, and uncropped western blot images.
View article: Data from Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis
Data from Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis Open
Nitric oxide (NO) is a signaling molecule produced by NO synthases (NOS1–3) to control processes such as neurotransmission, vascular permeability, and immune function. Although myeloid cell–derived NO has been shown to suppress T-cell resp…
View article: Supplementary Figures and Tables S1 and S3 from Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis
Supplementary Figures and Tables S1 and S3 from Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis Open
Supplementary Figures S1-S6, Supplementary Tables S1 and S3, and uncropped western blot images.
View article: Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis
Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis Open
Nitric oxide (NO) is a signaling molecule produced by NO synthases (NOS1–3) to control processes such as neurotransmission, vascular permeability, and immune function. Although myeloid cell–derived NO has been shown to suppress T-cell resp…
View article: The S enantiomer of 2-hydroxyglutarate increases central memory CD8 populations and improves CAR-T therapy outcome
The S enantiomer of 2-hydroxyglutarate increases central memory CD8 populations and improves CAR-T therapy outcome Open
Cancer immunotherapy is advancing rapidly and gene-modified T cells expressing chimeric antigen receptors (CARs) show particular promise. A challenge of CAR-T cell therapy is that the ex vivo–generated CAR-T cells become exhausted during e…
View article: 2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia
2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia Open
The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the metabolite 2-hydroxyglutarate (2HG) is dramatically suppressed following lipopolysaccharide (LPS) administration in …
View article: 2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia.
2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia. Open
The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the metabolite 2-hydroxyglutarate (2HG) is dramatically suppressed following lipopolysaccharide (LPS) administration in …
View article: Metabolite X is a novel biomarker for sepsis diagnosis and treatment
Metabolite X is a novel biomarker for sepsis diagnosis and treatment Open
Background: Sepsis develops when the initial, appropriate host response to an infection becomes amplified and subsequently dysregulated. Recent research has shown that the pathogenesis of sepsis can only partially be explained by an aberra…