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View article: Perceiving less or perceiving unreliably? Disentangling thermosensory sensitivity and precision in the contexts of ageing and neuropathy
Perceiving less or perceiving unreliably? Disentangling thermosensory sensitivity and precision in the contexts of ageing and neuropathy Open
Thermal perception is determined not only by sensitivity but also by precision, yet the latter is often overlooked in thermosensation and pain research. This study examined how ageing and diabetic polyneuropathy (DPN) affect the sensitivit…
View article: The Effect of Fremanezumab on Pain in Patients with Complex Regional Pain Syndrome: Study Protocol of a Randomized, Double-Blind, Proof-of-Concept, Placebo-Controlled Trial
The Effect of Fremanezumab on Pain in Patients with Complex Regional Pain Syndrome: Study Protocol of a Randomized, Double-Blind, Proof-of-Concept, Placebo-Controlled Trial Open
Background/Objectives: Complex regional pain syndrome (CRPS) is a primary pain condition that can develop in a limb after a trauma. Although the condition is rare, it may cause lifelong pain and disability. Evidence-based treatments are li…
View article: Barriers and new opportunities in developing effective therapies for diabetic neuropathy: International expert consensus recommendations
Barriers and new opportunities in developing effective therapies for diabetic neuropathy: International expert consensus recommendations Open
Successful interventional trials require robust outcome measures to capture clinically meaningful changes in DN phenotypes, providing the basis for developing effective, disease-modifying treatments.
View article: Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort
Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort Open
We aimed to investigate the genetic associations of neuropathic pain in a deeply phenotyped cohort. Participants with neuropathic pain were cases and compared with those exposed to injury or disease but without neuropathic pain as control …
View article: Cardiovascular autonomic neuropathy in patients with type 2 diabetes with and without sensorimotor polyneuropathy
Cardiovascular autonomic neuropathy in patients with type 2 diabetes with and without sensorimotor polyneuropathy Open
Background and Aims Cardiovascular autonomic neuropathy (CAN) in patients with diabetes is associated with poor prognosis. We aimed to assess signs of CAN and autonomic symptoms and to investigate the impact of sensorimotor neuropathy on C…
View article: Assessing Corneal Confocal Microscopy and Other Small Fiber Measures in Diabetic Polyneuropathy
Assessing Corneal Confocal Microscopy and Other Small Fiber Measures in Diabetic Polyneuropathy Open
This study provides Class III evidence that CCM measures aid in the detection of DPN in recently diagnosed type 2 diabetics but with a low sensitivity when compared with other small fiber measures.
View article: Characteristics and Treatment of Painful Diabetic Neuropathy
Characteristics and Treatment of Painful Diabetic Neuropathy Open
The most common of painful diabetic neuropathies is painful polyneuropathy, affecting up to 50% of patients with polyneuropathy. The risk factors for developing neuropathic pain in those with diabetic polyneuropathy are largely unknown. In…
View article: The characteristics of pain and dysesthesia in patients with diabetic polyneuropathy
The characteristics of pain and dysesthesia in patients with diabetic polyneuropathy Open
Introduction/aims Patients with diabetic polyneuropathy (DPN) may experience paresthesia, dysesthesia, and pain. We aimed to characterize the predictors, symptoms, somatosensory profile, neuropathy severity, and impact of painful DPN and d…
View article: Axonal Excitability Does Not Differ between Painful and Painless Diabetic or Chemotherapy‐Induced Distal Symmetrical Polyneuropathy in a Multicenter Observational Study
Axonal Excitability Does Not Differ between Painful and Painless Diabetic or Chemotherapy‐Induced Distal Symmetrical Polyneuropathy in a Multicenter Observational Study Open
Objective Axonal excitability reflects ion channel function, and it is proposed that this may be a biomarker in painful (vs painless) polyneuropathy. Our objective was to investigate the relationship between axonal excitability parameters …
View article: Test‐retest and time dependent variation and diagnostic values of vibratory sensation determined by biothesiometer and the Rydel‐Seiffer tuning fork
Test‐retest and time dependent variation and diagnostic values of vibratory sensation determined by biothesiometer and the Rydel‐Seiffer tuning fork Open
Background and aims Polyneuropathy is a common neurological disorder with many potential causes. An essential part in screening, diagnosis, and follow‐up evaluation of polyneuropathy is testing of the sensory function including vibratory s…
View article: Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management
Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management Open
Peripheral neuropathy is one of the most common complications of both type 1 and type 2 diabetes. Up to half of patients with diabetes develop neuropathy during the course of their disease, which is accompanied by neuropathic pain in 30–40…
View article: Axonal swellings are related to type 2 diabetes, but not to distal diabetic sensorimotor polyneuropathy
Axonal swellings are related to type 2 diabetes, but not to distal diabetic sensorimotor polyneuropathy Open
View article: Normative reference values for the dorsal sural nerve derived from a large multicenter cohort
Normative reference values for the dorsal sural nerve derived from a large multicenter cohort Open
View article: Small and large fiber sensory polyneuropathy in type 2 diabetes: Influence of diagnostic criteria on neuropathy subtypes
Small and large fiber sensory polyneuropathy in type 2 diabetes: Influence of diagnostic criteria on neuropathy subtypes Open
Diabetic polyneuropathy (DPN) can be classified based on fiber diameter into three subtypes: small fiber neuropathy (SFN), large fiber neuropathy (LFN), and mixed fiber neuropathy (MFN). We examined the effect of different diagnostic model…
View article: Diabetic polyneuropathy and neuropathic pain: findings from a qualitative study
Diabetic polyneuropathy and neuropathic pain: findings from a qualitative study Open
Diabetic polyneuropathy and painful diabetic polyneuropathy are common long‐term complications of diabetes. The purpose of this qualitative study was to explore the impact of diabetic polyneuropathy and painful diabetic polyneuropathy symp…
View article: Diagnosis and prevalence of diabetic polyneuropathy: a cross‐sectional study of Danish patients with type 2 diabetes
Diagnosis and prevalence of diabetic polyneuropathy: a cross‐sectional study of Danish patients with type 2 diabetes Open
Background and purpose Diabetic polyneuropathy (DPN) is a common complication of diabetes. Using the Toronto criteria for diabetic polyneuropathy and the grading system for neuropathic pain, the performance of neuropathy scales and questio…
View article: Metabolic factors, lifestyle habits, and possible polyneuropathy in early type 2 diabetes: A nationwide study of 5,249 patients in the Danish DD2 cohort
Metabolic factors, lifestyle habits, and possible polyneuropathy in early type 2 diabetes: A nationwide study of 5,249 patients in the Danish DD2 cohort Open
OBJECTIVE:To investigate the association of metabolic and lifestyle factors with possible diabetic polyneuropathy (DPN) and neuropathic pain in patients with early type 2 diabetes. RESEARCH DESIGN AND METHODS: We thoroughly characterized 6…
View article: Metabolic factors, lifestyle habits, and possible polyneuropathy in early type 2 diabetes: A nationwide study of 5,249 patients in the Danish DD2 cohort
Metabolic factors, lifestyle habits, and possible polyneuropathy in early type 2 diabetes: A nationwide study of 5,249 patients in the Danish DD2 cohort Open
OBJECTIVE:To investigate the association of metabolic and lifestyle factors with possible diabetic polyneuropathy (DPN) and neuropathic pain in patients with early type 2 diabetes. RESEARCH DESIGN AND METHODS: We thoroughly characterized 6…
View article: Diabetic foot distress: we should pay attention
Diabetic foot distress: we should pay attention Open
Many people suffering from diabetes, unfortunately, develop comorbidities, meaning that they struggle with both chronic illness and multimorbidity. Several qualitative studies have examined the multiple ways in which a diabetes-related dia…
View article: Diabetic polyneuropathy and pain, prevalence, and patient characteristics: a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes
Diabetic polyneuropathy and pain, prevalence, and patient characteristics: a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes Open
Most studies of diabetic polyneuropathy (DPN) and painful DPN are conducted in persons with longstanding diabetes. This cross-sectional study aimed to estimate the prevalence of DPN and painful DPN, important risk factors, and the associat…
View article: Detection of early motor involvement in diabetic polyneuropathy using a novel MUNE method – MScanFit MUNE
Detection of early motor involvement in diabetic polyneuropathy using a novel MUNE method – MScanFit MUNE Open
View article: Painful and non‐painful diabetic polyneuropathy: Clinical characteristics and diagnostic issues
Painful and non‐painful diabetic polyneuropathy: Clinical characteristics and diagnostic issues Open
Diabetic neuropathy (DN) is a common complication of diabetes and can be either painful or non‐painful. It is challenging to diagnose this complication, as no biomarker or clear consensus on the clinical definition of either painful or non…
View article: A PRPH splice-donor variant associates with reduced sural nerve amplitude and risk of peripheral neuropathy
A PRPH splice-donor variant associates with reduced sural nerve amplitude and risk of peripheral neuropathy Open