Sandra Specht
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View article: Structure-function analysis and membrane association of Leishmania tarentolae and Plasmodium falciparum Erv
Structure-function analysis and membrane association of Leishmania tarentolae and Plasmodium falciparum Erv Open
Throughout evolution most of the mitochondrial genes have been transferred to the nuclear genome. Thus, proteins targeting one of the four mitochondrial compartments have to be translocated after their synthesis in the cytosol. This proces…
View article: Tyrosine substitution of a conserved active‐site histidine residue activates <i>Plasmodium falciparum</i> peroxiredoxin 6
Tyrosine substitution of a conserved active‐site histidine residue activates <i>Plasmodium falciparum</i> peroxiredoxin 6 Open
Peroxiredoxins efficiently remove hydroperoxides and peroxynitrite in pro‐ and eukaryotes. However, isoforms of one subfamily of peroxiredoxins, the so‐called Prx6‐type enzymes, usually have very low activities in standard peroxidase assay…
View article: A single-cysteine mutant and chimeras of essential Leishmania Erv can complement the loss of Erv1 but not of Mia40 in yeast
A single-cysteine mutant and chimeras of essential Leishmania Erv can complement the loss of Erv1 but not of Mia40 in yeast Open
Mia40/CHCHD4 and Erv1/ALR are essential for oxidative protein folding in the mitochondrial intermembrane space of yeast and mammals. In contrast, many protists, including important apicomplexan and kinetoplastid parasites, lack Mia40. Furt…