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View article: Mechanism and regulation of secondary immunoglobulin diversification
Mechanism and regulation of secondary immunoglobulin diversification Open
Secondary immunoglobulin diversification by somatic hypermutation and class switch recombination in B cells is instrumental for an adequate adaptive humoral immune response. These genetic events may, however, also introduce aberrations int…
View article: Restriction of AID activity and somatic hypermutation by PARP-1
Restriction of AID activity and somatic hypermutation by PARP-1 Open
Affinity maturation of the humoral immune response depends on somatic hypermutation (SHM) of immunoglobulin (Ig) genes, which is initiated by targeted lesion introduction by activation-induced deaminase (AID), followed by error-prone DNA r…
View article: PARP activation promotes nuclear AID accumulation in lymphoma cells
PARP activation promotes nuclear AID accumulation in lymphoma cells Open
Activation-induced cytidine deaminase (AID) initiates immunoglobulin diversification in germinal center B cells by targeted introduction of DNA damage. As aberrant nuclear AID action contributes to the generation of B cell lymphoma, the pr…