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View article: Unraveling sphingolipid dynamics in late-onset preeclampsia: insights from lipidomic analysis
Unraveling sphingolipid dynamics in late-onset preeclampsia: insights from lipidomic analysis Open
Introduction: Sphingolipids, essential to trophoblast and endothelial function, may impact inflammation in preeclampsia. However, their specific role in late-onset preeclampsia remains unclear. To address this research gap, we analyzed sph…
View article: The Effects of Pregestational Overweight and Obesity on Maternal Lipidome in Pregnancy: Implications for Newborns’ Characteristics
The Effects of Pregestational Overweight and Obesity on Maternal Lipidome in Pregnancy: Implications for Newborns’ Characteristics Open
Obesity is an important risk factor for the development of pregnancy complications. We investigated the effects of pregestational overweight and obesity on maternal lipidome during pregnancy and on newborns’ characteristics. The study enco…
View article: Targeting noncoding RNAs to treat atherosclerosis
Targeting noncoding RNAs to treat atherosclerosis Open
Noncoding RNAs (ncRNAs) are pivotal for various pathological processes, impacting disease progression. The potential for leveraging ncRNAs to prevent or treat atherosclerosis and associated cardiovascular diseases is of great significance,…
View article: The influence of various sample storage conditions and sample bacterial contamination on concentrations of routine biochemical parameters
The influence of various sample storage conditions and sample bacterial contamination on concentrations of routine biochemical parameters Open
Background: The pre-analytical (PA) phase is the most vulnerable phase of the laboratory testing procedure, with critical procedures-collection, handling, sample transport, and time and temperature of sample storage. This study aimed to ex…
View article: HDL – associated proteins in hypertensive disorders of pregnancy
HDL – associated proteins in hypertensive disorders of pregnancy Open
Summary. Hypertensive disorders of pregnancy are associated with various complications and long-term health risks for both mother and child. Preeclampsia, a form of hypertensive disorder, is characterized by gestational hy…
View article: LncRNAs as Regulators of Atherosclerotic Plaque Stability
LncRNAs as Regulators of Atherosclerotic Plaque Stability Open
Current clinical data show that, despite constant efforts to develop novel therapies and clinical approaches, atherosclerotic cardiovascular diseases (ASCVD) are still one of the leading causes of death worldwide. Advanced and unstable ath…
View article: Cholesterol Metabolic Profiling of HDL in Women with Late-Onset Preeclampsia
Cholesterol Metabolic Profiling of HDL in Women with Late-Onset Preeclampsia Open
A specific feature of dyslipidemia in pregnancy is increased high-density lipoprotein (HDL) cholesterol concentration, which is probably associated with maternal endothelium protection. However, preeclampsia is most often associated with l…
View article: Biochemical and hematological parameters in the 1st trimester of pregnancy
Biochemical and hematological parameters in the 1st trimester of pregnancy Open
The 1st trimester of pregnancy is accompanied with changes in different biochemical and hematological parameters. Analyses scheduled to be performed in the 1st trimester are complete blood count, blood group, Rh factor and the double test.…
View article: Effects of Gestational Diabetes Mellitus on Cholesterol Metabolism in Women with High-Risk Pregnancies: Possible Implications for Neonatal Outcome
Effects of Gestational Diabetes Mellitus on Cholesterol Metabolism in Women with High-Risk Pregnancies: Possible Implications for Neonatal Outcome Open
Metabolic disorders in pregnancy, particularly gestational diabetes mellitus (GDM), are associated with an increased risk for adverse pregnancy outcome and long-term cardiometabolic health of mother and child. This study analyzed changes o…
View article: Lipoproteins and cholesterol homeostasis in paediatric nephrotic syndrome patients
Lipoproteins and cholesterol homeostasis in paediatric nephrotic syndrome patients Open
The aim of this study was to investigate lipoprotein particle distributions and the likelihood of achieving cholesterol homeostasis in the remission phase of nephrotic syndrome (NS) in paediatric patients. We hypothesized that lipoprotein …
View article: Biomarkers of vitamin D status in healthy adults: Associations with serum lipid parameters: A pilot study
Biomarkers of vitamin D status in healthy adults: Associations with serum lipid parameters: A pilot study Open
Vitamin D deficiency is among important healthcare challenges today. Traditionally, vitamin D status is assessed through determination of 25-hydroxy metabolite (25(OH)D), but novel data point to 24,25(OH)2D and 25(OH)D/24,25(OH)2D ratio (V…
View article: Revealing the Role of High-Density Lipoprotein in Colorectal Cancer
Revealing the Role of High-Density Lipoprotein in Colorectal Cancer Open
Colorectal cancer (CRC) is a highly prevalent malignancy with multifactorial etiology, which includes metabolic alterations as contributors to disease development. Studies have shown that lipid status disorders are involved in colorectal c…
View article: Antioxidant, anti-inflammatory, and anti-hyperlipidemic properties of the spelt grass juice
Antioxidant, anti-inflammatory, and anti-hyperlipidemic properties of the spelt grass juice Open
Spelt is a grain rich in bioactive compounds - different phytochemicals, so it is often mentioned in the context of being beneficial to human health. We aimed to investigate the antioxidant, anti-inflammatory, and anti-hyperlipidemic prope…
View article: Validation of a quick and simple chromatographic method for simultaneous quantification of sertraline, escitalopram, risperidone and paliperidone levels in the human plasma
Validation of a quick and simple chromatographic method for simultaneous quantification of sertraline, escitalopram, risperidone and paliperidone levels in the human plasma Open
Simultaneous quantification of multiple psychiatric drugs is important for the therapeutic drug monitoring of psychiatric patients. In addition, it would be highly advantageous if the method could be simple, straightforward, and not time-c…
View article: Determination of non-cholesterol sterols in serum and HDL fraction by LC/MS-ms: Significance of matrix-related interferences
Determination of non-cholesterol sterols in serum and HDL fraction by LC/MS-ms: Significance of matrix-related interferences Open
Summary Background Non-cholesterol sterols (NCS) are promising biomarkers for estimation of cholesterol homeostasis properties. In addition, determination of NCS in high-density lipoprotein (HDL) fraction (HDL-NCS) could provide informatio…
View article: Associations of cholesterol and vitamin D metabolites with the risk for development of high grade colorectal cancer
Associations of cholesterol and vitamin D metabolites with the risk for development of high grade colorectal cancer Open
Summary Background Vitamin D deficiency is repeatedly reported in colorectal cancer (CRC). Since cholesterol and vitamin D share common precursor 7-dehydrocholesterol (7-DHC), it would be important to explore the associations of key vitami…
View article: Cardiometabolic and antioxidative effects of lyophilized goat whey supplementation
Cardiometabolic and antioxidative effects of lyophilized goat whey supplementation Open
Milk and dairy products exhibit a beneficial nutritional and health effects and represent 20% to 30% of global food consumption. Whey proteins have great anabolic and cardioprotective role. Increased concentration of cholesterol contained …
View article: Changes in lecithin: cholesterol acyltransferase, cholesteryl ester transfer protein and paraoxonase-1 activities in patients with colorectal cancer
Changes in lecithin: cholesterol acyltransferase, cholesteryl ester transfer protein and paraoxonase-1 activities in patients with colorectal cancer Open
Our results demonstrated increased CETP and decreased LCAT and PON-1 activities in CRC patients. In preliminary analysis CETP mass was identified as potential significant predictor of CRC development, suggesting that alterations in HDL-C l…