Sandrine Houzé
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View article: Significance of positive semi-quantitative PCR tests on bronchoalveolar lavage for Pneumocystis jirovecii pneumonia in HIV-negative immunocompromised ICU patients with acute respiratory failure
Significance of positive semi-quantitative PCR tests on bronchoalveolar lavage for Pneumocystis jirovecii pneumonia in HIV-negative immunocompromised ICU patients with acute respiratory failure Open
Context Real-time PCR (rt-PCR) using cycle threshold (Ct) is a semi-quantitative way to assess DNA amounts, which has become broadly used to diagnose Pneumocystis jirovecii pneumonia (PJP) in non-HIV immunocompromised patients. We aimed to…
View article: Comparison of the composition and antiplasmodial activity of Artemisia annua teas using an untargeted metabolomic approach
Comparison of the composition and antiplasmodial activity of Artemisia annua teas using an untargeted metabolomic approach Open
The use of teas made from locally cultivated Artemisia annua to fight malaria in remote areas where access to care is difficult is a matter of debate. This study aimed at document differences in the composition of A. annua teas cultivated …
View article: Assessment of ex vivo antimalarial drug efficacy in African Plasmodium falciparum parasite isolates, 2016–2023: a genotype–phenotype association study
Assessment of ex vivo antimalarial drug efficacy in African Plasmodium falciparum parasite isolates, 2016–2023: a genotype–phenotype association study Open
View article: Identification of <i>Toxoplasma gondii</i> antigenic proteins using an <i>in vivo</i> approach and <i>in silico</i> investigation of their polymorphism
Identification of <i>Toxoplasma gondii</i> antigenic proteins using an <i>in vivo</i> approach and <i>in silico</i> investigation of their polymorphism Open
Toxoplasma gondii is a pathogen characterized by a large variety of strains whose virulence and clinical severity are likely linked to their genotype. Currently, the strains are genotyped using restriction fragment length polymorphism, mul…
View article: Imported loiasis: Diagnostic and therapeutic challenges
Imported loiasis: Diagnostic and therapeutic challenges Open
View article: Clarification of factors associated with post-artesunate delayed hemolysis (PADH): Analysis of 327 patients with severe imported Plasmodium falciparum malaria in France
Clarification of factors associated with post-artesunate delayed hemolysis (PADH): Analysis of 327 patients with severe imported Plasmodium falciparum malaria in France Open
This study showed that initial parasitemia and patient origin were the main predictors of developing PADH, with the highest risk observed in Europeans with an initial parasitemia >10 %.
View article: Implementation and validation of a new qPCR assay to detect imported human <i>Plasmodium</i> species
Implementation and validation of a new qPCR assay to detect imported human <i>Plasmodium</i> species Open
Diagnosis of imported malaria is based on microscopic examination of blood smears (BS), detection of circulating plasmodial antigen by immunochromatography (ICT), or detection of Plasmodium spp. DNA by loop mediated isothermal amplificatio…
View article: Airport and luggage (Odyssean) malaria in Europe: a systematic review
Airport and luggage (Odyssean) malaria in Europe: a systematic review Open
Background Airport and luggage (also called Odyssean) malaria are chance events where Plasmodium infection results from the bite of an infected mosquito which was transported by aircraft from a malaria-endemic area. Infrequent case reports…
View article: Locally acquired malaria: a retrospective analysis of long-term surveillance data, European France, 1995 to 2022
Locally acquired malaria: a retrospective analysis of long-term surveillance data, European France, 1995 to 2022 Open
Background In European France, the bulk of malaria cases are travel-related, and only locally acquired cases are notifiable to assess any risk of re-emergence. Aims We aimed to contribute to assessing the health impact of locally acquired …
View article: Ex vivo susceptibility to antimalarial drugs and polymorphisms in drug resistance genes of African Plasmodium falciparum, 2016-2023: a genotype-phenotype association study
Ex vivo susceptibility to antimalarial drugs and polymorphisms in drug resistance genes of African Plasmodium falciparum, 2016-2023: a genotype-phenotype association study Open
View article: <i>Ex vivo</i>susceptibility to antimalarial drugs and polymorphisms in drug resistance genes of African<i>Plasmodium falciparum</i>, 2016-2023: a genotype-phenotype association study
<i>Ex vivo</i>susceptibility to antimalarial drugs and polymorphisms in drug resistance genes of African<i>Plasmodium falciparum</i>, 2016-2023: a genotype-phenotype association study Open
Background Given the altered responses to both artemisinins and lumefantrine in Eastern Africa, monitoring antimalarial drug resistance in all African countries is paramount. Methods We measured the susceptibility to six antimalarials usin…
View article: Current knowledge and practice of Candida auris screening in France: A nationwide survey from the French Society of Medical Mycology (SFMM)
Current knowledge and practice of Candida auris screening in France: A nationwide survey from the French Society of Medical Mycology (SFMM) Open
Due to large outbreaks observed worldwide, Candida auris has emerged as a major threat to healthcare facilities. To prevent these phenomena, a systematic screening should be performed in patients transferred from regions where the pathogen…
View article: Monocytes, particularly nonclassical ones, lose their opsonic and nonopsonic phagocytosis capacity during pediatric cerebral malaria
Monocytes, particularly nonclassical ones, lose their opsonic and nonopsonic phagocytosis capacity during pediatric cerebral malaria Open
Introduction Innate immunity is crucial to reducing parasite burden and contributing to survival in severe malaria. Monocytes are key actors in the innate response and, like macrophages, are plastic cells whose function and phenotype are r…
View article: Plasmodium ovale spp dhfr mutations associated with reduced susceptibility to pyrimethamine in sub-Saharan Africa: a retrospective genetic epidemiology and functional study
Plasmodium ovale spp dhfr mutations associated with reduced susceptibility to pyrimethamine in sub-Saharan Africa: a retrospective genetic epidemiology and functional study Open
French Ministry of Health, Agence Nationale de la Recherche, and Global Emerging Infections Surveillance branch of the Armed Forces Health Surveillance Division.
View article: Genomic exploration of the complex journey of<i>Plasmodium vivax</i>in Latin America
Genomic exploration of the complex journey of<i>Plasmodium vivax</i>in Latin America Open
Plasmodium vivax , the predominant malaria parasite in Latin America, has a rich and complex colonization history in the region, with debated hypotheses about its origin. Our study employed cutting-edge population genomic techniques, to co…
View article: Comparative performance of ISAGA IgM and ELISA assays for the diagnosis of maternal and congenital <i>Toxoplasma</i> infections: which technique could replace ISAGA IgM?
Comparative performance of ISAGA IgM and ELISA assays for the diagnosis of maternal and congenital <i>Toxoplasma</i> infections: which technique could replace ISAGA IgM? Open
The ISAGA immunocapture test for the detection of anti- Toxoplasma immunoglobulin M is a manual technique known for its excellent sensitivity and specificity. The purpose of this retrospective, multicenter study was to compare the performa…
View article: Favorable outcome without corticosteroids during post-artesunate delayed hemolysis with positive direct antiglobulin test in severe imported Plasmodium falciparum malaria, France
Favorable outcome without corticosteroids during post-artesunate delayed hemolysis with positive direct antiglobulin test in severe imported Plasmodium falciparum malaria, France Open
View article: Chronic schistosomiasis imported in France: A retrospective multicentre analysis of 532 patients, calling for international recommendations
Chronic schistosomiasis imported in France: A retrospective multicentre analysis of 532 patients, calling for international recommendations Open
Approximately 50 % of patients with imported chronic schistosomiasis have radiological abnormalities, whether they are symptomatic or not, and management is heterogeneous. Multidisciplinary international guidelines are requested to clarify…
View article: Genetic diversity of <i>Plasmodium vivax</i> among immigrant patients exhibiting severe and non-severe clinical manifestations in northern suburbs of Paris
Genetic diversity of <i>Plasmodium vivax</i> among immigrant patients exhibiting severe and non-severe clinical manifestations in northern suburbs of Paris Open
Plasmodium vivax is the most frequent and widely distributed cause of recurring malaria. It is a public health issue that mostly occurs in Southeast Asia, followed by the Middle East, Latin, and South Americas and sub-Saharan Africa. Altho…
View article: Contribution of serology in congenital toxoplasmosis diagnosis: results from a 10-year French retrospective study
Contribution of serology in congenital toxoplasmosis diagnosis: results from a 10-year French retrospective study Open
This study aimed to evaluate different serological strategies for the postnatal diagnosis of congenital toxoplasmosis (CT) and establish a biological algorithm for CT diagnosis. The study analyzed serological data of immunoglobulins M, A, …
View article: Case series of intestinal microsporidiosis in non-HIV patients caused by <i>Encephalitozoon hellem</i>
Case series of intestinal microsporidiosis in non-HIV patients caused by <i>Encephalitozoon hellem</i> Open
Intestinal microsporidiosis is most often caused by Enterocytozoon bieneusi, and to a lesser extent by species of the genus Encephalitozoon. Until now, Encephalitozoon hellem was not clearly known to induce disease res…
View article: Molecular detection of human Plasmodium species using a multiplex real time PCR
Molecular detection of human Plasmodium species using a multiplex real time PCR Open
Molecular detection methods have revealed higher sensitivity and specificity than conventional microscopy or rapid diagnostic tests for malaria diagnosis. In this study, we implemented, evaluated and validated according to the ISO 15,189 r…
View article: Faecal Viral Excretion and Gastrointestinal Co-Infection Do Not Explain Digestive Presentation in COVID-19 Patients
Faecal Viral Excretion and Gastrointestinal Co-Infection Do Not Explain Digestive Presentation in COVID-19 Patients Open
The physiopathological mechanisms responsible for digestive symptoms in COVID-19 patients are still unclear. The aim of this study was to determine the influence of faecal viral shedding on digestive symptoms and propose differential diagn…
View article: Comparison of the Micronaut-AM System and the EUCAST Broth Microdilution Reference Method for MIC Determination of Four Antifungals against Aspergillus fumigatus
Comparison of the Micronaut-AM System and the EUCAST Broth Microdilution Reference Method for MIC Determination of Four Antifungals against Aspergillus fumigatus Open
The Antifungal Susceptibility Testing method of the European Committee on Antimicrobial Susceptibility Testing (EUCAST-AFST) is a reference technique for the determination of the Minimum Inhibitory Concentration (MIC) of antifungals for As…
View article: Plasmodium falciparum kelch13 polymorphisms identified after treatment failure with artemisinin-based combination therapy in Niger
Plasmodium falciparum kelch13 polymorphisms identified after treatment failure with artemisinin-based combination therapy in Niger Open
Background Artemisinin-based combination therapy (ACT) is the most effective treatment for malaria, and has significantly reduced morbimortality. Polymorphisms associated with the Plasmodium falciparum Kelch gene ( Pfkelch13 ) have been as…
View article: Novel paradigm enables accurate monthly gestational screening to prevent congenital toxoplasmosis and more
Novel paradigm enables accurate monthly gestational screening to prevent congenital toxoplasmosis and more Open
Background Congenital toxoplasmosis is a treatable, preventable disease, but untreated causes death, prematurity, loss of sight, cognition and motor function, and substantial costs worldwide. Methods/Findings In our ongoing USA feasibility…
View article: Genetic profiling of<i>Plasmodium ovale wallikeri</i>relapses with microsatellite markers and whole-genome sequencing
Genetic profiling of<i>Plasmodium ovale wallikeri</i>relapses with microsatellite markers and whole-genome sequencing Open
Like Plasmodium vivax , both Plasmodium ovale curtisi and Plasmodium ovale wallikeri have the ability to cause relapse in humans, defined as recurring asexual parasitaemia originating from liver dormant forms subsequent to a primary infect…
View article: Late dihydroartemisinin-piperaquine treatment failure of P. falciparum malaria attack related to insufficient dosing in an obese patient
Late dihydroartemisinin-piperaquine treatment failure of P. falciparum malaria attack related to insufficient dosing in an obese patient Open
We report the case of an obese patient who experienced late failure on day28 of a well-conducted treatment with artesunate, followed by dihydroartemisinin-piperaquine (DHA-PPQ) for a severe P. falciparum malaria attack. The same …
View article: IgM triplet in neonatal diagnosis by immunoblotting and its potential use as a diagnostic marker for congenital toxoplasmosis
IgM triplet in neonatal diagnosis by immunoblotting and its potential use as a diagnostic marker for congenital toxoplasmosis Open
Primary infection during pregnancy by the protozoan Toxoplasma gondii can be worrisome because transmission to the fetus may lead to congenital toxoplasmosis (CT). Neonatal diagnosis is usually performed by serological profile comparison o…
View article: Plasmodium falciparum Kelch13 polymorphisms identified after treatment failure with artemisinin- based combination therapy in Niger
Plasmodium falciparum Kelch13 polymorphisms identified after treatment failure with artemisinin- based combination therapy in Niger Open
Background: Artemisinin-based combination therapy (ACT) is the most effective treatment for malaria, and has significantly reduced morbimortality. Polymorphisms associated with the Plasmodium falciparum kelch gene ( Pfkelch13 ) propeller d…