Sandrine Marchand
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View article: Optimizing antimicrobial susceptibility testing: cost and environmental benefits of MIC volume reduction
Optimizing antimicrobial susceptibility testing: cost and environmental benefits of MIC volume reduction Open
The determination of minimum inhibitory concentrations (MICs) is essential for evaluating antimicrobial efficacy, guiding both clinical treatment decisions and drug development. The standard broth microdilution method is widely used but re…
View article: A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data
A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data Open
The main objective of this study was to validate an algorithm and experimental setup to simulate first-order absorption pharmacokinetic profiles without altering the standard in vitro hollow-fiber infection model (HFIM). For that, clinical…
View article: Optimizing Antimicrobial Susceptibility Testing: Cost and Environmental Benefits of MIC Volume Reduction
Optimizing Antimicrobial Susceptibility Testing: Cost and Environmental Benefits of MIC Volume Reduction Open
The determination of Minimum Inhibitory Concentrations (MICs) is essential for evaluating antimicrobial efficacy, guiding both clinical treatment decisions and drug development. The standard broth microdilution method is widely used but re…
View article: PKPD modeling of the inoculum effect of combined ceftazidime/avibactam and colistin against KPC-3 <i>Klebsiella pneumoniae</i> isolate
PKPD modeling of the inoculum effect of combined ceftazidime/avibactam and colistin against KPC-3 <i>Klebsiella pneumoniae</i> isolate Open
The inoculum effect (IE) characterizes a decrease in the antimicrobial effect of antibiotics with increasing inoculum. To face antimicrobial resistance, antibiotic combinations are progressively used. In this context, the effect of combina…
View article: <i>In vitro</i> pharmacokinetic/pharmacodynamic modeling of the effect of mucin on polymyxin B activity against <i>Acinetobacter baumannii</i>
<i>In vitro</i> pharmacokinetic/pharmacodynamic modeling of the effect of mucin on polymyxin B activity against <i>Acinetobacter baumannii</i> Open
The antibacterial efficacy of polymyxins in lungs may be impacted by mucin. The aim of this study was to characterize in vitro the effect of mucin on polymyxin B (PMB) activity against two multidrug-resistant Acinetobacter baumannii strain…
View article: The synergistic effect of the combination of polymyxin B and rifampicin in a murine neutropenic thigh infection model with <i>E. coli</i> and <i>K. pneumoniae</i>
The synergistic effect of the combination of polymyxin B and rifampicin in a murine neutropenic thigh infection model with <i>E. coli</i> and <i>K. pneumoniae</i> Open
Background Antibiotic combination therapy is increasingly used to treat MDR pathogens. In vitro studies suggest that the polymyxin B/rifampicin combination might be synergistic. Therefore, the pharmacodynamics of rifampicin as monotherapy …
View article: Prediction of higher ceftazidime–avibactam concentrations in the human renal interstitium compared with unbound plasma using a minimal physiologically based pharmacokinetic model developed in rats and pigs through microdialysis
Prediction of higher ceftazidime–avibactam concentrations in the human renal interstitium compared with unbound plasma using a minimal physiologically based pharmacokinetic model developed in rats and pigs through microdialysis Open
Last resort antibiotics, like ceftazidime–avibactam (CZA), were used to treat urinary tract infections caused by multidrug-resistant bacteria. However, no data on tissue distribution were available. Our aim was to describe the in vivo kidn…
View article: A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data
A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data Open
The main objective of this study was to validate an algorithm and experimental setup to simulate first-order absorption pharmacokinetic profiles without altering the standard in vitro hollow fiber infection model (HFIM). For that, clinical…
View article: CSF pharmacokinetics-pharmacodynamics of linezolid in critically brain injured patients, with or without central nervous system healthcare-associated infection. The PK-Pop-LCR Study: A Multicenter Pharmacokinetics and Pharmacodynamics Population Study
CSF pharmacokinetics-pharmacodynamics of linezolid in critically brain injured patients, with or without central nervous system healthcare-associated infection. The PK-Pop-LCR Study: A Multicenter Pharmacokinetics and Pharmacodynamics Population Study Open
Linezolid is an alternative to vancomycin for treating Gram-positive central nervous system (CNS) healthcare-associated infections. The recommended dosing regimen remains debated. PK-Pop-LCR is a prospective population pharmacokinetic-phar…
View article: Characterization and performance of the Apollon main short-pulse laser beam following its commissioning at 2 PW level
Characterization and performance of the Apollon main short-pulse laser beam following its commissioning at 2 PW level Open
We present the results of the second commissioning phase of the short-focal-length area of the Apollon laser facility (located in Saclay, France), which was performed with the main laser beam (F1), scaled to a peak power of 2 PetaWatt. Und…
View article: Emergence of cefiderocol resistance during therapy in NDM-5–producing Klebsiella pneumoniae isolates harboring siderophore receptors mutations
Emergence of cefiderocol resistance during therapy in NDM-5–producing Klebsiella pneumoniae isolates harboring siderophore receptors mutations Open
View article: (E, E)-farnesol and myristic acid-loaded lipid nanoparticles overcome colistin resistance in Acinetobacter baumannii
(E, E)-farnesol and myristic acid-loaded lipid nanoparticles overcome colistin resistance in Acinetobacter baumannii Open
View article: Assessment of inhaled cationic antibiotics in an in vitro model of Pseudomonas aeruginosa lung biofilm
Assessment of inhaled cationic antibiotics in an in vitro model of Pseudomonas aeruginosa lung biofilm Open
View article: In vitro efficacy of combinations of antibiotics used in clinical practice on clinical isolates of <i>Helicobacter pylori</i>
In vitro efficacy of combinations of antibiotics used in clinical practice on clinical isolates of <i>Helicobacter pylori</i> Open
Background The main antibiotics used against Helicobacter pylori have been chosen empirically over time, with few preclinical studies to provide support. The rise in resistance to some of these antibiotics is prompting a reassessment of th…
View article: Impact of nutritional factors on in vitro PK/PD modelling of polymyxin B against various strains of Acinetobacter baumannii
Impact of nutritional factors on in vitro PK/PD modelling of polymyxin B against various strains of Acinetobacter baumannii Open
View article: Evaluation of the Efficacy of Inhaled Cationic Antibiotics Using an in Vitro Model of Pseudomonas Aeruginosa Lung Biofilm
Evaluation of the Efficacy of Inhaled Cationic Antibiotics Using an in Vitro Model of Pseudomonas Aeruginosa Lung Biofilm Open
View article: Concentration‐dependent effect of amoxicillin against clinical strains of <i>Helicobacter pylori</i>
Concentration‐dependent effect of amoxicillin against clinical strains of <i>Helicobacter pylori</i> Open
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View article: Characterization of <i>Pseudomonas aeruginosa</i> resistance to ceftolozane-tazobactam due to <i>ampC</i> and/or <i>ampD</i> mutations observed during treatment using semi-mechanistic PKPD modeling
Characterization of <i>Pseudomonas aeruginosa</i> resistance to ceftolozane-tazobactam due to <i>ampC</i> and/or <i>ampD</i> mutations observed during treatment using semi-mechanistic PKPD modeling Open
A double ampC (AmpC G183D ) and ampD (AmpD H157Y ) genes mutations have been identified by whole genome sequencing in a Pseudomonas aeruginosa (PaS) that became resistant (PaR) in a patient treated by ceftolozane/tazobactam (C/T). To preci…
View article: An improved PKPD modeling approach to characterize the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin from <i>in vitro</i> time-kill experiments against multidrug-resistant <i>Klebsiella pneumoniae</i> isolates
An improved PKPD modeling approach to characterize the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin from <i>in vitro</i> time-kill experiments against multidrug-resistant <i>Klebsiella pneumoniae</i> isolates Open
In contrast to the checkerboard method, bactericidal experiments [time-kill curves (TKCs)] allow an assessment of pharmacodynamic (PD) interactions over time. However, TKCs in combination pose interpretation problems. The objective of this…
View article: Draft Genome Sequence of the Rhinocladiella similis Clinical Isolate CBS 149759
Draft Genome Sequence of the Rhinocladiella similis Clinical Isolate CBS 149759 Open
View article: PK-PD Evaluation of Inhaled Microparticles loaded with Ciprofloxacin-Copper complex in a Rat Model of Chronic Pseudomonas aeruginosa Lung Infection.
PK-PD Evaluation of Inhaled Microparticles loaded with Ciprofloxacin-Copper complex in a Rat Model of Chronic Pseudomonas aeruginosa Lung Infection. Open
View article: Targeting lung macrophages for fungal and parasitic pulmonary infections with innovative amphotericin B dry powder inhalers
Targeting lung macrophages for fungal and parasitic pulmonary infections with innovative amphotericin B dry powder inhalers Open
The incidence of fungal pulmonary infections is known to be on the increase, and yet there is an alarming gap in terms of marketed antifungal therapies that are available for pulmonary administration. Amphotericin B (AmB) is a highly effic…
View article: The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder Open
Autism Spectrum Disorder (ASD) is a progressive neurodevelopmental disorder mainly characterized by deficits in social communication and stereotyped behaviors and interests. Here, we aimed to investigate the state of several key players in…
View article: A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients
A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients Open
Understanding antibiotic concentration-time profiles in the central nervous system (CNS) is crucial to treat severe life-threatening CNS infections, such as nosocomial ventriculitis or meningitis. Yet CNS distribution is likely to be alter…
View article: Population pharmacokinetic/pharmacodynamic study suggests continuous infusion of ceftaroline daily dose in ventilated critical care patients with early-onset pneumonia and augmented renal clearance
Population pharmacokinetic/pharmacodynamic study suggests continuous infusion of ceftaroline daily dose in ventilated critical care patients with early-onset pneumonia and augmented renal clearance Open
Objectives Ceftaroline could be suitable to treat early-onset ventilator-associated pneumonia (VAP) because of its antibacterial spectrum. However, augmented renal clearance (ARC) is frequent in ICU patients and may affect ceftaroline phar…
View article: PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo
PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo Open
The reduction in antimicrobial activity at high bacterial counts is a microbiological phenomenon known as the inoculum effect (IE). In a previous in vitro study, a significant IE was observed for polymyxin B (PMB) against a clinical isolat…
View article: Inhaled Antifungal Agents for Treatment and Prophylaxis of Bronchopulmonary Invasive Mold Infections
Inhaled Antifungal Agents for Treatment and Prophylaxis of Bronchopulmonary Invasive Mold Infections Open
Pulmonary mold infections are life-threatening diseases with high morbi-mortalities. Treatment is based on systemic antifungal agents belonging to the families of polyenes (amphotericin B) and triazoles. Despite this treatment, mortality r…
View article: A physiologically based pharmacokinetic (PBPK) model exploring the blood-milk barrier in lactating species - A case study with oxytetracycline administered to dairy cows and goats
A physiologically based pharmacokinetic (PBPK) model exploring the blood-milk barrier in lactating species - A case study with oxytetracycline administered to dairy cows and goats Open
Antibiotic excretion into milk depends on several factors such as the compound's physicochemical properties, the animal physiology, and the milk composition. The objective of this study was to develop a physiologically based pharmacokineti…
View article: Improved In Vitro Anti-Mucorales Activity and Cytotoxicity of Amphotericin B with a Pegylated Surfactant
Improved In Vitro Anti-Mucorales Activity and Cytotoxicity of Amphotericin B with a Pegylated Surfactant Open
The aim of this study was to evaluate the effect of the combination of amphotericin B (AmB) and various non-ionic surfactants on the anti-Mucorales activity of AmB, the toxicity of the combination on eukaryotic cells and the modification o…
View article: Lipid Nanoparticles Loaded with Farnesol or Geraniol to Enhance the Susceptibility of E. coli MCR-1 to Colistin
Lipid Nanoparticles Loaded with Farnesol or Geraniol to Enhance the Susceptibility of E. coli MCR-1 to Colistin Open
Resistance to colistin, one of the antibiotics of last resort against multidrug-resistant Gram-negative bacteria, is increasingly reported. Notably, MCR plasmids discovered in 2015 have now been reported worldwide in humans. To keep this a…