Explanipedia

FISIOTERAPIA E DERMATO FUNCIONAL: QUAL A CORRELAÇÃO? Open

A. Sousa, Andreia Luzia Ribeiro de Pádua, Danilo Silveira Fernandes, Joana Santos, Sandro L. Pereira , et al. · 2025

Esse artigo buscou avaliar o papel da fisioterapia dermatofuncional na promoção da saúde estética e funcional dos pacientes, por meio de uma revisão de literatura narrativa e descritiva, baseada em artigos científicos das bases de dados BV…

Exploring environmental modifiers of LRRK2-associated Parkinson’s disease penetrance: An exposomics and metagenomics pilot study on household dust Open

Begoña Talavera Andújar, Sandro L. Pereira, Susheel Bhanu Busi, Tatiana Usnich, Max Borsche , et al. · 2024

Pathogenic variants in the Leucine-rich repeat kinase 2 (LRRK2) gene are a primary monogenic cause of Parkinson's disease (PD). However, the likelihood of developing PD with inherited LRRK2 pathogenic variants differs (a phenomenon known a…

Exploring Environmental Modifiers of LRRK2-Associated Parkinson’s Disease Penetrance through Exposomics and Metagenomics of Household Dust Open

Begoña Talavera Andújar, Sandro L. Pereira, Susheel Bhanu Busi, Tatiana Usnich, Max Borsche , et al. · 2024

Pathogenic variants in the Leucine-rich repeat kinase 2 (LRRK2) gene are a primary monogenic cause of Parkinson’s disease (PD). However, the likelihood of developing PD with inherited LRRK2 pathogenic variants differs (a phenomenon known a…

Metformin impacts the differentiation of mouse bone marrow cells into macrophages affecting tumour immunity Open

Andrea Scafidi, Frida Lind‐Holm Mogensen, Eleonora Campus, Alexandros Pailas, Katrin Neumann , et al. · 2024

PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation Open

Frida Lind‐Holm Mogensen, Carole Sousa, Corrado Ameli, Katja Badanjak, Sandro L. Pereira , et al. · 2024

Background Specific microglia responses are thought to contribute to the development and progression of neurodegenerative diseases, including Parkinson’s disease (PD). However, the phenotypic acquisition of microglial cells and their role …

Metformin Impacts the Differentiation of Bone Marrow Cells into Macrophages Affecting Tumour Immunity Open

Andrea Scafidi, Frida Lind‐Holm Mogensen, Eleonora Campus, Alexandros Pailas, Katrin Neumann , et al. · 2024

Exploring Environmental Modifiers of Lrrk2-Associated Parkinson's Disease Penetrance Through Exposomics and Metagenomics of Household Dust Open

Begoña Talavera Andújar, Sandro L. Pereira, Susheel Bhanu Busi, Tatiana Usnich, Max Borsche , et al. · 2024

Comparison of two protocols for the generation of iPSC-derived human astrocytes Open

Patrycja Mulica, Carmen Venegas, Zied Landoulsi, Katja Badanjak, Sylvie Delcambre , et al. · 2023

Background Astrocytes have recently gained attention as key contributors to the pathogenesis of neurodegenerative disorders including Parkinson’s disease. To investigate human astrocytes in vitro, numerous differentiation protocols have be…

Parkin Deficiency Impairs Mitochondrial <span>DNA</span> Dynamics and Propagates Inflammation Open

Kobi Wasner, Semra Smajić, Jenny Ghelfi, Sylvie Delcambre, Cesar A. Prada‐Medina , et al. · 2022

Background Mutations in the E3 ubiquitin ligase parkin cause autosomal recessive Parkinson's disease (PD). Together with PTEN‐induced kinase 1 ( PINK1 ), parkin regulates the clearance of dysfunctional mitochondria. New mitochondria are ge…

Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state Open

Semra Smajić, Cesar A. Prada‐Medina, Zied Landoulsi, Jenny Ghelfi, Sylvie Delcambre , et al. · 2021

Idiopathic Parkinson’s disease is characterized by a progressive loss of dopaminergic neurons, but the exact disease aetiology remains largely unknown. To date, Parkinson’s disease research has mainly focused on nigral dopaminergic neurons…

iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson’s Disease Open

Katja Badanjak, Patrycja Mulica, Semra Smajić, Sylvie Delcambre, Léon-Charles Tranchevent , et al. · 2021

Parkinson’s disease (PD) is a neurodegenerative disease with unknown cause in the majority of patients, who are therefore considered “idiopathic” (IPD). PD predominantly affects dopaminergic neurons in the substantia nigra pars compacta (S…

Nanopore Single-Molecule Sequencing for Mitochondrial DNA Methylation Analysis: Investigating Parkin-Associated Parkinsonism as a Proof of Concept Open

Theresa Lüth, Kobi Wasner, Christine Klein, Susen Schaake, Ronnie Tse , et al. · 2021

Objective: To establish a workflow for mitochondrial DNA (mtDNA) CpG methylation using Nanopore whole-genome sequencing and perform first pilot experiments on affected Parkin biallelic mutation carriers (Parkin-PD) and healthy controls. Ba…

Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective Open

Patrycja Mulica, Anne Grünewald, Sandro L. Pereira · 2021

Converging evidence made clear that declining brain energetics contribute to aging and are implicated in the initiation and progression of neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Indeed, both pathologies in…

Analysis of mitochondrial genome methylation using Nanopore single-molecule sequencing Open

Theresa Lüth, Christine Klein, Susen Schaake, Ronnie Tse, Sandro L. Pereira , et al. · 2021

The level and the biological significance of mitochondrial DNA (mtDNA) methylation in human cells is a controversial topic. Using long-read third-generation sequencing technology, mtDNA methylation can be detected directly from the sequenc…

Mitochondria and Parkinson’s Disease: Clinical, Molecular, and Translational Aspects Open

Max Borsche, Sandro L. Pereira, Christine Klein, Anne Grünewald · 2020

Mitochondrial dysfunction represents a well-established player in the pathogenesis of both monogenic and idiopathic Parkinson’s disease (PD). Initially originating from the observation that mitochondrial toxins cause PD, findings from gene…

Mitochondrial Mechanisms of LRRK2 G2019S Penetrance Open

Sylvie Delcambre, Jenny Ghelfi, Nassima Ouzren, Léa Grandmougin, Catherine Delbrouck , et al. · 2020

Several mutations in leucine-rich repeat kinase-2 (LRRK2) have been associated with Parkinson's disease (PD). The most common substitution, G2019S, interferes with LRRK2 kinase activity, which is regulated by autophosphorylation. Yet, the …

Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism Open

Max Borsche, Inke R. König, Sylvie Delcambre, Simona Petrucci, Alexander Balck , et al. · 2020

There is increasing evidence for a role of inflammation in Parkinson’s disease. Recent research in murine models suggests that parkin and PINK1 deficiency leads to impaired mitophagy, which causes the release of mitochondrial DNA (mtDNA), …

Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software Open

Tânia Perestrelo, Weitong Chen, Marcelo Correia, Christopher Le, Sandro L. Pereira , et al. · 2018

(Stem Cell Reports 9, 697–709; August 8, 2017) In the originally published version of this Resource, an error appeared in Equation 4 in the Experimental Procedures. The error does not affect the conclusions of the paper; all of the calcula…

Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software Open

Tânia Perestrelo, Weitong Chen, Marcelo Correia, Christopher Le, Sandro L. Pereira , et al. · 2017

Image-based assays, such as alkaline phosphatase staining or immunocytochemistry for pluripotent markers, are common methods used in the stem cell field to assess pluripotency. Although an increased number of image-analysis approaches have…

Data on the potential impact of food supplements on the growth of mouse embryonic stem cells Open

Marcelo Correia, Maria Inês Sousa, Ana Sofia Rodrigues, Tânia Perestrelo, Sandro L. Pereira , et al. · 2016

Antimycin A disturbs mESC neuronal differentiation. Open

Sandro L. Pereira, Mário Grãos, Ana Sofia Rodrigues, Sandra I. Anjo, Rui A. Carvalho , et al. · 2015

mESCs differentiated for 14 days into dopaminergic neurons using a PA6-based system were treated with AA since day 2. Representative phase contrast microscopy images were obtained at different time-points of the process (days 7, 10 and 14)…

Differentiate or Die: 3-Bromopyruvate and Pluripotency in Mouse Embryonic Stem Cells Open

Ana Sofia Rodrigues, Sandro L. Pereira, Marcelo Correia, Andreia Gomes, Tânia Perestrelo , et al. · 2015

Treatment of mESCs with 3BrP triggered a metabolic switch and loss of pluripotency, even in the presence of LIF. Interestingly, the positive control for differentiation allowed for a distinction between 3BrP effects and changes associated …

Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency Open

Ana Sofia Rodrigues, Marcelo Correia, Andreia Gomes, Sandro L. Pereira, Tânia Perestrelo , et al. · 2015

DCA negatively affects ESC pluripotency by changing cell metabolism and elements related to the PDH cycle, suggesting that PDHK could function as a possible metabolic gatekeeper in ESC, and may be a good target to modulate metabolism and d…

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