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View article: Alpha-1 antitrypsin reduces inflammation and vasculopathy in mice with oxygen-induced retinopathy
Alpha-1 antitrypsin reduces inflammation and vasculopathy in mice with oxygen-induced retinopathy Open
Background Damage to the retinal vasculature is a major cause of vision loss and is influenced by a pro-inflammatory environment within retinal tissue. Alpha-1 antitrypsin (AAT) is a potent inhibitor of serine proteases and has anti-inflam…
View article: Therapeutic ISCOMATRIX™ adjuvant vaccine elicits effective anti-tumor immunity in the TRAMP-C1 mouse model of prostate cancer
Therapeutic ISCOMATRIX™ adjuvant vaccine elicits effective anti-tumor immunity in the TRAMP-C1 mouse model of prostate cancer Open
View article: Cross-presentation of cutaneous melanoma antigen by migratory XCR1<sup>+</sup>CD103<sup>−</sup>and XCR1<sup>+</sup>CD103<sup>+</sup>dendritic cells
Cross-presentation of cutaneous melanoma antigen by migratory XCR1<sup>+</sup>CD103<sup>−</sup>and XCR1<sup>+</sup>CD103<sup>+</sup>dendritic cells Open
The question of which dendritic cells (DCs) cross-present peripheral tumor antigens remains unanswered. We assessed the ability of multiple skin-derived and lymphoid resident DCs to perform this function in a novel orthotopic murine melano…