Sandro Satta
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View article: Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolites
Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolites Open
Exercise promotes pulsatile shear stress in the arterial circulation and ameliorates cardiometabolic diseases. However, exercise-mediated metabolic transducers for vascular protection remain under-investigated. Untargeted metabolomic analy…
View article: α-Glucosidase inhibition by green, white and oolong teas: <i>in vitro</i> activity and computational studies
α-Glucosidase inhibition by green, white and oolong teas: <i>in vitro</i> activity and computational studies Open
Natural α-glucosidase inhibitors from plant-based foods such as catechins offer an attractive strategy for their potential anti-diabetic effects. In this study, infusions of three different tea types (green, white, and oolong) were investi…
View article: Microfluidic Organ-Chips and Stem Cell Models in the Fight Against COVID-19
Microfluidic Organ-Chips and Stem Cell Models in the Fight Against COVID-19 Open
SARS-CoV-2, the virus underlying COVID-19, has now been recognized to cause multiorgan disease with a systemic effect on the host. To effectively combat SARS-CoV-2 and the subsequent development of COVID-19, it is critical to detect, monit…
View article: Exercise Mitigates Flow Recirculation and Activates Mechanosensitive Transcriptome to Uncover Endothelial SCD1-Catalyzed Anti-Inflammatory Metabolites
Exercise Mitigates Flow Recirculation and Activates Mechanosensitive Transcriptome to Uncover Endothelial SCD1-Catalyzed Anti-Inflammatory Metabolites Open
Exercise modulates vascular plasticity in multiple organ systems; however, the metabolomic transducers underlying exercise and vascular protection in the disturbed flow-prone vasculature remain under-investigated. We simulated exercise-aug…
View article: Mitoquinone Mesylate and Mitochondrial DNA in End Organs in Humanized Mouse Model of Chronic Treated Human Immunodeficiency Virus Infection
Mitoquinone Mesylate and Mitochondrial DNA in End Organs in Humanized Mouse Model of Chronic Treated Human Immunodeficiency Virus Infection Open
No treatment exists for mitochondrial dysfunction, a contributor to end-organ disease in human immunodeficiency virus (HIV). The mitochondrial antioxidant mitoquinone mesylate (MitoQ) attenuates mitochondrial dysfunction in preclinical mou…
View article: A Nrf2-OSGIN1&2-HSP70 axis mediates cigarette smoke-induced endothelial detachment: implications for plaque erosion
A Nrf2-OSGIN1&2-HSP70 axis mediates cigarette smoke-induced endothelial detachment: implications for plaque erosion Open
Aims Endothelial erosion of plaques is responsible for ∼30% of acute coronary syndromes (ACS). Smoking is a risk factor for plaque erosion, which most frequently occurs on the upstream surface of plaques where the endothelium experiences e…
View article: The role of oxidative stress in the pathogenesis of infections with coronaviruses
The role of oxidative stress in the pathogenesis of infections with coronaviruses Open
Coronaviruses can cause serious respiratory tract infections and may also impact other end organs such as the central nervous system, the lung and the heart. The coronavirus disease 2019 (COVID-19) has had a devastating impact on humanity.…
View article: Mitoquinone mesylate attenuates brain inflammation in humanized mouse model of chronic HIV infection
Mitoquinone mesylate attenuates brain inflammation in humanized mouse model of chronic HIV infection Open
Satta, Sandro; Hugo, Cristelle; Sharma, Madhav; Rezek, Valerie; Kossyvakis, Athanassios; Roy, Shubhendu Sen; Kitchen, Scott; Kelesidis, Theodoros Author Information
View article: Engineering organ-on-a-chip systems to model viral infections
Engineering organ-on-a-chip systems to model viral infections Open
Infectious diseases remain a public healthcare concern worldwide. Amidst the pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 infection, increasing resources have been diverted to i…
View article: Mitoquinone mesylate targets SARS-CoV-2 infection in preclinical models
Mitoquinone mesylate targets SARS-CoV-2 infection in preclinical models Open
Summary To date, there is no effective oral antiviral against SARS-CoV-2 that is also anti-inflammatory. Herein, we show that the mitochondrial antioxidant mitoquinone/mitoquinol mesylate (Mito-MES), a dietary supplement, has potent antivi…
View article: Computational simulations of the 4D micro-circulatory network in zebrafish tail amputation and regeneration
Computational simulations of the 4D micro-circulatory network in zebrafish tail amputation and regeneration Open
Wall shear stress (WSS) contributes to the mechanotransduction underlying microvascular development and regeneration. Using computational fluid dynamics, we elucidated the interplay between WSS and vascular remodelling in a zebrafish model…
View article: An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages
An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages Open
Rationale: Macrophages are the frontline immune cells in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Angiotensin-converting enzyme 2 (ACE2) serves as the binding receptor to SARS-CoV-2 Spike glycopro…
View article: Engineering viral genomics and nano-liposomes in microfluidic platforms for patient-specific analysis of SARS-CoV-2 variants
Engineering viral genomics and nano-liposomes in microfluidic platforms for patient-specific analysis of SARS-CoV-2 variants Open
New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are continuing to spread globally, contributing to the persistence of the COVID-19 pandemic. Increasing resources have been focused on developing vaccines and the…
View article: Rapid Detection and Inhibition of SARS‐CoV‐2‐Spike Mutation‐Mediated Microthrombosis
Rapid Detection and Inhibition of SARS‐CoV‐2‐Spike Mutation‐Mediated Microthrombosis Open
Activation of endothelial cells following severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is thought to be the primary driver for the increasingly recognized thrombotic complications in coronavirus disease 2019 patie…
View article: A hybrid of light-field and light-sheet imaging to study myocardial function and intracardiac blood flow during zebrafish development
A hybrid of light-field and light-sheet imaging to study myocardial function and intracardiac blood flow during zebrafish development Open
Biomechanical forces intimately contribute to cardiac morphogenesis. However, volumetric imaging to investigate the cardiac mechanics with high temporal and spatial resolution remains an imaging challenge. We hereby integrated light-field …
View article: Computational Simulations of the 4-D Micro-Circulatory Network in Zebrafish Tail Amputation and Regeneration
Computational Simulations of the 4-D Micro-Circulatory Network in Zebrafish Tail Amputation and Regeneration Open
Wall shear stress (WSS) in the micro-vasculature contributes to biomechanical cues that regulate mechanotransduction underlying vascular development, regeneration, and homeostasis. We hereby elucidate the interplay between hemodynamic shea…
View article: Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection
Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection Open
Background and Purpose: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is associated with an increased rate of cerebrovascular events including ischemic stroke and intracerebral hemorrhage. The mechanisms underlying…
View article: Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture
Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture Open
Photoaffinity labeling (PAL) is one of the upcoming and powerful tools in the field of molecular recognition. It includes the determination of dynamic parameters, such as the identification and localization of the target protein and the si…
View article: 143 A pivotal role for NRF2 in endothelial detachment–implications for endothelial erosion of stenotic plaques
143 A pivotal role for NRF2 in endothelial detachment–implications for endothelial erosion of stenotic plaques Open
Introduction Endothelial erosion of atherosclerotic plaques and resulting thrombosis causes approximately 30% of acute coronary syndromes (ACS). Plaque erosion is most frequently observed in smokers, which induces endothelial dysfunction, …
View article: A pivotal role for Nrf2 in endothelial detachment- implications for endothelial erosion of stenotic plaques
A pivotal role for Nrf2 in endothelial detachment- implications for endothelial erosion of stenotic plaques Open
Endothelial erosion of atherosclerotic plaques and resulting thrombosis causes approximately 30% of acute coronary syndromes (ACS). As changes in the haemodynamic environment strongly influence endothelial function and contribute to plaque…
View article: The Role of Nrf2 in Cardiovascular Function and Disease
The Role of Nrf2 in Cardiovascular Function and Disease Open
Free radicals, reactive oxygen/nitrogen species (ROS/RNS), hydrogen sulphide, and hydrogen peroxide play an important role in both intracellular and intercellular signaling; however, their production and quenching need to be closely regula…