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View article: Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels
Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels Open
Acid-sensing ion channels have important functions in physiology and pathology, but the molecular composition of acid-activated chloride channels had remained unclear. We now used a genome-wide siRNA screen to molecularly identify the wide…
View article: Identification of TMEM206 proteins as pore of ASOR acid-sensitive chloride channels
Identification of TMEM206 proteins as pore of ASOR acid-sensitive chloride channels Open
Acid-sensing ion channels have important functions in physiology and pathology, but the molecular composition of acid-activated anion channels had remained unclear. We now used a genome-wide siRNA screen to molecularly identify the widely …
View article: Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels
Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels Open
TREK/TRAAK channels are polymodal K+ channels that convert very diverse stimuli, including bioactive lipids, mechanical stretch and temperature, into electrical signals. The nature of the structural changes that regulate their activity rem…
View article: Mixing and matching TREK/TRAAK subunits generate heterodimeric K <sub>2P</sub> channels with unique properties
Mixing and matching TREK/TRAAK subunits generate heterodimeric K <sub>2P</sub> channels with unique properties Open
Significance Nearly 350 human genes encode ion channels. Posttranscriptional (alternative splicing, editing, and alternative translation initiation) and posttranslational mechanisms (glycosylation, phosphorylation) further increase diversi…