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View article: The association of genetic variants of type 2 diabetes with kidney function
The association of genetic variants of type 2 diabetes with kidney function Open
Type 2 diabetes is highly prevalent and is the major cause of progressive chronic kidney disease in American Indians. Genome wide association studies identified several loci associated with diabetes but their impact on susceptibility to di…
View article: The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study
The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study Open
Chronic kidney disease (CKD) is an important public health problem in American Indian populations. Recent research has identified associations of polymorphisms in the myosin heavy chain type II isoform A (MYH9) gene with hypertensive CKD i…
View article: Social- and Behavioral-Specific Genetic Effects on Blood Pressure Traits: The Strong Heart Family Study
Social- and Behavioral-Specific Genetic Effects on Blood Pressure Traits: The Strong Heart Family Study Open
Population studies have demonstrated an important role of social, behavioral, and environmental factors in blood pressure levels. Accounting for the genetic interaction of these factors may help to identify common blood pressure susceptibi…
View article: Genome-wide Linkage Analysis of Pulse Pressure in American Indians: The Strong Heart Study
Genome-wide Linkage Analysis of Pulse Pressure in American Indians: The Strong Heart Study Open
Pulse pressure, a measure of central arterial stiffness and a predictor of cardiovascular mortality, has known genetic components.
View article: Linkage Study of Fibrinogen Levels: The Strong Heart Family Study
Linkage Study of Fibrinogen Levels: The Strong Heart Family Study Open
Background The pathogenesis of atherosclerosis involves both hemostatic and inflammatory mechanisms. Fibrinogen is associated with both risk of thrombosis and inflammation. A recent meta-analysis showed that risk of coronary heart disease …