Sandy R. Shultz
YOU?
Author Swipe
View article: Standardization of preclinical methodologies for discovery and validation of circulating microRNA biomarkers for post-traumatic epileptogenesis – Lessons learned from the EpiBioS4Rx Project 1
Standardization of preclinical methodologies for discovery and validation of circulating microRNA biomarkers for post-traumatic epileptogenesis – Lessons learned from the EpiBioS4Rx Project 1 Open
Our study demonstrates that conducting a successful plasma miRNA biomarker analysis requires procedural harmonization between laboratories, protocol standardization, inclusion and analysis of quality controls, training of researchers, and …
View article: Advocates, Academics, Survivors and Clinicians to END Intimate Partner Violence (ASCEND-IPV) initiative: a prospective observational case–control study protocol to identify plasma biomarkers of intimate partner violence (IPV)-caused brain injury (BI)
Advocates, Academics, Survivors and Clinicians to END Intimate Partner Violence (ASCEND-IPV) initiative: a prospective observational case–control study protocol to identify plasma biomarkers of intimate partner violence (IPV)-caused brain injury (BI) Open
Introduction Although as many as 92% of survivors of physical intimate partner violence (IPV) report impacts to the head and/or non-fatal strangulation (NFS) that raise clinical suspicion of brain injury (BI), there are no evidence-based m…
View article: MedNet-PVS: A MedNeXt-Based Deep Learning Model for Automated Segmentation of Perivascular Spaces
MedNet-PVS: A MedNeXt-Based Deep Learning Model for Automated Segmentation of Perivascular Spaces Open
Enlarged perivascular spaces (PVS) are increasingly recognized as biomarkers of cerebral small vessel disease, Alzheimer's disease, stroke, and aging-related neurodegeneration. However, manual segmentation of PVS is time-consuming and subj…
View article: The normative modelling framework for traumatic brain injury
The normative modelling framework for traumatic brain injury Open
This review examines the principles, applications and methodological foundations of normative modelling, emphasizing its potential to assist in mitigating longstanding challenges in traumatic brain injury (TBI) research and management. TBI…
View article: The chronic aftermath of recurrent intimate partner violence-related brain injuries: Insights from rat models of traumatic brain injury and non-fatal strangulation
The chronic aftermath of recurrent intimate partner violence-related brain injuries: Insights from rat models of traumatic brain injury and non-fatal strangulation Open
Intimate partner violence (IPV) is a serious global health concern that primarily affects women. Traumatic brain injury (TBI; e.g., concussion) and non-fatal strangulation (NFS) are common forms of IPV-related brain injuries which often oc…
View article: 51 (5B) Instrumented mouthguard-measured head kinematics and associations with head injury assessment outcomes in elite men’s and women’s Australian football
51 (5B) Instrumented mouthguard-measured head kinematics and associations with head injury assessment outcomes in elite men’s and women’s Australian football Open
View article: Can the gut-brain axis provide insight into psilocybin's therapeutic value in reducing stress?
Can the gut-brain axis provide insight into psilocybin's therapeutic value in reducing stress? Open
View article: 46 (5A) Exploring the incidence, magnitude and causes of head acceleration events measured by instrumented mouthguards in elite men’s and women’s Australian football
46 (5A) Exploring the incidence, magnitude and causes of head acceleration events measured by instrumented mouthguards in elite men’s and women’s Australian football Open
View article: Maternal oxytocin administration mitigates nociceptive, social, and epigenetic impairments in adolescent offspring exposed to perinatal trauma
Maternal oxytocin administration mitigates nociceptive, social, and epigenetic impairments in adolescent offspring exposed to perinatal trauma Open
View article: A pre-existing chronic Toxoplasma gondii infection promotes epileptogenesis and neuropathology in a mouse model of mesial temporal lobe epilepsy
A pre-existing chronic Toxoplasma gondii infection promotes epileptogenesis and neuropathology in a mouse model of mesial temporal lobe epilepsy Open
These findings demonstrate that a chronic T. gondii infection can result in epilepsy, and that a pre-existing T. gondii infection exacerbates epileptogenesis following a brain insult, in mice.
View article: Investigating the role of the brain-derived neurotrophic factor Val66Met polymorphism in repetitive mild traumatic brain injury outcomes in rats
Investigating the role of the brain-derived neurotrophic factor Val66Met polymorphism in repetitive mild traumatic brain injury outcomes in rats Open
View article: Acute diffuse axonal injury following repeated mild traumatic brain injury in juvenile rats
Acute diffuse axonal injury following repeated mild traumatic brain injury in juvenile rats Open
Diffuse axonal injury is a hallmark feature of all severities of traumatic brain injury (TBI) yet, in preclinical mild (m)TBI research no studies have yet investigated axonal damage with silver stain immunohistochemistry in female animals.…
View article: Bundle-specific tractography approach for identifying white matter microstructural changes following traumatic brain injury in rats: An EpiBioS4Rx study
Bundle-specific tractography approach for identifying white matter microstructural changes following traumatic brain injury in rats: An EpiBioS4Rx study Open
Traumatic brain injury (TBI) presents a major global health concern, characterized by a variety of negative long-term neurological outcomes. Current diagnostic tools lack the sensitivity to fully capture the complex pathophysiology of TBI …
View article: Plasma <scp>microRNAs</scp> as prognostic biomarkers for development of severe epilepsy after experimental traumatic brain injury— <scp>EpiBioS4Rx</scp> Project 1 study
Plasma <span>microRNAs</span> as prognostic biomarkers for development of severe epilepsy after experimental traumatic brain injury— <span>EpiBioS4Rx</span> Project 1 study Open
Objective To test a hypothesis that acutely regulated plasma microRNAs (miRNAs) can serve as prognostic biomarkers for the development of post‐traumatic epilepsy (PTE). Methods Adult male Sprague–Dawley rats ( n = 245) were randomized to l…
View article: Associations Between Instrumented Mouthguard-Measured Head Acceleration Events and Post-Match Biomarkers of Astroglial and Axonal Injury in Male Amateur Australian Football Players
Associations Between Instrumented Mouthguard-Measured Head Acceleration Events and Post-Match Biomarkers of Astroglial and Axonal Injury in Male Amateur Australian Football Players Open
View article: Exploiting blood-based biomarkers to align preclinical models with human traumatic brain injury
Exploiting blood-based biomarkers to align preclinical models with human traumatic brain injury Open
Rodent models are important research tools for studying the pathophysiology of traumatic brain injury (TBI) and developing new therapeutic interventions for this devastating neurological disorder. However, the failure rate for the translat…
View article: Pharmacokinetics and brain uptake of sodium selenate and selenium in naïve rats and a lateral fluid percussion injury rat model
Pharmacokinetics and brain uptake of sodium selenate and selenium in naïve rats and a lateral fluid percussion injury rat model Open
Post‐traumatic epilepsy (PTE) is a life‐long complication of traumatic brain injury (TBI). The development of PTE is associated with neurological morbidity and increases the risk of mortality. An aim of EpiBioS4Rx ( Epilepsy Bioinformatics…
View article: Detecting a hidden pandemic: The current state and future direction of screening and assessment tools for intimate partner violence-related brain injury
Detecting a hidden pandemic: The current state and future direction of screening and assessment tools for intimate partner violence-related brain injury Open
View article: Pathophysiology, blood biomarkers, and functional deficits after intimate partner violence-related brain injury: Insights from emergency department patients and a new rat model
Pathophysiology, blood biomarkers, and functional deficits after intimate partner violence-related brain injury: Insights from emergency department patients and a new rat model Open
Intimate partner violence is a serious, but underappreciated, issue that predominantly affects women and often results in concussion (i.e., mild traumatic brain injury). However, concussion in intimate partner violence is unique because it…
View article: The beneficial effects of modafinil administration on repeat mild traumatic brain injury (RmTBI) pathology in adolescent male rats are not dependent upon the orexinergic system
The beneficial effects of modafinil administration on repeat mild traumatic brain injury (RmTBI) pathology in adolescent male rats are not dependent upon the orexinergic system Open
The sleep-wake cycle plays an influential role in the development and progression of repeat mild traumatic brain injury (RmTBI)-related pathology. Therefore, we first aimed to manipulate the sleep-wake cycle post-RmTBI using modafinil, a w…
View article: Plasma biomarkers in chronic single moderate–severe traumatic brain injury
Plasma biomarkers in chronic single moderate–severe traumatic brain injury Open
Blood biomarkers are an emerging diagnostic and prognostic tool that reflect a range of neuropathological processes following traumatic brain injury (TBI). Their effectiveness in identifying long-term neuropathological processes after TBI …
View article: Research priorities for diagnosis, prognosis, and rehabilitation following concussion: results from a national survey of Australian health professionals
Research priorities for diagnosis, prognosis, and rehabilitation following concussion: results from a national survey of Australian health professionals Open
The research priorities identified can guide research efforts to improve the assessment, management, and rehabilitation of individuals with concussion/mTBI in Australia.
View article: Next-Day Serum Glial Fibrillary Acidic Protein Levels to Aid Diagnosis of Sport-Related Concussion
Next-Day Serum Glial Fibrillary Acidic Protein Levels to Aid Diagnosis of Sport-Related Concussion Open
The diagnostic utility of blood glial fibrillary acidic protein (GFAP) in sport-related concussion (SRC) is unclear. This study measured serum GFAP at either 16-24 hours (h), 24-32h, or 36-52h post-SRC in 156 Australian football players an…
View article: Biomarkers of Neurobiologic Recovery in Adults With Sport-Related Concussion
Biomarkers of Neurobiologic Recovery in Adults With Sport-Related Concussion Open
Importance Sport-related concussion (SRC), a form of mild traumatic brain injury, is a prevalent occurrence in collision sports. There are no well-established approaches for tracking neurobiologic recovery after SRC. Objective To examine t…
View article: Dynamics of synaptic damage in severe traumatic brain injury revealed by cerebrospinal fluid SNAP-25 and VILIP-1
Dynamics of synaptic damage in severe traumatic brain injury revealed by cerebrospinal fluid SNAP-25 and VILIP-1 Open
Background Biomarkers of neuronal, glial cells and inflammation in traumatic brain injury (TBI) are available but they do not specifically reflect the damage to synapses, which represent the bulk volume of the brain. Experimental models ha…
View article: ComBating inter‐site differences in field strength: harmonizing preclinical traumatic brain injury MRI data
ComBating inter‐site differences in field strength: harmonizing preclinical traumatic brain injury MRI data Open
Integrating datasets from multiple sites and scanners can increase statistical power for neuroimaging studies but can also introduce significant inter‐site confounds. We evaluated the effectiveness of ComBat, an empirical Bayes approach, t…
View article: Altered grey matter structural covariance in chronic moderate–severe traumatic brain injury
Altered grey matter structural covariance in chronic moderate–severe traumatic brain injury Open
View article: A pre-existing Toxoplasma gondii infection exacerbates the pathophysiological response and extent of brain damage after traumatic brain injury in mice
A pre-existing Toxoplasma gondii infection exacerbates the pathophysiological response and extent of brain damage after traumatic brain injury in mice Open
View article: Investigating the Association Between Extended Participation in Collision Sports and Fluid Biomarkers Among Masters Athletes
Investigating the Association Between Extended Participation in Collision Sports and Fluid Biomarkers Among Masters Athletes Open
Traumatic brain injuries (TBIs) and concussions are prevalent in collision sports, and there is evidence that levels of exposure to such sports may increase the risk of neurological abnormalities. Elevated levels of fluid-based biomarkers …
View article: Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter <scp>EpiBioS4Rx</scp> study project 1
Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter <span>EpiBioS4Rx</span> study project 1 Open
Objective This study was undertaken to assess reproducibility of the epilepsy outcome and phenotype in a lateral fluid percussion model of posttraumatic epilepsy (PTE) across three study sites. Methods A total of 525 adult male Sprague Daw…