Explanipedia

Atrial Fibrillation Recurrence After Left Atrial Appendage Occlusion in Patients Undergoing Ablation Open

Arwa Younis, Devi G. Nair, Luigi Di Biase, Roland Richard Tilz, Walid I. Saliba , et al. · 2025

Among patients undergoing AF ablation, LAAC (concomitant or sequential) does not affect AF ablation outcomes. The stroke/systemic embolism rate was low in all groups. Nevertheless, the trial highlights that stroke and systemic embolism rem…

How Fair Is the Fair Market Value for Cardiac Electrophysiology Physician Reimbursement? Open

Scott J Greenberg, Rohit Mehta, Rahul Chaudhary, Richard Perry, Arash Aryana , et al. · 2025

Comparison of a guidewire with an uninsulated tip versus dedicated radiofrequency wire with discrete electrode for energy-based transseptal puncture: a pre-clinical study Open

Amin Al‐Ahmad, Pamela Horton, Rodney Horton, Christian Balkovec, Rhodaba Ebady , et al. · 2025

Manual protrusion of a wire with a long uninsulated length can be difficult to control in a clinical setting, thus, introducing variability, excess energy, and risk of thermal injury and thrombus formation. A purpose-built electrode and de…

Bipolar radiofrequency ablation for refractory scar-related interatrial septal tachycardias: a multicenter study Open

Piotr Futyma, Łukasz Zarębski, Lohit Garg, Sanghamitra Mohanty, Vincenzo Mirco La Fazia , et al. · 2025

Bi-RFCA is an effective and safe strategy to target scar-related IAS-AT refractory to standard unipolar RFCA.

Sedation vs. general anaesthesia in patients with atrial fibrillation undergoing catheter ablation: a systematic review and meta-analysis Open

Beatriz Araújo, André Rivera, Vanessa Tapioca, Lucas Barbosa, Lucas Caetano , et al. · 2025

Aims Catheter ablation is the standard treatment for symptomatic atrial fibrillation (AF) and can be performed under general anaesthesia (GA) or varying levels of sedation to optimize patient comfort and lesion formation. However, the effe…

Outcomes of pulsed-field ablation with low to zero fluoroscopy utilization for atrial fibrillation treatment Open

Paul C. Zei, David E. Newton, Devi G. Nair, Christopher F. Liu, Mark D. Metzl , et al. · 2025

Contraction sizing versatility of the variable-loop circular catheter for pulmonary vein isolation in atrial fibrillation: A subanalysis from the AdmIRE trial Open

Luigi Di Biase, Vivek Reddy, Marwan Bahu, David E. Newton, Christopher F. Liu , et al. · 2025

Impact of contact force and pulsed field ablation parameters on myocardial lesion formation during pulsed field ablation: A systematic review of pre-clinical studies Open

Jacopo Marazzato, Fengwei Zou, Marco Schiavone, Vincenzo Mirco La Fazia, Giovanni B. Forleo , et al. · 2025

Pulsed field ablation (PFA) is a novel and minimally thermal energy source that exploits the biophysics of irreversible electroporation (IRE) to cause cell death. Differently from radiofrequency ablation (RFA) where adequate catheter-tissu…

Concealed Wenckebach Phenomenon in Left Bundle Branch Associated With Chest Pain Open

Marco Marino, Gianluca Massaro, Vincenzo Carbone, Vincenzo Mirco La Fazia, Giuseppe Stifano , et al. · 2025

The chest pain in painful LBBB syndrome is thought to be related to dyssynchrony in myocardial contraction caused by intermittent depolarization disturbances. Although rare, the Wenckebach phenomenon can complicate conduction in the bundle…

Acute neuromodulation during pulsed field and radiofrequency ablation in patients with paroxysmal atrial fibrillation Open

V La Fazia, Nicola Pierucci, Carola Gianni, Sanghamitra Mohanty, Prem Geeta Torlapati , et al. · 2025

Background Pulsed Field Ablation (PFA) represents a novel, energy approach for pulmonary vein isolation (PVI) in atrial fibrillation (AF) patients, differing from traditional thermal ablation such as radioquency ablation (RFA) for its tiss…

Left atrium size and the risk of atrio-esophageal fistula following thermal ablation in patients with atrial fibrillation Open

Andrea Natale, Sanghamitra Mohanty, Christian‐Hendrik Heeger, Vanessa Schmidt, Helmut Pürerfellner , et al. · 2025

Introduction Prognostic value of the left atrial (LA) size for risk-stratification of atrio-esophageal fistula (AEF) in patients with atrial fibrillation (AF) undergoing thermal ablation procedures, remains unknown. Purpose This study aime…

Extraction of Watchman device using a double transeptal approach Open

V La Fazia, Carola Gianni, Sanghamitra Mohanty, Prem Geeta Torlapati, Weeranun D. Bode , et al. · 2025

Background Left atrial appendage occlusion is a treatment for patients with atrial fibrillation who have a high risk of bleeding and are unable to take oral anticoagulants. The Watchman device is an option and has been shown to be safe and…

Organization of atrial fibrillation during pulsed field ablation Open

V La Fazia, Nicola Pierucci, Paolo Compagnucci, M Schiavone, Carola Gianni , et al. · 2025

Background Pulse Field Ablation (PFA) has been acknowledged as an effective and safe tool for ablation of Atrial Fibrillation (AF). It is known that during AF ablation, the arrhythmia may organize into atrial flutter. The left atrial poste…

Criteria for the establishment of an atrial fibrillation center of excellence and key operational standards Open

T. Jared Bunch, Elliott Antman, John N. Catanzaro, Thomas Deneke, James V. Freeman , et al. · 2025

Catheter Ablation of Atrial Fibrillation in Patients With Psoriasis: A Multicenter Study Open

Paolo Compagnucci, Antonio Russo, Sanghamitra Mohanty, Marco Bergonti, Prem Geeta Torlapati , et al. · 2025

Background Psoriasis is linked to an increased risk of atrial fibrillation (AF). However, data on the electrophysiological substrate and outcomes of AF ablation in patients with psoriasis are lacking. Methods We conducted a retrospective, …

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk Open

Seung Hoan Choi, Sean J. Jurgens, Ling Xiao, Matthew C. Hill, Christopher M. Haggerty , et al. · 2025

Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases Open

Carolina Roselli, Ida Surakka, Morten S. Olesen, Garðar Sveinbjörnsson, Nicholas Marston , et al. · 2025

Early versus late atrial fibrillation recurrence after pulsed field ablation: insights from the admIRE trial Open

Luigi Di Biase, Vivek Y. Reddy, Marwan Bahu, David E. Newton, Christopher F. Liu , et al. · 2025

Aims Studies have shown correlations between early recurrence (ER) and late recurrence (LR) of atrial arrhythmia after ablation with thermal technologies. This admIRE trial (NCT05293639) subanalysis aims to analyse ER vs. LR in patients wi…

Trends in Sudden Cardiac Death Among Adults Aged 25 to 44 Years in the United States: An Analysis of 2 Large US Databases Open

Marco Zuin, Sanghamitra Mohanty, Rahul Aggarwal, Matteo Bertini, Behnood Bikdeli , et al. · 2024

Background Sudden cardiac death (SCD) in early adults aged 25 to 44 years represents an important and unexpected cause of death. We assessed trends in SCD‐related mortality in the United States from 1999 to 2020 among early adults to deter…

Multielectrode catheter-based pulsed electric field vs. cryoballoon for atrial fibrillation ablation: a systematic review and meta-analysis Open

Giampaolo Vetta, Domenico G. Della Rocca, Antonio Parlavecchio, Michele Magnocavallo, Antonio Sorgente , et al. · 2024

Aims Pulsed field ablation (PFA) is an innovative technology recently adopted for the treatment of atrial fibrillation (AF). Preclinical and clinical studies have reported a remarkable safety profile, as a result of its tissue-specific eff…

Comparative effects of different power settings for achieving transmural isolation of the left atrial posterior wall with radiofrequency energy Open

Vincenzo Mirco La Fazia, Nicola Pierucci, Marco Schiavone, Paolo Compagnucci, Sanghamitra Mohanty , et al. · 2024

Reproducibility of semi-quantitative assessment of aortic valve calcification and valve motion on echocardiography: a small-scale study Open

Dikran Raffi Balian, Benjamin Koethe, Sanghamitra Mohanty, Yazan Daaboul, Shant H. Mahrokhian , et al. · 2024

Quest for safe and feasible isolation of superior vena cava by pulsed-field ablation: are we there yet? Open

Moussa Mansour, Sanghamitra Mohanty, Andrea Natale · 2024

Bar diagram shows ablation outcomes in patients undergoing PFA-based SVCI with vs. without ICE guidance. PNS, phrenic nerve stunning; SND, sinus node dysfunction; ICE, intracardiac echocardiography; SVCI, superior vena cava isolation.

Best anticoagulation strategy with and without appendage occlusion for stroke‐prophylaxis in postablation atrial fibrillation patients with cardiac amyloidosis Open

Sanghamitra Mohanty, Prem Geeta Torlapati, Vincenzo Mirco La Fazia, Merve Kurt, Carola Gianni , et al. · 2024

Introduction Both atrial fibrillation (AF) and amyloidosis increase stroke risk. We evaluated the best anticoagulation strategy in AF patients with coexistent amyloidosis. Methods Consecutive AF patients with concomitant amyloidosis were d…

Substrate characterization and outcomes of ventricular tachycardia ablation in amyloid cardiomyopathy: a worldwide study Open

Paolo Compagnucci, Antonio Dello Russo, Alessio Gasperetti, Marco Schiavone, Ojasav Sehrawat , et al. · 2024

Background the electrophysiological substrate underpinning ventricular tachycardia (VT) in cardiac amyloidosis (CA) remains elusive, and outcomes of catheter ablation in this peculiar population are currently unknown. Purpose we sought to …

Prevalence of non pulmonary vein triggers and pulmonary pressure change in atrial fibrillation ablation for cardiac amyloidosis patients Open

V La Fazia, Nicola Pierucci, Carola Gianni, Prem Geeta Torlapati, Sanghamitra Mohanty , et al. · 2024

Background Cardiac amyloidosis (CA) has been associated with an increased risk of atrial arrhythmias and high risk to develop pulmonary hypertension due to infiltration of the amyloid protein in the atrial wall. Though non-PV triggers are …

Arrhythmic mitral valve prolapse with versus without prior mitral valve repair: clinical profiles, electrophysiological substrates, and long-term clinical outcomes Open

Paolo Compagnucci, Michela Casella, M L Narducci, Sanghamitra Mohanty, Laura Cipolletta , et al. · 2024

Background Arrhythmic mitral valve prolapse (AMVP) is characterized by an arrhythmogenic left ventricular substrate, with high prevalence of myocardial scar. Whether patients with prior mitral valve repair for mitral valve prolapse (MVP) a…

Catheter Ablation as First-Line Therapy in Persistent Atrial Fibrillation Open

Michael Barkagan, Anat Milman, Guy Zahavi, Arwa Younis, Bishnu P. Dhakal , et al. · 2024

Direct epicardial validation of posterior wall isolation in persistent atrial fibrillation: pulsed field versus radiofrequency ablation Open

Paolo Compagnucci, F Solimene, Claudio Tondo, Vincenzo Mirco La Fazia, V Schillaci , et al. · 2024

Background Lesion transmurality is an important determinant of durable effectiveness of catheter ablation (CA) for atrial fibrillation (AF). The impact of different energy sources on the achievement of transmural left atrial (LA) ablation …

Impact of catheter ablation on erectile dysfunction in atrial fibrillation patients Open

V La Fazia, Nicola Pierucci, Carola Gianni, Prem Geeta Torlapati, Sanghamitra Mohanty , et al. · 2024

Background Previous studies suggested a consequential link between impaired diastolic function, which could be related to atrial fibrillation (AF), and a heightened susceptibility to erectile dysfunction (ED). No data exists regarding the …

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