Sangkyou Lee
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View article: Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal urothelial differentiation program, contributing to bladder carcinogenesis
Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal urothelial differentiation program, contributing to bladder carcinogenesis Open
View article: Inferring Bladder Cancer Evolution from Mucosal Field Effects by Whole-Organ Spatial Mutational, Proteomic, and Metabolomic Mapping
Inferring Bladder Cancer Evolution from Mucosal Field Effects by Whole-Organ Spatial Mutational, Proteomic, and Metabolomic Mapping Open
Multi-platform mutational, proteomic, and metabolomic spatial mapping was used on the whole-organ scale to identify the molecular evolution of bladder cancer from mucosal field effects. We identified complex proteomic and metabolomic dysre…
View article: The origin of bladder cancer from mucosal field effects
The origin of bladder cancer from mucosal field effects Open
[This corrects the article DOI: 10.1016/j.isci.2022.104551.].
View article: The origin of bladder cancer from mucosal field effects
The origin of bladder cancer from mucosal field effects Open
Whole-organ mapping was used to study molecular changes in the evolution of bladder cancer from field effects. We identified more than 100 dysregulated pathways, involving immunity, differentiation, and transformation, as initiators of car…
View article: The Origin of Bladder Cancer from Mucosal Field Effects
The Origin of Bladder Cancer from Mucosal Field Effects Open
We used whole-organ mapping to study loco-geographic molecular changes in evolution of human bladder cancer from mucosal field effects. The integrative multi-platform analyses based on genome-wide RNA sequencing, methylation, copy number v…
View article: Assessment of Luminal and Basal Phenotypes in Bladder Cancer
Assessment of Luminal and Basal Phenotypes in Bladder Cancer Open
View article: Urothelial-to-Neural Plasticity Drives Progression to Small Cell Bladder Cancer
Urothelial-to-Neural Plasticity Drives Progression to Small Cell Bladder Cancer Open
View article: Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder Cancer
Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder Cancer Open
SUMMARY The sarcomatoid variant of urothelial bladder cancer (SARC) displays a high propensity for distant metastasis and is associated with short survival. We report a comprehensive genomic analysis of 28 cases of SARCs and 84 cases of co…
View article: Detection of Bladder Cancer in Urine Sediments by a Novel Multicolor Fluorescence In Situ Hybridization (Quartet) Test
Detection of Bladder Cancer in Urine Sediments by a Novel Multicolor Fluorescence In Situ Hybridization (Quartet) Test Open
View article: Whole-organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis
Whole-organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis Open
View article: Aurora Kinase A is a Biomarker for Bladder Cancer Detection and Contributes to its Aggressive Behavior
Aurora Kinase A is a Biomarker for Bladder Cancer Detection and Contributes to its Aggressive Behavior Open
View article: Meta-Analysis of the Luminal and Basal Subtypes of Bladder Cancer and the Identification of Signature Immunohistochemical Markers for Clinical Use
Meta-Analysis of the Luminal and Basal Subtypes of Bladder Cancer and the Identification of Signature Immunohistochemical Markers for Clinical Use Open
U.S. National Cancer Institute and National Institute of Health.
View article: Identification of bladder cancer biomarkers by genomic approaches
Identification of bladder cancer biomarkers by genomic approaches Open
Bladder Cancer is one of the most frequent human cancer which develops on two tracks, papillary and non-papillary that correspond to clinically different forms of the disease. Most bladder cancers are chemically induced with tobacco smokin…
View article: Identification of bladder cancer biomarkers by genomic approaches
Identification of bladder cancer biomarkers by genomic approaches Open
Bladder Cancer is one of the most frequent human cancer which develops on two tracks, papillary and non-papillary that correspond to clinically different forms of the disease. Most bladder cancers are chemically induced with tobacco smokin…