Sani Malami
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View article: Ninety Days Repeated Sub-Chronic Toxicity Study of Ethanol Leaf Extract of <i>Laggera Aurita</i> Linn (Asteracea) In Wistar Rats
Ninety Days Repeated Sub-Chronic Toxicity Study of Ethanol Leaf Extract of <i>Laggera Aurita</i> Linn (Asteracea) In Wistar Rats Open
Laggera aurita Linn (Asteraceae) is widely used in Nigeria, Cameroon, Ghana, Senegal, and India for treating malaria, cancer, epilepsy, tuberculosis, and rheumatoid arthritis. This study seeks to establish the safety profile of the ethanol…
View article: ANTICONVULSANT ACTIVITY OF METHANOL LEAF FRACTIONS OF LAGGERA AURITA LINN (ASTERACEAE) IN LABORATORY ANIMALS
ANTICONVULSANT ACTIVITY OF METHANOL LEAF FRACTIONS OF LAGGERA AURITA LINN (ASTERACEAE) IN LABORATORY ANIMALS Open
The Plant Laggera aurita Linn, a widely used medicinal plant in Africa, in the treatment of many medical conditions. This study was conducted to evaluate the anticonvulsant effects of solvents fractions of methanol leaf extract of Laggera …
View article: Preliminary Phytochemical Screening and Quantitative Analysis of Crude Extract of Laggera Aurita Linn (Asteraceae)
Preliminary Phytochemical Screening and Quantitative Analysis of Crude Extract of Laggera Aurita Linn (Asteraceae) Open
Medicinal plants are source of secondary metabolites which are responsible for therapeutic properties that are usually utilized in the treatment and management of several diseases. These metabolites contain bioactive principles and are usu…
View article: Application of hybrid failure mode effect analysis based on fuzzy AHP and fuzzy TOPSIS in quality risk assessment of fixed-dose artemether-lumefantrine tablets
Application of hybrid failure mode effect analysis based on fuzzy AHP and fuzzy TOPSIS in quality risk assessment of fixed-dose artemether-lumefantrine tablets Open
Background A hybrid Failure Mode Effect Analysis (FMEA) based on fuzzy logic and multicriteria decision analytics was applied as a post-marketing surveillance tool for troubleshooting potential quality problems of Artemisinin Combination T…
View article: FIP Seville 2022: Regulatory Sciences and Quality
FIP Seville 2022: Regulatory Sciences and Quality Open
Accepted abstracts under the theme: Regulatory Sciences and Quality (n=16)
View article: Toxicological evaluation of aqueous leaf extract of <i>Terminalia catappa</i> linn (combretaceae) in pregnant rats
Toxicological evaluation of aqueous leaf extract of <i>Terminalia catappa</i> linn (combretaceae) in pregnant rats Open
this study has shown that the aqueous leaf extract of T. catappa is relatively not safe in the pregnant rats. Although it is non-toxic to the fetus, it exhibited tocolytic effect by inhibiting uterine contractions, thus it should be used w…
View article: Ethnomedicinal applications, phytochemistry, and pharmacological properties of Laggera aurita Linn (Asteraceae): A Review
Ethnomedicinal applications, phytochemistry, and pharmacological properties of Laggera aurita Linn (Asteraceae): A Review Open
Background The plant Laggera aurita (Asteraceae) is a commonly utilized medicinal plant growing as a weed in African countries used in the treatment of many diseases. Besides, several phytochemical and pharmacological studies were conducte…
View article: Phytochemistry, ethnomedicinal uses and pharmacological activity of <i>Diodia scandens</i>; a review of current scientific literature
Phytochemistry, ethnomedicinal uses and pharmacological activity of <i>Diodia scandens</i>; a review of current scientific literature Open
Plants are natural sources of readily available phytochemicals which possesses interesting biological activities. The plant Diodia scandens is a creeping and straggling perennial herb commonly dispersed in tropical Africa, tropical Asia an…
View article: Involvement of monoaminergic systems / pathways in the mechanism of action of the antidepressant effect of Leptadenia hastata (Pers.) decne methanol leaf extract
Involvement of monoaminergic systems / pathways in the mechanism of action of the antidepressant effect of Leptadenia hastata (Pers.) decne methanol leaf extract Open
Depression is a mental disorder that is highly prevalent in many parts of the globe and a source of burden to patients and their families. Existing treatments for depression are far from satisfactory because many patients with depression d…
View article: Ethno-botanical survey of medicinal plants used traditionally in the treatment of mental disorders in Kano, Nigeria
Ethno-botanical survey of medicinal plants used traditionally in the treatment of mental disorders in Kano, Nigeria Open
Purpose: To identify medicinal plants used by traditional medicine practitioners to treat mental disorders within Kano metropolis, Nigeria.Methods: A semi-structured questionnaire was administered. It was made up of demographic information…
View article: Co-administration of <i>Zingiber officinale</i> Extract and Sodium Valproate Ameliorates Seizure Severity, Cognitive Deficit, and Neuronal Cell Loss in Pentylenetetrazole-kindled Mice
Co-administration of <i>Zingiber officinale</i> Extract and Sodium Valproate Ameliorates Seizure Severity, Cognitive Deficit, and Neuronal Cell Loss in Pentylenetetrazole-kindled Mice Open
Preparations of Zingiber officinale are used in Nigerian folk medicine to manage colds, pain, arthritis, nausea, and epilepsy. The ameliorative effects of co-administering aqueous Zingiber officinale extract (GE) and sodium valproate (SDV)…
View article: Preclinical efficacy of African medicinal plants used in the treatment of snakebite envenoming: a systematic review protocol
Preclinical efficacy of African medicinal plants used in the treatment of snakebite envenoming: a systematic review protocol Open
Background: Snakebite envenoming (SBE) is a high-priority, neglected, tropical disease that affects millions of people in developing countries annually. The only available standard drug used for the treatment of SBE is antisnake venom (ASV…
View article: In Vivo Antiplasmodial Activity of Detarium microcarpum (Fabaceae) Stem Bark Extract
In Vivo Antiplasmodial Activity of Detarium microcarpum (Fabaceae) Stem Bark Extract Open
Background: Malaria is a parasitic infection that is common in the tropical and sub-tropical regions of the world. It is estimated to kill one million individuals annually. Detarium microcarpum (Fabaceae family) is used traditionally for t…
View article: Pattern of Cancer in Bauchi
Pattern of Cancer in Bauchi Open
Context: Cancer ranks second among the major causes of death globally. A projection by 2020 indicated that developing countries would account for about 70% of total cancer-related death worldwide. Despite the great threat posed by cancer t…
View article: Anxiety Disorders: Recent Global Approach to Neuro-pathogenesis, Drug Treatment, Cognitive Behavioral Therapy, and Their Implications
Anxiety Disorders: Recent Global Approach to Neuro-pathogenesis, Drug Treatment, Cognitive Behavioral Therapy, and Their Implications Open
Anxiety is a group of mental disorders characterized by the sudden feeling of intense fear, panic, shortness of breath, chest pain, restlessness, GIT problems, insomnia, fatigue, muscle tension, sweating, loss of memory, blurred vision, an…
View article: Knowledge assessment of anti-snake venom among healthcare practitioners in northern Nigeria
Knowledge assessment of anti-snake venom among healthcare practitioners in northern Nigeria Open
Introduction: Anti-snake venom (ASV) is the standard therapy for the management of snakebite envenoming (SBE). Therefore, the knowledge of ASV among healthcare practitioners (HCPs) is essential for achieving optimal clinical outcomes in sn…
View article: Development and validation of antisnake venom knowledge assessment tool (AKAT) for healthcare practitioners
Development and validation of antisnake venom knowledge assessment tool (AKAT) for healthcare practitioners Open
Antisnake venom (ASV) is the only specific and standard treatment for snakebite envenoming worldwide. The knowledge of antivenom dosage, mode of administration, availability, and logistics is essential to the healthcare practitioners (HCPs…
View article: Population Differences in Breast Cancer: Survey in Indigenous African Women Reveals Over-Representation of Triple-Negative Breast Cancer
Population Differences in Breast Cancer: Survey in Indigenous African Women Reveals Over-Representation of Triple-Negative Breast Cancer Open
Compared with white women, black women experience a disproportionate burden of aggressive breast cancer for reasons that remain unknown and understudied. In the first study of its kind, we determined the distribution of molecular subtypes …
View article: Mathematical modelling of COVID-19 transmission and control strategies in the population of Bauchi State, Nigeria
Mathematical modelling of COVID-19 transmission and control strategies in the population of Bauchi State, Nigeria Open
The novel SARS-COV-2 has since been declared a pandemic by the World Health Organization (WHO). The virus has spread from Wuhan city in China in December 2019 to no fewer than 200 countries as at June 2020 and still counting. Nigeria is cu…
View article: Antidepressant-like effects of methanol leaves extract of <I>Leptadenia hastata </I>(Asclepidiaceae) in mice
Antidepressant-like effects of methanol leaves extract of <i>Leptadenia hastata </i>(Asclepidiaceae) in mice Open
Depression is a serious disorder that affects people in all communities across the world, a major cause of disability and morbidity worldwide. The drugs used in its management are associated with adverse effects and delayed response, hence…
View article: Knowledge assessment of snake antivenom among healthcare practitioners involving educational intervention in northern Nigeria: a study protocol
Knowledge assessment of snake antivenom among healthcare practitioners involving educational intervention in northern Nigeria: a study protocol Open
Introduction Snakebite envenoming (SBE) is an important occupational and public health hazard especially in sub-Saharan Africa. For optimum management of SBE, adequate knowledge of Snake antivenom (SAV) is very critical among the healthcar…
View article: Toxicity Study of Potash Extract, “jar Kanwa”: An Earthy Material Consumed for Remedy of various Ailments in Northern Nigeria
Toxicity Study of Potash Extract, “jar Kanwa”: An Earthy Material Consumed for Remedy of various Ailments in Northern Nigeria Open
Potash comprises potassium bearing minerals. These minerals are traditionally used for treatments of many ailments in Northern Nigeria with little knowledge of their safety profile. Acute toxicity (LD50) study of the potash extract was car…
View article: Short-term effect of Tramadol injection on the serum levels of Follicle Stimulating Hormone, Luteinizing Hormone and Testosterone in Male Sahel Goats in Maiduguri, Nigeria
Short-term effect of Tramadol injection on the serum levels of Follicle Stimulating Hormone, Luteinizing Hormone and Testosterone in Male Sahel Goats in Maiduguri, Nigeria Open
Tramadol is a synthetic analogue of codeine. Its mood elevation property and sex enhancement potentials are the main reason for its abuse. The aim of the study was to determine the short-term effect of tramadol administration on Follicle S…
View article: Anxiolytic-Like Effect of Methanol Leaf Extract of Laggera aurita Linn. F. (Asteraceae) in Mice
Anxiolytic-Like Effect of Methanol Leaf Extract of Laggera aurita Linn. F. (Asteraceae) in Mice Open
Background: Laggera aurita belongs to the Asteraceae family; it is an annual herb found growing as weeds in Sub-Saharan Africa, including Nigeria. In Nigeria, Laggera aurita is used as a remedy for paediatric malaria and in the management …