Sanja Huibner
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View article: Temporal dynamics of the vaginal microbiome and host immune markers before, during, and after metronidazole treatment for bacterial vaginosis
Temporal dynamics of the vaginal microbiome and host immune markers before, during, and after metronidazole treatment for bacterial vaginosis Open
This study analyzed metagenomic and immune marker profiles of seven individuals before, during, and after a 7-day course of metronidazole treatment for bacterial vaginosis (BV). Treatment reduced BV-associated bacteria and immune marker le…
View article: Temporal Dynamics of the Vaginal Microbiome and Host Immune Markers Before, During, and After Metronidazole Treatment for Bacterial Vaginosis
Temporal Dynamics of the Vaginal Microbiome and Host Immune Markers Before, During, and After Metronidazole Treatment for Bacterial Vaginosis Open
This study analyzed metagenomic and immune marker profiles of seven individuals before, during, and after a 7-day course of metronidazole treatment for bacterial vaginosis (BV). Treatment reduced BV-associated bacteria and immune marker le…
View article: Quantitative profiling of the vaginal microbiota improves resolution of the microbiota-immune axis
Quantitative profiling of the vaginal microbiota improves resolution of the microbiota-immune axis Open
View article: Gardnerella vaginalis-binding IgA in the urethra of sexually experienced males
Gardnerella vaginalis-binding IgA in the urethra of sexually experienced males Open
View article: Impact of antimicrobials on penile HIV susceptibility and immunology in uncircumcised men: A randomized phase 1/2 clinical trial
Impact of antimicrobials on penile HIV susceptibility and immunology in uncircumcised men: A randomized phase 1/2 clinical trial Open
View article: Are violence, harmful alcohol/substance use and poor mental health associated with increased genital inflammation?: A longitudinal cohort study with HIV-negative female sex workers in Nairobi, Kenya
Are violence, harmful alcohol/substance use and poor mental health associated with increased genital inflammation?: A longitudinal cohort study with HIV-negative female sex workers in Nairobi, Kenya Open
Violence, alcohol use, substance use and poor mental health have been linked with increased HIV acquisition risk, and genital inflammation enhances HIV susceptibility. We examined whether past 6 month experience of these exposures was asso…
View article: Vaginal fungi are associated with treatment-induced shifts in the vaginal microbiota and with a distinct genital immune profile
Vaginal fungi are associated with treatment-induced shifts in the vaginal microbiota and with a distinct genital immune profile Open
Vaginal colonization by fungi may elicit genital inflammation and enhance the risk of adverse reproductive health outcomes, such as HIV acquisition. Cross-sectional studies have linked fungi with an absence of bacterial vaginosis (BV), but…
View article: Vaginal Lactobacillus crispatus persistence following application of a live biotherapeutic product: colonization phenotypes and genital immune impact
Vaginal Lactobacillus crispatus persistence following application of a live biotherapeutic product: colonization phenotypes and genital immune impact Open
Background Bacterial vaginosis (BV) increases HIV acquisition risk, potentially by eliciting genital inflammation. After BV treatment, the vaginal administration of LACTIN-V, a live biotherapeutic containing the Lactobacillus crispatus str…
View article: Microbe-binding antibodies in the female genital tract: associations with the vaginal microbiome and genital immunology
Microbe-binding antibodies in the female genital tract: associations with the vaginal microbiome and genital immunology Open
Background Mucosal antibodies in the gut maintain homeostasis between the host and the local microbiome through the clearance of pathogenic bacteria and the development of immune tolerance to inflammatory bacteria. Whether similar bacteria…
View article: Forced Vaginal Sex and Genital Immune Correlates of HIV Risk: A Prospective Study
Forced Vaginal Sex and Genital Immune Correlates of HIV Risk: A Prospective Study Open
View article: Impact of Antimicrobials on Penile HIV Susceptibility and Immunology in Uncircumcised Men: A Randomized, Open-Label, Phase I/Ii Clinical Trial
Impact of Antimicrobials on Penile HIV Susceptibility and Immunology in Uncircumcised Men: A Randomized, Open-Label, Phase I/Ii Clinical Trial Open
View article: Insertive vaginal sex is associated with altered penile immunology and enrichment of <i>Gardnerella vaginalis</i> in uncircumcised Ugandan men
Insertive vaginal sex is associated with altered penile immunology and enrichment of <i>Gardnerella vaginalis</i> in uncircumcised Ugandan men Open
Problem HIV susceptibility is linked to the penile immune milieu (particularly IL‐8 levels) and microbiome. The effects of insertive vaginal sex itself on penile immunology and microbiota are not well described. Method of study We compared…
View article: Treatment Success Following Standard Antibiotic Treatment for Bacterial Vaginosis Is Not Associated With Pretreatment Genital Immune or Microbial Parameters
Treatment Success Following Standard Antibiotic Treatment for Bacterial Vaginosis Is Not Associated With Pretreatment Genital Immune or Microbial Parameters Open
Background Bacterial vaginosis (BV) is a proinflammatory genital condition associated with adverse reproductive health outcomes, including increased HIV incidence. However, BV recurrence rates are high after standard antibiotic treatment. …
View article: Immune parameters of HIV susceptibility in the female genital tract before and after penile-vaginal sex
Immune parameters of HIV susceptibility in the female genital tract before and after penile-vaginal sex Open
View article: Sustained effect of LACTIN-V (Lactobacillus crispatus CTV-05) on genital immunology following standard bacterial vaginosis treatment: results from a randomised, placebo-controlled trial
Sustained effect of LACTIN-V (Lactobacillus crispatus CTV-05) on genital immunology following standard bacterial vaginosis treatment: results from a randomised, placebo-controlled trial Open
View article: Immune milieu and microbiome of the distal urethra in Ugandan men: impact of penile circumcision and implications for HIV susceptibility
Immune milieu and microbiome of the distal urethra in Ugandan men: impact of penile circumcision and implications for HIV susceptibility Open
Background Coronal sulcus (CS) anaerobe abundance and IL-8 levels are linked to HIV acquisition, and are dramatically reduced after penile circumcision (PC). The distal urethra may be the site of some HIV acquisition before PC, and presuma…
View article: Insertive condom-protected and condomless vaginal sex both have a profound impact on the penile immune correlates of HIV susceptibility
Insertive condom-protected and condomless vaginal sex both have a profound impact on the penile immune correlates of HIV susceptibility Open
The penis is the primary site of HIV acquisition in heterosexual men. Elevated penile inflammatory cytokines increase sexual acquisition risk, and topically applied cytokines enhance foreskin HIV susceptibility in an explant model. However…
View article: The Dietary Inflammatory Index Is Not Associated With Gut Permeability or Biomarkers of Systemic Inflammation in HIV Immunologic Non-responders
The Dietary Inflammatory Index Is Not Associated With Gut Permeability or Biomarkers of Systemic Inflammation in HIV Immunologic Non-responders Open
Immunologic non-responders (INRs) are a subset of individuals living with HIV who have suboptimal blood CD4+ T cell recovery despite effective antiretroviral therapy (ART). They are at an increased risk of serious non-AIDS co-morbidities a…
View article: Insertive vaginal sex has a profound impact on the penile immune correlates of HIV susceptibility
Insertive vaginal sex has a profound impact on the penile immune correlates of HIV susceptibility Open
The penis is the primary site of HIV acquisition in heterosexual men. Elevated penile inflammatory cytokines increase sexual acquisition risk, and topically applied cytokines enhance foreskin HIV susceptibility in an explant model. However…
View article: Activation and gut-homing of peripheral T cells in HIV immunologic non-responders despite long term viral suppression
Activation and gut-homing of peripheral T cells in HIV immunologic non-responders despite long term viral suppression Open
Objective Serious non-AIDS disease events (SNAE) are experienced disproportionately by immunologic non-responders (INRs), HIV-infected individuals who do not restore CD4 T cells in blood despite effective viral suppression. We aimed to cha…
View article: O03.2 The short-term immune impact of bacterial vaginosis treatment is unrelated to Lactobacillus spp. abundance
O03.2 The short-term immune impact of bacterial vaginosis treatment is unrelated to Lactobacillus spp. abundance Open
Background Bacterial vaginosis (BV) induces genital inflammation and enhances HIV acquisition risk, while vaginal Lactobacillus predominance is associated with mucosal immune quiescence and reduced HIV risk. BV treatment reduces vaginal pr…
View article: HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada
HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada Open
View article: The impact of cervical cytobrush sampling on cervico-vaginal immune parameters and microbiota relevant to HIV susceptibility
The impact of cervical cytobrush sampling on cervico-vaginal immune parameters and microbiota relevant to HIV susceptibility Open
The immunology and microbiota of the female genital tract (FGT) are key determinants of HIV susceptibility. Cervical cytobrush sampling is a relatively non-invasive method permitting the longitudinal assessment of endocervical immune cells…
View article: HIV RNA Rebound in Seminal Plasma after Antiretroviral Treatment Interruption
HIV RNA Rebound in Seminal Plasma after Antiretroviral Treatment Interruption Open
To cure HIV, we likely need to target the reservoirs in all anatomic compartments. Here, we used sophisticated statistical and phylogenetic methods to analyze blood and semen samples collected from 12 persons with HIV who began antiretrovi…
View article: Impact of Standard Bacterial Vaginosis Treatment on the Genital Microbiota, Immune Milieu, and Ex Vivo Human Immunodeficiency Virus Susceptibility
Impact of Standard Bacterial Vaginosis Treatment on the Genital Microbiota, Immune Milieu, and Ex Vivo Human Immunodeficiency Virus Susceptibility Open
BV treatment reduced genital CD4+ T-cell HIV susceptibility and IL-1 levels, but dramatically increased the genital chemokines that may enhance HIV susceptibility; the latter effect was related to the restoration of an Lactobacillus iners-…
View article: Distinct Effects of the Cervicovaginal Microbiota and Herpes Simplex Type 2 Infection on Female Genital Tract Immunology
Distinct Effects of the Cervicovaginal Microbiota and Herpes Simplex Type 2 Infection on Female Genital Tract Immunology Open
This suggests that the genital microbiota and HSV-2 infection may influence HIV susceptibility through independent biological mechanisms.
View article: Association of HPV infection and clearance with cervicovaginal immunology and the vaginal microbiota
Association of HPV infection and clearance with cervicovaginal immunology and the vaginal microbiota Open
View article: Clinical and Mucosal Immune Correlates of HIV-1 Semen Levels in Antiretroviral-Naive Men
Clinical and Mucosal Immune Correlates of HIV-1 Semen Levels in Antiretroviral-Naive Men Open
Background This study was done to characterize parameters associated with semen human immunodeficiency virus (HIV)-1 ribonucleic acid (RNA) viral load (VL) variability in HIV-infected, therapy-naive men. Methods Paired blood and semen samp…
View article: Prevalence of Sexually Transmitted Viral and Bacterial Infections in HIV-Positive and HIV-Negative Men Who Have Sex with Men in Toronto
Prevalence of Sexually Transmitted Viral and Bacterial Infections in HIV-Positive and HIV-Negative Men Who Have Sex with Men in Toronto Open
Syphilis and viral infections, including HBV, HCV, HSV-2, CMV, and HR-HPV, were common in this clinic-based population of MSM in Toronto and more frequent among MSM living with HIV. This argues for the implementation of routine screening, …
View article: Correlation of IL-10-producing B cell frequency with HIV-1-specific T cell proliferation in early HIV-1 infection.
Correlation of IL-10-producing B cell frequency with HIV-1-specific T cell proliferation in early HIV-1 infection. Open
CFSE-labeled PBMCs from ten HIV-1 EI subjects were stimulated with HIV-1 Gag pool for 6 d and proliferation of CD4+ and CD8+ T cells were analyzed with flow cytometry. These data were then correlated with contemporane…