Sanjay Gaikwad
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View article: BEYOND THE BINARY: LEGAL RECOGNITION, HEALTHCARE ACCESS, AND SOCIOCULTURAL INCLUSION OF NON-BINARY AND TRANSGENDER IDENTITIES IN A GLOBALIZING WORLD
BEYOND THE BINARY: LEGAL RECOGNITION, HEALTHCARE ACCESS, AND SOCIOCULTURAL INCLUSION OF NON-BINARY AND TRANSGENDER IDENTITIES IN A GLOBALIZING WORLD Open
View article: Neonatal sepsis: A review
Neonatal sepsis: A review Open
View article: Recent Advances in Targeted Therapies for Cancer Treatment
Recent Advances in Targeted Therapies for Cancer Treatment Open
Recent advances in understanding the birth mechanisms underpinning cancer development have driven the design of new remedial approaches, nominated ‘targeted curatives’, that widely intrude with motes or pathways involved in excrescence gro…
View article: Predictive metabolite signatures for risk of progression to active TB from QuantiFERON supernatants of household contacts of TB patients
Predictive metabolite signatures for risk of progression to active TB from QuantiFERON supernatants of household contacts of TB patients Open
The identification of individuals with the greatest risk of progression to active tuberculosis (TB) disease from the huge reservoir of Mycobacterium tuberculosis (Mtb) infected individuals continues to remain an arduous ascen…
View article: Risk-stratified treatment for drug-susceptible pulmonary tuberculosis
Risk-stratified treatment for drug-susceptible pulmonary tuberculosis Open
The Phase 3 randomized controlled trial, TBTC Study 31/ACTG A5349 (NCT02410772) demonstrated that a 4-month rifapentine-moxifloxacin regimen for drug-susceptible pulmonary tuberculosis was safe and effective. The primary efficacy outcome w…
View article: Prevalence, pattern and predictors of fast-food consumption among the undergraduate nursing students of a tertiary level hospital
Prevalence, pattern and predictors of fast-food consumption among the undergraduate nursing students of a tertiary level hospital Open
The global fast-food industry has grown exponentially, significantly impacting public health by contributing to metabolic disorders like obesity and diabetes. This study aimed to investigate the prevalence, patterns, and predictors of fast…
View article: Prevalence of non‐communicable diseases among household contacts of people with tuberculosis: A systematic review and individual participant data meta‐analysis
Prevalence of non‐communicable diseases among household contacts of people with tuberculosis: A systematic review and individual participant data meta‐analysis Open
Objective To investigate the prevalence of non‐communicable diseases among household contacts of people with tuberculosis. Methods We conducted a systematic review and individual participant data meta‐analysis. We searched Medline, Embase …
View article: Clinical and laboratory risk factors for pulmonary tuberculosis recurrence in three pooled Indian cohorts
Clinical and laboratory risk factors for pulmonary tuberculosis recurrence in three pooled Indian cohorts Open
Some individuals with drug-susceptible pulmonary tuberculosis (PTB) experience tuberculosis recurrence. To evaluate the incidence of and risk factors for recurrence following completion of antituberculosis therapy, we pooled data from thre…
View article: Factors Associated With Unfavorable Treatment Outcomes Among Persons With Pulmonary Tuberculosis: A Multicentric Prospective Cohort Study From India
Factors Associated With Unfavorable Treatment Outcomes Among Persons With Pulmonary Tuberculosis: A Multicentric Prospective Cohort Study From India Open
In this prospective cohort of 2006 individuals with drug-susceptible tuberculosis in India, 18% had unfavorable treatment outcomes (4.7% treatment failure, 2.5% recurrent infection, 4.1% death, 6.8% loss to follow-up) over a median 12-mont…
View article: Undernourished Household Contacts Are at Increased Risk of Tuberculosis (TB) Disease, but not TB Infection—a Multicenter Prospective Cohort Analysis
Undernourished Household Contacts Are at Increased Risk of Tuberculosis (TB) Disease, but not TB Infection—a Multicenter Prospective Cohort Analysis Open
Undernutrition is the leading risk factor for tuberculosis (TB) globally and in India. This multicenter prospective cohort analysis from India suggests that undernutrition is associated with increased risk of TB disease but not TB infectio…
View article: The sound of silent RNA in tuberculosis and the lncRNA role on infection
The sound of silent RNA in tuberculosis and the lncRNA role on infection Open
Tuberculosis (TB) is one of the leading causes of death worldwide, and Diabetes Mellitus is one of the major comorbidities (TB/DM) associated with the disease. A total of 103 differentially expressed ncRNAs have been identified in the TB a…
View article: Early Microbiologic Markers of Pulmonary Tuberculosis Treatment Outcomes
Early Microbiologic Markers of Pulmonary Tuberculosis Treatment Outcomes Open
Rationale: Earlier biomarkers of pulmonary tuberculosis (PTB) treatment outcomes are critical to monitor shortened anti-TB treatment (ATT). Objectives: To identify early microbiologic markers of unfavorable TB treatment outco…
View article: Glycated Hemoglobin Trajectories and Their Association With Treatment Outcomes Among Patients With Pulmonary TB in India
Glycated Hemoglobin Trajectories and Their Association With Treatment Outcomes Among Patients With Pulmonary TB in India Open
View article: 1-Year Incidence of Tuberculosis Infection and Disease Among Household Contacts of Rifampin- and Multidrug-Resistant Tuberculosis
1-Year Incidence of Tuberculosis Infection and Disease Among Household Contacts of Rifampin- and Multidrug-Resistant Tuberculosis Open
Background Tuberculosis infection (TBI) and TB disease (TBD) incidence remains poorly described following household contact (HHC) rifampin-/multidrug-resistant TB exposure. We sought to characterize TBI and TBD incidence at 1 year in HHCs …
View article: A multi-center, prospective cohort study of whole blood gene expression in the tuberculosis-diabetes interaction
A multi-center, prospective cohort study of whole blood gene expression in the tuberculosis-diabetes interaction Open
View article: Factors associated with prevalent Mycobacterium tuberculosis infection and disease among adolescents and adults exposed to rifampin-resistant tuberculosis in the household
Factors associated with prevalent Mycobacterium tuberculosis infection and disease among adolescents and adults exposed to rifampin-resistant tuberculosis in the household Open
Background Understanding factors associated with prevalent Mycobacterium tuberculosis infection and prevalent TB disease in household contacts of patients with drug-resistant tuberculosis (TB) may be useful for TB program staff conducting …
View article: Characterising cause of death among people treated for drug-susceptible TB in India
Characterising cause of death among people treated for drug-susceptible TB in India Open
View article: Impact of Undernutrition on Tuberculosis Treatment Outcomes in India: A Multicenter, Prospective, Cohort Analysis
Impact of Undernutrition on Tuberculosis Treatment Outcomes in India: A Multicenter, Prospective, Cohort Analysis Open
Background Undernutrition is the leading risk factor for tuberculosis (TB) globally. Its impact on treatment outcomes is poorly defined. Methods We conducted a prospective cohort analysis of adults with drug-sensitive pulmonary TB at 5 sit…
View article: Sex Differences in TB Clinical Presentation, Drug Exposure, and Treatment Outcomes in India
Sex Differences in TB Clinical Presentation, Drug Exposure, and Treatment Outcomes in India Open
View article: Concomitant pulmonary disease is common among patients with extrapulmonary TB
Concomitant pulmonary disease is common among patients with extrapulmonary TB Open
BACKGROUND: Microbiologic screening of extrapulmonary TB (EPTB) patients could inform recommendations for aerosol precautions and close contact prophylaxis. However, this is currently not routinely recommended in India. Therefore, we estim…
View article: Impact of Undernutrition on Tuberculosis Treatment Outcomes in India: A Multicenter Prospective Cohort Analysis
Impact of Undernutrition on Tuberculosis Treatment Outcomes in India: A Multicenter Prospective Cohort Analysis Open
View article: Baseline IL-6 is a biomarker for unfavourable tuberculosis treatment outcomes: a multisite discovery and validation study
Baseline IL-6 is a biomarker for unfavourable tuberculosis treatment outcomes: a multisite discovery and validation study Open
Background Biomarkers of unfavourable tuberculosis (TB) treatment outcomes are needed to accelerate new drug and regimen development. Whether plasma cytokine levels can predict unfavourable TB treatment outcomes is unclear. Methods We iden…
View article: Host lipidome and tuberculosis treatment failure
Host lipidome and tuberculosis treatment failure Open
Introduction Host lipids play important roles in tuberculosis (TB) pathogenesis. Whether host lipids at TB treatment initiation (baseline) affect subsequent treatment outcomes has not been well characterised. We used unbiased lipidomics to…
View article: Diabetes Mellitus and Tuberculosis Treatment Outcomes in Pune, India
Diabetes Mellitus and Tuberculosis Treatment Outcomes in Pune, India Open
Background Diabetes mellitus (DM) increases the risk of tuberculosis (TB) disease. Knowledge of the impact of DM on TB treatment outcomes is primarily based on retrospective studies. Methods We conducted a prospective cohort study of new p…
View article: Higher interleukin-6 levels and changes in transforming growth factor-β are associated with lung impairment in pulmonary tuberculosis
Higher interleukin-6 levels and changes in transforming growth factor-β are associated with lung impairment in pulmonary tuberculosis Open
Higher levels of IL-6 and slow-to-resolve TGF-β are associated with lung impairment in treated tuberculosis. These results have important implications for clinical trials of immunomodulatory therapies to prevent tuberculosis-associated …
View article: Tuberculosis preventive treatment should be considered for all household contacts of pulmonary tuberculosis patients in India
Tuberculosis preventive treatment should be considered for all household contacts of pulmonary tuberculosis patients in India Open
The World Health Organization (WHO) recently changed its guidance for tuberculosis (TB) preventive treatment (TPT) recommending TPT for all pulmonary TB (PTB) exposed household contacts (HHC) to prevent incident TB disease (iTBD), regardle…
View article: Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes
Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes Open
View article: Correction: Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored
Correction: Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored Open
[This corrects the article DOI: 10.1371/journal.pone.0220507.].
View article: Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored
Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored Open
[This corrects the article DOI: 10.1371/journal.pone.0220507.].
View article: Infection free “resisters” among household contacts of adult pulmonary tuberculosis
Infection free “resisters” among household contacts of adult pulmonary tuberculosis Open
Despite substantial exposure to infectious pulmonary tuberculosis (TB) cases, some household contacts (HHC) never acquire latent TB infection (LTBI). Characterizing these "resisters" can inform who to study immunologically for the developm…