Sanjay Mahant
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View article: Low‐value care and variation in practice in the care of children hospitalized with bronchiolitis in Canada (CareBEST): Protocol for a multi‐center prospective cohort study
Low‐value care and variation in practice in the care of children hospitalized with bronchiolitis in Canada (CareBEST): Protocol for a multi‐center prospective cohort study Open
Introduction Low‐value care refers to health services for which the potential harms or costs outweigh the benefits of use. Bronchiolitis is the most common and among the most costly causes of pediatric hospitalizations. Evidence consistent…
View article: Most costly and prevalent reasons for hospitalization in children with medical complexity in Ontario, Canada
Most costly and prevalent reasons for hospitalization in children with medical complexity in Ontario, Canada Open
Background and Objectives Children with medical complexity (CMC) have chronic health conditions often associated with functional limitations. CMC comprise 1%–5% of the pediatric population. In Canada, their care accounts for one‐third of p…
View article: Methods for engaging vulnerable and marginalized children through community based participatory research: a scoping review
Methods for engaging vulnerable and marginalized children through community based participatory research: a scoping review Open
View article: Adult Hemolytic Uremic Syndrome as a Diagnostic Challenge
Adult Hemolytic Uremic Syndrome as a Diagnostic Challenge Open
Hemolytic uremic syndrome (HUS) is a rare but serious condition in adults, typically characterized by a triad of microangiopathic hemolytic anemia (MAHA), thrombocytopenia, and acute kidney injury (AKI). While most commonly associated with…
View article: Interhospital variation in the management of Brief Resolved Unexplained Events (BRUE) in infants: A Canadian multicenter cohort study
Interhospital variation in the management of Brief Resolved Unexplained Events (BRUE) in infants: A Canadian multicenter cohort study Open
Background Guidelines on Brief Resolved Unexplained Event (BRUE) only provide recommendations for infants categorized at lower risk. However, most infants fall into the higher‐risk category, leaving management decisions to individual clini…
View article: Leadership & professional development: Faculty awards: Intentional pursuit, collective recognition
Leadership & professional development: Faculty awards: Intentional pursuit, collective recognition Open
View article: Impaired Drug Metabolism Caused by Compound Heterozygous Loss‐of‐Function Variants in <i>CYP3A4</i>: A Case Report
Impaired Drug Metabolism Caused by Compound Heterozygous Loss‐of‐Function Variants in <i>CYP3A4</i>: A Case Report Open
Recent consensus guidelines recommend including *22 as the only CYP3A4 variant in pharmacogenetic test panels, given the presence of sufficient functional data as well as a relatively high minor allele frequency. We here describe the clini…
View article: Risk Factors for Severe Disease Among Children Hospitalized With Respiratory Syncytial Virus
Risk Factors for Severe Disease Among Children Hospitalized With Respiratory Syncytial Virus Open
Importance A resurgence of respiratory syncytial virus (RSV)–associated acute respiratory tract infection (ARI) was observed in 2022 and 2023 after the COVID-19 pandemic. Changes in the demographic characteristics, disease severity, and ou…
View article: Performance of the World Health Organization (WHO) severe acute respiratory infection (SARI) case definitions in hospitalized children and youth: cross-sectional study
Performance of the World Health Organization (WHO) severe acute respiratory infection (SARI) case definitions in hospitalized children and youth: cross-sectional study Open
Public Health Agency of Canada, SickKids Foundation, BC Children's Hospital.
View article: Dexamethasone regime and clinical outcomes in children hospitalized with croup: A cohort study
Dexamethasone regime and clinical outcomes in children hospitalized with croup: A cohort study Open
Background High‐quality trial evidence supports the use of one dose of dexamethasone in the outpatient management of croup; however, there are no inpatient trials, and the optimal treatment regimen for the inpatient management of croup rem…
View article: International Networks for Pediatric Inpatient Research and Excellence (INSPIRE): A global initiative in pediatric hospital medicine
International Networks for Pediatric Inpatient Research and Excellence (INSPIRE): A global initiative in pediatric hospital medicine Open
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View article: Mental Health Hospitalizations in Canadian Children, Adolescents, and Young Adults Over the COVID-19 Pandemic
Mental Health Hospitalizations in Canadian Children, Adolescents, and Young Adults Over the COVID-19 Pandemic Open
Importance The COVID-19 pandemic resulted in multiple socially restrictive public health measures and reported negative mental health impacts in youths. Few studies have evaluated incidence rates by sex, region, and social determinants acr…
View article: Pandemic Stringency Measures and Hospital Admissions for Eating Disorders
Pandemic Stringency Measures and Hospital Admissions for Eating Disorders Open
Importance Hospitalizations for eating disorders rose dramatically during the COVID-19 pandemic. Public health restrictions, or stringency, are believed to have played a role in exacerbating eating disorders. Few studies of eating disorder…
View article: Pediatric Respiratory Syncytial Virus Hospitalizations, 2017-2023
Pediatric Respiratory Syncytial Virus Hospitalizations, 2017-2023 Open
Importance Respiratory syncytial virus (RSV) transmission was disrupted worldwide following the COVID-19 pandemic, and further study is required to better understand these changes. Objective To compare observed and expected RSV hospital an…
View article: Prioritization of Randomized Clinical Trial Questions for Children Hospitalized With Common Conditions
Prioritization of Randomized Clinical Trial Questions for Children Hospitalized With Common Conditions Open
Importance There is a lack of randomized clinical trial (RCT) data to guide many routine decisions in the care of children hospitalized for common conditions. A first step in addressing the shortage of RCTs for this population is to identi…
View article: Sociodemographic Factors and Trends in Bronchiolitis-Related Emergency Department Visit and Hospitalization Rates
Sociodemographic Factors and Trends in Bronchiolitis-Related Emergency Department Visit and Hospitalization Rates Open
Importance Bronchiolitis is the most common and most cumulatively expensive condition in pediatric hospital care. Few population-based studies have examined health inequalities in bronchiolitis outcomes over time. Objective To examine tren…
View article: Recurrent Intensive Care Episodes and Mortality Among Children With Severe Neurologic Impairment
Recurrent Intensive Care Episodes and Mortality Among Children With Severe Neurologic Impairment Open
Importance Children requiring care in a pediatric intensive care unit (PICU) are known to have increased risk of subsequent mortality. Children with severe neurologic impairment (SNI)—who carry neurologic or genetic diagnoses with function…
View article: Severe Respiratory Disease Among Children With and Without Medical Complexity During the COVID-19 Pandemic
Severe Respiratory Disease Among Children With and Without Medical Complexity During the COVID-19 Pandemic Open
Importance Severe respiratory disease declined during the COVID-19 pandemic, partially due to decreased circulation of respiratory pathogens. However, the outcomes of children with higher risk have not been described using population-based…
View article: 94 Understanding Parental Behaviours Related to Infant Sleep Environment
94 Understanding Parental Behaviours Related to Infant Sleep Environment Open
Introduction/Background Sudden unexplained death in infants continues to make up a significant proportion of infant deaths. Despite wide dissemination of Canadian Paediatric Society and American Academy of Paediatrics safe sleep recommenda…
View article: 45 Variation in the Management of Hospitalized Children with Orbital Cellulitis over Ten Years
45 Variation in the Management of Hospitalized Children with Orbital Cellulitis over Ten Years Open
Background Management of children with periorbital and orbital infections is multifaceted and interdisciplinary. However, no clinical practice guidelines exist to guide the evaluation and management of orbital cellulitis, leading to highly…
View article: Shifts in the Hospital Care of Children in the US—A Health Equity Challenge
Shifts in the Hospital Care of Children in the US—A Health Equity Challenge Open
JoAnna K. Leyenaar, MD, PhD, MPH; Seneca D. Freyleue, MS; Mary Arakelyan, MPH; David C. Goodman, MD, MS; A. James O'Malley, PhD
View article: 46 Association of Empiric Antibiotic Selection on Clinical Outcomes in Hospitalized Children with Severe Orbital Infections: A Multicenter Cohort Study
46 Association of Empiric Antibiotic Selection on Clinical Outcomes in Hospitalized Children with Severe Orbital Infections: A Multicenter Cohort Study Open
Background Antibiotic selection in children with periorbital and orbital infections is often empiric and regimens vary widely among institutions in their spectrum and inclusion of anti-anaerobic and anti-staphylococcal agents. Objectives C…
View article: Exploring the lived experience of patients and families who speak language other than English (LOE) for healthcare: developing a qualitative study
Exploring the lived experience of patients and families who speak language other than English (LOE) for healthcare: developing a qualitative study Open
View article: Diagnostic test accuracy of ultrasound for orbital cellulitis: A systematic review
Diagnostic test accuracy of ultrasound for orbital cellulitis: A systematic review Open
Background Periorbital and orbital cellulitis are inflammatory conditions of the eye that can be difficult to distinguish using clinical examination alone. Computer tomography (CT) scans are often used to differentiate these two infections…
View article: Kidney Ultrasonography After First Febrile Urinary Tract Infection in Children
Kidney Ultrasonography After First Febrile Urinary Tract Infection in Children Open
Importance Controversy exists on the clinical utility of kidney ultrasonography after first febrile urinary tract infection (UTI), and clinical practice guideline recommendations vary. Objective To determine the prevalence of urinary tract…
View article: Improving health outcomes for patients and families with preferred language other than English or French (PLOEF)
Improving health outcomes for patients and families with preferred language other than English or French (PLOEF) Open
Equitable care considers the unique needs of an individual—including social determinants of health such as language, race, and gender. Health equity and providing equitable care are considered fundamental to medicine, however, in practice …
View article: Clinical characteristics of children with severe neurologic impairment: A scoping review
Clinical characteristics of children with severe neurologic impairment: A scoping review Open
Objective The aim of this study is to extrapolate the clinical features of children with severe neurologic impairment (SNI) based on the functional characteristics and comorbidities described in published studies. Methods Four databases we…
View article: Cost-effectiveness of Intermittent vs Continuous Pulse Oximetry Monitoring in Infants Hospitalized With Stabilized Bronchiolitis
Cost-effectiveness of Intermittent vs Continuous Pulse Oximetry Monitoring in Infants Hospitalized With Stabilized Bronchiolitis Open
Importance Pulse oximetry is a noninvasive technology that is integral to the supportive care of hospitalized infants with bronchiolitis. A multicenter, randomized trial comparing the effectiveness of intermittent vs continuous pulse oxime…
View article: 74 Patient-oriented research priorities for pediatric hospital care in Canada: a James Lind Alliance Priority Setting Partnership
74 Patient-oriented research priorities for pediatric hospital care in Canada: a James Lind Alliance Priority Setting Partnership Open
Background The largest population of paediatric patients cared for in hospital are those with medical conditions managed in general paediatric inpatient units (GPIUs). Despite the large burden, there is a lack of high-quality research focu…
View article: 66 Trends in bronchiolitis emergency department visits in Ontario, 2004-2018: A population-based cohort study
66 Trends in bronchiolitis emergency department visits in Ontario, 2004-2018: A population-based cohort study Open
Background Bronchiolitis is the most common lower respiratory tract infection in children and places a significant burden on the health care system. There have been few population-based studies describing trends in emergency department (ED…