Sanjay Mehendale
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View article: Occurrence and Contributing Factors for Amputation in Individuals Hospitalized with Acute Diabetic Foot Complications at a Tertiary Care Center in Western India, and Its Association with Glycemic Status on Admission
Occurrence and Contributing Factors for Amputation in Individuals Hospitalized with Acute Diabetic Foot Complications at a Tertiary Care Center in Western India, and Its Association with Glycemic Status on Admission Open
Background: Limited research has been carried out to explore the relationship between HbA1c levels and the probability of surgical limb loss among Indian patients with diabetic foot ulcers (DFUs). Objectives: The objectives of the study we…
View article: Phenotyping of asthma population based on inflammatory blood biomarkers and characterisation of phenotypes depending on asthma control, frequency of exacerbations, and associated comorbidities
Phenotyping of asthma population based on inflammatory blood biomarkers and characterisation of phenotypes depending on asthma control, frequency of exacerbations, and associated comorbidities Open
Background and Objective: There are very few studies in the Indian population on the prevalence of phenotypes in asthma patients. To phenotype patients with bronchial asthma and characterise the phenotypes based on asthma control, exacerba…
View article: Progress and challenges towards eliminating vertical transmission of HIV in India
Progress and challenges towards eliminating vertical transmission of HIV in India Open
India has intensified efforts towards elimination of vertical transmission of HIV (EVTH) as part of National AIDS and STD Control Programme-V (NACP-V). We present the progress in achieving NACP-V's EVTH goal as of year 2023-24. We analysed…
View article: Programmatic mapping and population size estimation of key population in India: Method and findings
Programmatic mapping and population size estimation of key population in India: Method and findings Open
India has the world’s second-largest HIV burden. Key populations of female sex workers (FSW), men who have sex with men (MSM), hijra/transgender (H/TG) people, and people who inject drugs (PWID), are disproportionately affected by the HIV …
View article: Incremental cost of treating antimicrobial-resistant infections among hospitalised patients in India: a cohort study
Incremental cost of treating antimicrobial-resistant infections among hospitalised patients in India: a cohort study Open
Background Accurate estimates of incremental cost (IC) attributable to antimicrobial resistance (AMR) provide information of immense public health importance to the policy makers. Here, we present the IC from patient perspective for treati…
View article: Projected impact of fast-tracking of anti-retroviral treatment coverage on vertical transmission of HIV in India
Projected impact of fast-tracking of anti-retroviral treatment coverage on vertical transmission of HIV in India Open
One of the five high-level goals under Phase V of the National AIDS and STD Control Programme (NACP) of the Government of India is the elimination of vertical transmission of HIV. In this paper, we estimate the potential impact of maintain…
View article: The Frequency, Causes and Patterns of Asymptomatic Cardiac Arrhythmias in Patients on Maintenance Hemodialysis
The Frequency, Causes and Patterns of Asymptomatic Cardiac Arrhythmias in Patients on Maintenance Hemodialysis Open
Background The knowledge of the incidence of non-severe and clinically significant arrhythmias is limited in patients with chronic kidney disease (CKD). The present study was conducted to determine the incidence, pattern and identify the f…
View article: PreVenTB trial: protocol for evaluation of efficacy and safety of two vaccines VPM1002 and Immuvac (Mw) in preventing tuberculosis (TB) in healthy household contacts of newly diagnosed sputum smear-positive pulmonary TB patients: phase III, randomised, double-blind, three-arm placebo-controlled trial
PreVenTB trial: protocol for evaluation of efficacy and safety of two vaccines VPM1002 and Immuvac (Mw) in preventing tuberculosis (TB) in healthy household contacts of newly diagnosed sputum smear-positive pulmonary TB patients: phase III, randomised, double-blind, three-arm placebo-controlled trial Open
Introduction Tuberculosis (TB) continues to be one of the deadliest infectious diseases over the centuries, killing more people worldwide than any other single infectious disease. There is an urgent need for additional strategies which can…
View article: Post-campaign coverage evaluation of a measles and rubella supplementary immunization activity in five districts in India, 2019–2020
Post-campaign coverage evaluation of a measles and rubella supplementary immunization activity in five districts in India, 2019–2020 Open
Background In alignment with the Measles and Rubella (MR) Strategic Elimination plan, India conducted a mass measles and rubella vaccination campaign across the country between 2017 and 2020 to provide a dose of MR containing vaccine to al…
View article: Measles and rubella seroprevalence in adults using residual blood samples from health facilities and household serosurveys in Palghar District, Maharashtra, India, 2018 – 2019
Measles and rubella seroprevalence in adults using residual blood samples from health facilities and household serosurveys in Palghar District, Maharashtra, India, 2018 – 2019 Open
Residual blood specimens collected at health facilities may be a source of samples for serosurveys of adults, a population often neglected in community-based serosurveys. Anonymized residual blood specimens were collected from individuals …
View article: Increased measles and rubella seroprevalence in children using residual blood samples from health facilities and household serosurveys after supplementary immunization activities in two districts in India
Increased measles and rubella seroprevalence in children using residual blood samples from health facilities and household serosurveys after supplementary immunization activities in two districts in India Open
Residual blood specimens provide a sample repository that could be analyzed to estimate and track changes in seroprevalence with fewer resources than household-based surveys. We conducted parallel facility and community-based cross-section…
View article: Augmenting progress on the elimination of vertical transmissions of HIV in India: Insights from Spectrum-based HIV burden estimations
Augmenting progress on the elimination of vertical transmissions of HIV in India: Insights from Spectrum-based HIV burden estimations Open
The government of India has adopted the elimination of vertical transmission of HIV as one of the five high-level goals under phase V of the National AIDS and STD Control Programme (NACP). In this paper, we present the data from HIV estima…
View article: Added value of the measles-rubella supplementary immunization activity in reaching unvaccinated and under-vaccinated children, a cross-sectional study in five Indian districts, 2018–20
Added value of the measles-rubella supplementary immunization activity in reaching unvaccinated and under-vaccinated children, a cross-sectional study in five Indian districts, 2018–20 Open
We demonstrated the MR SIA provided considerable added value in terms of measles vaccination coverage, although there was variability across districts due to differences in routine and SIA coverage, and which children were reached by the S…
View article: Comparison of prevention of parent-to-child HIV transmission programme & national biennial HIV sentinel surveillance data for tracking HIV epidemic in India
Comparison of prevention of parent-to-child HIV transmission programme & national biennial HIV sentinel surveillance data for tracking HIV epidemic in India Open
Background & objectives: HIV sentinel surveillance (HSS) among antenatal women in India has been used to track the epidemic for many years. However, reliable tracking at the local level is not possible as ANC sentinel sites are limited in …
View article: Experiences of sharing results of community based serosurvey with participants in a district of Maharashtra, India
Experiences of sharing results of community based serosurvey with participants in a district of Maharashtra, India Open
A growing number of organisations, including medical associations, recommend that research subjects should be given the option of being informed about the general outcome and results of the study. We recently completed a study involving ni…
View article: Non-communicable diseases as a major contributor to deaths in 12 tribal districts in India
Non-communicable diseases as a major contributor to deaths in 12 tribal districts in India Open
Background & objectives: Non-communicable diseases (NCDs) are the leading cause of death in India. Although studies have reported a high prevalence of NCD in tribal populations, there are limited data pertaining mortality due to NCDs. Ther…
View article: Diversity in HIV epidemic transitions in India: An application of HIV epidemiological metrices and benchmarks
Diversity in HIV epidemic transitions in India: An application of HIV epidemiological metrices and benchmarks Open
Background The Joint United Nations Programme on AIDS (UNAIDS) has emphasized on the incidence-prevalence ratio (IPR) and incidence-mortality ratio (IMR) to measure the progress in HIV epidemic control. In this paper, we describe the statu…
View article: Sero-Surveillance to Monitor the Trend of SARS-CoV-2 Infection Transmission in India: Study Protocol for a Multi Site, Community Based Longitudinal Cohort Study
Sero-Surveillance to Monitor the Trend of SARS-CoV-2 Infection Transmission in India: Study Protocol for a Multi Site, Community Based Longitudinal Cohort Study Open
Introduction Large-scale sero-prevalence studies with representation from all age groups are required to estimate the true burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in the community. Serial serologic…
View article: Injecting drug use & HIV prevalence among female sex workers: Evidence from the National Integrated Biological & Behavioural Surveillance, India
Injecting drug use & HIV prevalence among female sex workers: Evidence from the National Integrated Biological & Behavioural Surveillance, India Open
Background & objectives: Female sex workers (FSWs) who inject drugs (FSW-IDs) have a higher risk of HIV infection and transmission. Understanding the socio-demographic characteristics and other risk behaviours among FSW-IDs will help in st…
View article: Low risk of relapse and deformity among leprosy patients who completed multi-drug therapy regimen from 2005 to 2010: A cohort study from four districts in South India
Low risk of relapse and deformity among leprosy patients who completed multi-drug therapy regimen from 2005 to 2010: A cohort study from four districts in South India Open
Introduction Relapse of leprosy among patients released from treatment (RFT) is an indicator of the success of anti-leprosy treatment. Due to inadequate follow-up, relapse in leprosy patients after RFT is not systematically documented in I…
View article: The Evolution of Regulatory Elements in the Emerging Promoter-Variant Strains of HIV-1 Subtype C
The Evolution of Regulatory Elements in the Emerging Promoter-Variant Strains of HIV-1 Subtype C Open
In a multicentric, observational, investigator-blinded, and longitudinal clinical study of 764 ART-naïve subjects, we identified nine different promoter variant strains of HIV-1 subtype C (HIV-1C) emerging in the Indian population, with so…
View article: Implementing Serosurveys in India: Experiences, Lessons Learned, and Recommendations
Implementing Serosurveys in India: Experiences, Lessons Learned, and Recommendations Open
Serological surveillance for vaccine-preventable diseases, such as measles and rubella, can provide direct measures of population immunity across age groups, identify gaps in immunity, and document changes in immunity over time. Rigorously…
View article: Optimization and Stability Testing of Four Commercially Available Dried Blood Spot Devices for Estimating Measles and Rubella IgG Antibodies
Optimization and Stability Testing of Four Commercially Available Dried Blood Spot Devices for Estimating Measles and Rubella IgG Antibodies Open
Dried blood spot (DBS) collection offers various advantages over conventional methods of blood collection, especially when collecting and transporting samples for a serosurvey. Yet use of DBS requires additional processing steps in the lab…
View article: District-level HIV estimates using the spectrum model in five states of India, 2017
District-level HIV estimates using the spectrum model in five states of India, 2017 Open
Decentralized response has been the hallmark of the National AIDS Control Programme in India. District-level HIV burden estimates quantifying the distribution of the epidemics are needed to enhance this decentralized response further to mo…
View article: Diagnostic Accuracy of Dried Blood Spots Collected on HemaSpot HF Devices Compared to Venous Blood Specimens To Estimate Measles and Rubella Seroprevalence
Diagnostic Accuracy of Dried Blood Spots Collected on HemaSpot HF Devices Compared to Venous Blood Specimens To Estimate Measles and Rubella Seroprevalence Open
Dried blood spot (DBS) collection provides an easy, practical, and acceptable alternative to venous blood collection, especially for community-based studies, provided that results from DBS are accurate. We demonstrated high sensitivity and…
View article: Hospital-based sentinel surveillance for bacterial meningitis in under-five children prior to the introduction of the PCV13 in India
Hospital-based sentinel surveillance for bacterial meningitis in under-five children prior to the introduction of the PCV13 in India Open
The results are representative of the burden of bacterial meningitis among under-five children in India. The findings were useful in rolling out PCV in the National Immunization Program. The non-susceptibility to penicillin and multidrug r…