Sanjeev Kharel
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View article: Abstract 363: Cerebrovascular Events and Associated Risk Factors in Cervical Fibromuscular Dysplasia: A Systematic Review and Meta‐Analysis
Abstract 363: Cerebrovascular Events and Associated Risk Factors in Cervical Fibromuscular Dysplasia: A Systematic Review and Meta‐Analysis Open
Introduction Cervical fibromuscular dysplasia (FMD) is a non‐inflammatory arteriopathy of cervical arteries that causes arterial stenosis and structural fragility. Due to multifactorial pathophysiology causing arterial dissection, aneurysm…
View article: Comparison of Outcomes Between Primary Laryngotracheal Reconstruction and Partial Cricotracheal Resection in Moderate Grade Pediatric Subglottic Stenosis: A Systematic Review and Meta‐Analysis
Comparison of Outcomes Between Primary Laryngotracheal Reconstruction and Partial Cricotracheal Resection in Moderate Grade Pediatric Subglottic Stenosis: A Systematic Review and Meta‐Analysis Open
Objective This systematic review and meta‐analysis compare the outcomes of primary laryngotracheal reconstruction (LTR) and partial cricotracheal resection (PCTR) in managing moderate‐grade pediatric subglottic stenosis (severe Grade II an…
View article: Comparative Outcomes of Doxorubicin and Cyclophosphamide with Sequential versus Concurrent Paclitaxel in the Adjuvant Treatment of Non-Metastatic Breast Cancer: A Cross-Sectional Analytical Study
Comparative Outcomes of Doxorubicin and Cyclophosphamide with Sequential versus Concurrent Paclitaxel in the Adjuvant Treatment of Non-Metastatic Breast Cancer: A Cross-Sectional Analytical Study Open
Introduction: Studies have compared the efficacy and toxicities of doxorubicin and cyclophosphamide every three weeks for four cycles followed by four cycles of paclitaxel every three weeks (AC/T); with paclitaxel, doxorubicin, and cycloph…
View article: Histopathological Profile of Lung Cancer: A Single-Center Study from Nepal
Histopathological Profile of Lung Cancer: A Single-Center Study from Nepal Open
Introduction Lung cancer remains the leading cause of cancer-related mortality globally, accounting for approximately 18% of all cancer death. Despite the global prevalence of lung cancer, epidemiological data from Nepal remain limited. Th…
View article: WCN25-811 p-ANCA Vasculitis-Induced Renal Impairment with Concurrent Splenic Artery Aneurysm in a Nepali Woman with Rheumatoid Arthritis: A Rare Overlap Syndrome or Co-existing Occurrence
WCN25-811 p-ANCA Vasculitis-Induced Renal Impairment with Concurrent Splenic Artery Aneurysm in a Nepali Woman with Rheumatoid Arthritis: A Rare Overlap Syndrome or Co-existing Occurrence Open
View article: Rare Presentation of Hypoparathyroidism with Feautures of Parkinsonism: A Case Report
Rare Presentation of Hypoparathyroidism with Feautures of Parkinsonism: A Case Report Open
This case report presents a 54-year-old female diagnosed with Hypoparathyroidism, manifesting with symptoms of Parkinsonism. The report details the patient's clinical presentation, diagnostic journey, and management strategies. Recognizing…
View article: Growing Need for Web-Based Simulation in Low and Middle-Income Countries: A Narrative Review
Growing Need for Web-Based Simulation in Low and Middle-Income Countries: A Narrative Review Open
Web-based simulation programs are poised to offer a productive means of delivering asynchronous training in healthcare professionals’ education. Similarly, web-based simulation programs could also sponsor specialty-specific, web-based fell…
View article: Comparison of glucagon-like peptide-1 receptor agonists vs. placebo on any cardiovascular events in overweight or obese non-diabetic patients: a systematic review and meta-analysis
Comparison of glucagon-like peptide-1 receptor agonists vs. placebo on any cardiovascular events in overweight or obese non-diabetic patients: a systematic review and meta-analysis Open
Introduction Glucagon-like peptide 1 receptor agonists (GLP-1 RA) have been extensively used to treat obesity in recent years. These novel drugs are effective at reducing body weight and also the risk of major adverse cardiovascular events…
View article: Aspirin Desensitization and Percutaneous Coronary Intervention in a Patient with Aspirin Hypersensitivity and Acute Coronary Syndrome: A Case Report
Aspirin Desensitization and Percutaneous Coronary Intervention in a Patient with Aspirin Hypersensitivity and Acute Coronary Syndrome: A Case Report Open
Hypersensitivity to aspirin is rare disorder occurring in 1.88% of the patients. Aspirin-hypersensitive patients requiring single antiplatelet agent may be treated with clopidogrel, an alternative antiplatelet agent. However, aspirin desen…
View article: Comparison of Safety Of Oral Ivermectin with Topical Permethrin in the Treatment of Scabies: A Comparative Study
Comparison of Safety Of Oral Ivermectin with Topical Permethrin in the Treatment of Scabies: A Comparative Study Open
Introduction: The mite Sarcoptes scabiei var. hominis is the cause of scabies, a skin illness. The Food and Drug Administration (FDA) approves permethrin cream (5%) for the treatment of scabies and is also recommended by the Centers for Di…
View article: Impact of Otitis Media With Effusion in Early Age on Auditory Processing Abilities in Children: A Systematic Review and Meta-Analysis
Impact of Otitis Media With Effusion in Early Age on Auditory Processing Abilities in Children: A Systematic Review and Meta-Analysis Open
Objective: Early-onset otitis media with effusion (OME) can affect the development of the auditory nervous system and thus lead to auditory processing abnormalities. This study aims to review the effect of childhood OME on auditory process…
View article: Anti-epileptic Drugs Use and Increased Risk of Stroke: A Systematic Review
Anti-epileptic Drugs Use and Increased Risk of Stroke: A Systematic Review Open
Background Antiepileptic drugs (AEDs), the predominant treatment for epilepsy, are also utilised for migraine, neuropathic pain, and bipolar disorders, accounting for 1% of usage among the common population. There is a greater risk of stro…
View article: Kisspeptin levels in polycystic ovary syndrome and its manifestations
Kisspeptin levels in polycystic ovary syndrome and its manifestations Open
Background: The altered luteinizing hormone to follicle-stimulating hormone (LH/FSH) ratio- an important component in the pathogenesis of polycystic ovary syndrome (PCOS), is regulated by a brain peptide kisspeptin. This study aimed to exp…
View article: Hormone Receptors and HER2 Status of Patients with Breast Cancer in a Tertiary Center of Nepal: A Descriptive Cross-Sectional Study
Hormone Receptors and HER2 Status of Patients with Breast Cancer in a Tertiary Center of Nepal: A Descriptive Cross-Sectional Study Open
Introduction: The second most prevalent cancer among women in Nepal is breast cancer. The assessment of human epidermal growth factor receptor-2 (HER2), progesterone receptor (PR), and estrogen receptor (ER) status in patients with breast …
View article: Amoxicillin-induced bullous erythema multiforme: a case report
Amoxicillin-induced bullous erythema multiforme: a case report Open
Introduction: Bullous erythema multiforme (BEM), an immune-mediated, acute condition, frequently includes erosion affecting the oral, genital, and/or ocular mucosa in addition to discrete target-like lesions on the skin. BEM has been linke…
View article: Utilization rates of intravenous thrombolysis for acute ischemic stroke in Asian countries:: A systematic review and meta-analysis
Utilization rates of intravenous thrombolysis for acute ischemic stroke in Asian countries:: A systematic review and meta-analysis Open
Background: Despite intravenous thrombolysis (IVT) being used for the treatment of acute ischemic stroke (AIS) for over two decades, its accessibility remains limited in various regions of the world. The Asian region, which experiences the…
View article: Breakage of an orogastric tube in a critically Ill patient: a case report
Breakage of an orogastric tube in a critically Ill patient: a case report Open
Introduction and importance: Orogastric and nasogastric tubes are common methods of enteral feeding. Although the methods of tube feeding are simple, these methods are not free of complications. Case presentation: This case report describe…
View article: Severe hyponatremia as an atypical manifestation of pituitary macroadenoma: a case report
Severe hyponatremia as an atypical manifestation of pituitary macroadenoma: a case report Open
Introduction and importance: Pituitary macroadenoma most commonly presents with visual disturbances, headache, and other symptoms secondary to adeno hypophyseal hormonal deficiencies and usually alleviates after tumor resection. Pituitary …
View article: Wallerian degeneration in the brain after organophosphorus poisoning: a case report
Wallerian degeneration in the brain after organophosphorus poisoning: a case report Open
Introduction and Importance: The type, quantity, and potency of the organophosphorus compound (OPC) taken determine the symptoms of OPC poisoning as well as their severity. The exact etiology for organophosphorus (OP) poisoning delay neuro…
View article: MRI of the brain mimicking autoimmune encephalitis in Sjögren syndrome with chorea: a case report
MRI of the brain mimicking autoimmune encephalitis in Sjögren syndrome with chorea: a case report Open
Introduction and importance: Neurologic manifestations in primary Sjögren syndrome (SS) range in prevalence from 8 to 49%, and most of the studies suggest a prevalence of 20%. The incidence of SS patients developing movement disorders is a…
View article: A Case of Pembrolizumab-Induced Diabetic Ketoacidosis and Hyperthyroidism in a Patient With Recurrent Esophageal Adenocarcinoma
A Case of Pembrolizumab-Induced Diabetic Ketoacidosis and Hyperthyroidism in a Patient With Recurrent Esophageal Adenocarcinoma Open
Immune checkpoint inhibitors (ICI) such as program cell death protein 1 (PD-1) inhibitors are widely used for the treatment of patients with recurrent, locally advanced or metastatic, gastric or gastroesophageal (GE) junction adenocarcinom…
View article: Idiopathic recurrent pyoderma gangrenosum with cobalamin deficiency in a 62-year-old male: a case report
Idiopathic recurrent pyoderma gangrenosum with cobalamin deficiency in a 62-year-old male: a case report Open
Introduction: Pyoderma gangrenosum (PG) is a rare, neither infectious nor gangrenous, neutrophil-mediated inflammatory dermatosis. In 50–70% of cases, systemic disease is the underlying cause, and the remaining is idiopathic. Case Presenta…
View article: Pontine and bilateral cerebellar lesion in osmotic demyelination syndrome associated with uncontrolled type II diabetes mellitus: a case report
Pontine and bilateral cerebellar lesion in osmotic demyelination syndrome associated with uncontrolled type II diabetes mellitus: a case report Open
Introduction and importance: Osmotic demyelination syndrome (ODS) as a result of the hyperosmolar hyperglycemic state is rare and can present with variable neurological manifestation due to lysis of myelin sheath. Case presentation: A 44-y…
View article: Stiff person syndrome in a Nepalese man with uncontrolled diabetes mellitus and ketonuria: A rare case report
Stiff person syndrome in a Nepalese man with uncontrolled diabetes mellitus and ketonuria: A rare case report Open
Stiff Person Syndrome (SPS), a progressive Central Nervous System disorder is accompanied by progressive muscle rigidity, hyperreflexia, and spasms mainly in truncal and proximal leg muscles mainly associated with autoimmune disorders. Her…
View article: Pembrolizumab-induced encephalitis in a patient with renal cell carcinoma post nephrectomy: A case report
Pembrolizumab-induced encephalitis in a patient with renal cell carcinoma post nephrectomy: A case report Open
A new category of immune-related adverse effects has been identified due to increasing use of immune checkpoint inhibitor therapy to treat solid organ cancers. Pembrolizumab approved for renal cell carcinoma also has neurological immune-re…
View article: Future of Monoclonal Antibody Therapy in Parkinson’s Disease
Future of Monoclonal Antibody Therapy in Parkinson’s Disease Open
View article: A rare incidental finding of an isolated S1 butterfly vertebra: A case report
A rare incidental finding of an isolated S1 butterfly vertebra: A case report Open
View article: Levetiracetam versus Oxcarbazepine as monotherapy in newly diagnosed focal epilepsy: A systematic review and meta‐analysis
Levetiracetam versus Oxcarbazepine as monotherapy in newly diagnosed focal epilepsy: A systematic review and meta‐analysis Open
Objective To compare the efficacy and safety of Levetiracetam (LEV) and Oxcarbazepine (OXC) as monotherapy for the treatment of newly diagnosed focal epilepsy. Methods We searched PubMed, Cochrane Library, EMBASE, and Google Scholar from J…
View article: Switching to Tenecteplase from Alteplase for Ischemic Stroke: Is it the Time for Universal Adoption?
Switching to Tenecteplase from Alteplase for Ischemic Stroke: Is it the Time for Universal Adoption? Open
View article: Clinical profile and management of perforation peritonitis in Bharatpur hospital, Nepal: A prospective study
Clinical profile and management of perforation peritonitis in Bharatpur hospital, Nepal: A prospective study Open
Perforation peritonitis is a frequently encountered surgical emergency. Various factors like age, sex, duration, site of perforation, extent of peritonitis and delay in surgical intervention are associated with morbidity and mortality. A s…