Explanipedia

Role of Persistent Necroinflammation in Chronic Tissue Remodelling and Organ Fibrosis Open

S More, Aparajita Ghosh, Onkar P. Kulkarni, Shrikant R. Mulay · 2025

Persistent necroinflammation is a continuous feedback loop between the regulated necrotic cell death and the sustained immune system activation. It has been increasingly recognised as a key driver of chronic tissue remodeling and fibrosis.…

Microshear Bond Strength of Composite to Dentin Using Self-etch and Etch and Rinse Adhesives – A Systematic Review and Meta-analysis Open

Tanvi Satpute, Shrikant R. Mulay, Divya Naik · 2025

Objectives: A systematic review was conducted to determine whether bonding with self-etch (SE) adhesive system is more effective as compared to etch-and-rinse (ER) adhesive system. Background: Dental adhesives are integral in achieving dur…

Role of Pyrrolidine dithiocarbamate in inducing odontoblastic differentiation of dental pulp stem cells Open

Karan Bhargava, S. R. Srinidhi, Shrikant R. Mulay, Ramesh Bhonde, Avinash Kharat , et al. · 2024

Background: Pyrrolidine dithiocarbamate (PDTC) is an efficient, reproducible, and biological antioxidant of clinical utility, which may also be preferred for obtaining human dental pulp stem cells (hDPSCs) for the purpose of tissue enginee…

Evaluating the ability of cultivated odontoblasts to form dentin-like tissue in vitro using fibroblast growth factor and insulin-like growth factor Open

Karan Bhargava, Srinidhi Surya Raghavendra, Shrikant R. Mulay, Ajit Hindlekar, Avinash Kharat , et al. · 2024

Aim: The aim of the study was to evaluate the ability of cultivated odontoblast to form dentin-like tissue using fibroblast growth factor (FGF) and insulin-like growth factor (IGF). Materials and Methods: Dental pulp stem cells (DPSCs) wer…

Comparative Evaluation of Debris Extrusion, Remaining Dentin Thickness and Fracture Resistance of Endodontically Treated Teeth Using Rotary and Reciprocating Endodontic File Systems: An In Vitro Study Open

Prakriti Jaggi, Shrikant R. Mulay, Anita Tandale, Renuka Jadhao, Poonam Joshi , et al. · 2023

Interdisciplinary Management of Teeth With a Complicated Crown Fracture: A Case Report With Follow-Up Checklist Open

Srikurmam Manisha Sai Kiran, Soumya Shetty, Shrikant R. Mulay, Riya A Parwani, Komal Gupta · 2022

Editorial: Negative Regulators of Innate Immunity and Their Role in Host Responses to Injury and Infection Open

Shrikant R. Mulay, Maciej Lech · 2022

EDITORIAL article Front. Immunol., 28 March 2022Sec. Molecular Innate Immunity Volume 13 - 2022 | https://doi.org/10.3389/fimmu.2022.891919

Involvement of Inflammasome Components in Kidney Disease Open

Ana Karina Aranda‐Rivera, Anjali Srivastava, Alfredo Cruz‐Gregorio, José Pedraza‐Chaverrí, Shrikant R. Mulay , et al. · 2022

Inflammasomes are multiprotein complexes with an important role in the innate immune response. Canonical activation of inflammasomes results in caspase-1 activation and maturation of cytokines interleukin-1β and -18. These cytokines can el…

An Imaging and Computational Algorithm for Efficient Identification and Quantification of Neutrophil Extracellular Traps Open

Apurwa Singhal, Shubhi Yadav, Tulika Chandra, Shrikant R. Mulay, Anil Nilkanth Gaikwad , et al. · 2022

Neutrophil extracellular traps (NETs) are associated with multiple disease pathologies including sepsis, asthma, rheumatoid arthritis, cancer, systemic lupus erythematosus, acute respiratory distress syndrome, and COVID-19. NETs, being a d…

Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2 Open

Salwa Naushin, Viren Sardana, Rajat Ujjainiya, Nitin Bhatheja, Rintu Kutum , et al. · 2021

To understand the spread of SARS-CoV2, in August and September 2020, the Council of Scientific and Industrial Research (India) conducted a serosurvey across its constituent laboratories and centers across India. Of 10,427 volunteers, 1058 …

Author response: Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2 Open

Salwa Naushin, Viren Sardana, Rajat Ujjainiya, Nitin Bhatheja, Rintu Kutum , et al. · 2021

Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract To understand the spread of SARS-CoV2, in …

Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV-2 Open

Salwa Naushin, Viren Sardana, Rajat Ujjainiya, Nitin Bhatheja, Rintu Kutum , et al. · 2021

Summary To understand the spread of SARS-CoV2, in August and September 2020, the Council of Scientific and Industrial Research (India), conducted a sero-survey across its constituent laboratories and centers across India. Of 10,427 volunte…

Neutrophil Extracellular Traps Open

Hans‐Joachim Anders, Shrikant R. Mulay · 2020

Neutrophils regulate immune responses during homeostasis as well as disease pathogenesis. Especially, the neutrophils extracellular traps largely contribute to necroinflammation. This book highlights the role of neutrophils and neutrophils…

CCDC 1960751: Experimental Crystal Structure Determination Open

Anna Kletzmayr, Shrikant R. Mulay, Manga Motrapu, Zhi Luo, Hans‐Joachim Anders , et al. · 2020

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Neutrophils and Neutrophil Extracellular Traps Regulate Immune Responses in Health and Disease Open

Shrikant R. Mulay, Hans‐Joachim Anders · 2020

Neutrophils are first responders of antimicrobial host defense and sterile inflammation, and therefore, play important roles during health and disease [...]

Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19 Open

Bhawna Tomar, Hans‐Joachim Anders, Jyaysi Desai, Shrikant R. Mulay · 2020

The COVID-19 pandemic is progressing worldwide with an alarming death toll. There is an urgent need for novel therapeutic strategies to combat potentially fatal complications. Distinctive clinical features of severe COVID-19 include acute …

Crystal Clots as Therapeutic Target in Cholesterol Crystal Embolism Open

Chongxu Shi, Tehyung Kim, Stefanie Steiger, Shrikant R. Mulay, Barbara M. Klinkhammer , et al. · 2020

Rationale: Cholesterol crystal embolism can be a life-threatening complication of advanced atherosclerosis. Pathophysiology and molecular targets for treatment are largely unknown. Objective: We aimed to develop a new animal model of chole…

Inhibitors of Calcium Oxalate Crystallization for the Treatment of Oxalate Nephropathies Open

Anna Kletzmayr, Shrikant R. Mulay, Manga Motrapu, Zhi Luo, Hans‐Joachim Anders , et al. · 2020

Calcium oxalate (CaOx) crystal‐induced nephropathies comprise a range of kidney disorders, for which there are no efficient pharmacological treatments. Although CaOx crystallization inhibitors have been suggested as a therapeutic modality …

Cellular and Molecular Mechanisms of Kidney Injury in 2,8-Dihydroxyadenine Nephropathy Open

Barbara M. Klinkhammer, Sonja Djudjaj, Uta Kunter, Runólfur Pálsson, Viðar Ö. Eðvarðsson , et al. · 2020

Significance Statement Lack of well characterized experimental models of 2,8-dihydroxyadenine nephropathy—resulting from formation of 2,8-dihydroxyadenine crystals within renal tubules due to a rare hereditary deficiency of adenine phospho…

A guide to crystal‐related and nano‐ or microparticle‐related tissue responses Open

Shrikant R. Mulay, Stefanie Steiger, Chongxu Shi, Hans‐Joachim Anders · 2019

Crystals and nano‐ and microparticles form inside the human body from intrinsic proteins, minerals, or metabolites or enter the body as particulate matter from occupational and environmental sources. Associated tissue injuries and diseases…

Proteasome activator PA200 regulates myofibroblast differentiation Open

Vanessa Welk, Thomas Meul, Christina Lukas, Ilona Kammerl, Shrikant R. Mulay , et al. · 2019

The proteasome is essential for the selective degradation of most cellular proteins and is fine-tuned according to cellular needs. Proteasome activators serve as building blocks to adjust protein turnover in cell growth and differentiation…

Mitochondria Permeability Transition versus Necroptosis in Oxalate-Induced AKI Open

Shrikant R. Mulay, Mohsen Honarpisheh, Orestes Foresto‐Neto, Chongxu Shi, Jyaysi Desai , et al. · 2019

Significance Statement Sudden increases in serum oxalate levels occurring with certain dietary exposures or ethylene glycol poisoning are a well known cause of AKI. The authors recently reported that intrarenal precipitation of calcium oxa…

Editorial: Nano- and Microparticle-Induced Cell Death, Inflammation and Immune Responses Open

Shrikant R. Mulay, Martin Herrmann, Rostyslav Bilyy, Gabibov Alexander, Hans‐Joachim Anders · 2019

EDITORIAL article Front. Immunol., 17 April 2019Sec. Inflammation Volume 10 - 2019 | https://doi.org/10.3389/fimmu.2019.00844

Multifactorial functions of the inflammasome component NLRP3 in pathogenesis of chronic kidney diseases Open

Shrikant R. Mulay · 2019

CXCL12 blockade preferentially regenerates lost podocytes in cortical nephrons by targeting an intrinsic podocyte-progenitor feedback mechanism Open

Simone Romoli, Maria Lucia Angelotti, Giulia Antonelli, Santhosh V. Kumar, Shrikant R. Mulay , et al. · 2018

The Long Pentraxin PTX3 Is an Endogenous Inhibitor of Hyperoxaluria-Related Nephrocalcinosis and Chronic Kidney Disease Open

Julian A. Marschner, Shrikant R. Mulay, Stefanie Steiger, Lidia Anguiano, Zhi Zhao , et al. · 2018

The long pentraxin 3 (PTX3) exerts a variety of regulatory functions in acute and chronic tissue inflammation. In particular, PTX3 acts as an opsonin for a variety of pathogens and endogenous particles. We hypothesized that PTX3 would exhi…

Genetic mitochondrial glycine amidinotransferase protein aggregate formation triggers microparticle sensing and kidney failure Open

Shrikant R. Mulay, Hans‐Joachim Anders · 2018

Deposition of crystals or crystalline particles in various organs leads to diverse medical disorders (1). Misfolded or aggregated proteins can form crystalline or non-crystalline microparticles that activate similar molecular pathways of i…

IL-22 sustains epithelial integrity in progressive kidney remodeling and fibrosis Open

Marc Weidenbusch, Shangqing Song, Takamasa Iwakura, Chongxu Shi, Severin Rodler , et al. · 2018

IL-22, a member of the IL-10 cytokine family, accelerates tubule regeneration upon acute kidney injury, hence we speculated on a protective role also in chronic kidney disease. We quantified intrarenal IL-22 expression after unilateral ure…

Activated platelets induce MLKL-driven neutrophil necroptosis and release of neutrophil extracellular traps in venous thrombosis Open

Daigo Nakazawa, Jyaysi Desai, Stefanie Steiger, Susanne Müller, Satish Kumar Devarapu , et al. · 2018

Venous thromboembolic (VTE) disease, often manifesting as deep vein thrombosis or pulmonary embolism, involves clot formation consisting of blood cells and platelets locked in plasma protein and chromatin networks. The latter derives from …

COMPARATIVE EVALUATION OF THE AXIS MODIFICATION, CENTERING ABILITY AND APICAL DEBRIS EXTRUSION USING SINGLE-FILE RECIPROCATING AND CONTINUOUS ROTARY INSTRUMENTATION SYSTEMS IN CURVED ROOT CANALS– IN VITRO STUDY. Open

Tanvi Satpute, Shrikant R. Mulay · 2018

22May 2018 COMPARATIVE EVALUATION OF THE AXIS MODIFICATION, CENTERING ABILITY AND APICAL DEBRIS EXTRUSION USING SINGLE-FILE RECIPROCATING AND CONTINUOUS ROTARY INSTRUMENTATION SYSTEMS IN CURVED ROOT CANALS IN VITRO STUDY. Tanvi Satpute and…

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