Santanu Mukherjee
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View article: Alkylative Desymmetrization as Symmetry-Inspired Unified Strategy for the Enantioselective Synthesis of (–)-[5]-Ladderanoic Acid and Unnatural Inverse-[3]-ladderanol
Alkylative Desymmetrization as Symmetry-Inspired Unified Strategy for the Enantioselective Synthesis of (–)-[5]-Ladderanoic Acid and Unnatural Inverse-[3]-ladderanol Open
The unique architecture of naturally occurring ladderane phospholipids has inspired innovation in strategies for their chemical synthesis. Despite the emergence of a few independent synthetic routes to both their known components, i.e., (+…
View article: Catalytic Enantioselective α-Allenylation of Acetonitrile
Catalytic Enantioselective α-Allenylation of Acetonitrile Open
The widespread occurrence of the cyanomethyl group in bioactive molecules and natural products has triggered the development of efficient methods for its incorporation. Functionalization through the direct use of acetonitrile as C2 synthon…
View article: Sustainable management of post-phytoremediation biomass
Sustainable management of post-phytoremediation biomass Open
Organic and inorganic contaminants are entrained into environmental systems through natural and anthropogenic processes, such as mining activities, manufacturing, and waste disposal. In terrestrial and aquatic environments, the contaminant…
View article: The quorum-sensing lexicon of <i>Salmonella</i> ameliorates acid stress in the host by a non-canonical mechanism
The quorum-sensing lexicon of <i>Salmonella</i> ameliorates acid stress in the host by a non-canonical mechanism Open
The intestinal milieu is largely characterized by the complex array of chemical compounds produced through the metabolic activity of resident microbiota. Enteric pathogens like Salmonella , which have evolved refined mechanisms to persist …
View article: Enantioselective Redox-Neutral Coupling of Allenylic Alcohols through Divergent Cooperative Catalysis
Enantioselective Redox-Neutral Coupling of Allenylic Alcohols through Divergent Cooperative Catalysis Open
The past two decades have witnessed a magnificent growth of cooperative catalysis, where two substrates usually of complimentary polarity are activated independently by two different catalysts, before the reactive intermediates converge in…
View article: Enantioselective homocoupling of allenylic alcohols through divergent cooperative catalysis
Enantioselective homocoupling of allenylic alcohols through divergent cooperative catalysis Open
An enantioselective homocoupling of branched allenylic alcohols is developed under cooperative iridium and Lewis acid catalysis. In this reaction, racemic allenylic alcohol is transformed, under Lewis acidic Sc(OTf)3, into an...
View article: Correction: Hydroxy-directed iridium-catalyzed enantioselective formal β-C(sp<sup>2</sup>)–H allylic alkylation of α,β-unsaturated carbonyls
Correction: Hydroxy-directed iridium-catalyzed enantioselective formal β-C(sp<sup>2</sup>)–H allylic alkylation of α,β-unsaturated carbonyls Open
Correction for ‘Hydroxy-directed iridium-catalyzed enantioselective formal β-C(sp 2 )–H allylic alkylation of α,β-unsaturated carbonyls’ by Sankash Mitra et al. , Chem. Sci. , 2022, 13 , 12491–12497, https://doi.org/10.1039/D2SC03966D.
View article: Iridium Catalyzed Enantioselective C3 Allenylation of Pyridines
Iridium Catalyzed Enantioselective C3 Allenylation of Pyridines Open
An enantioselective C3-allenylation of pyridines has been developed through the intermediacy of oxazino pyridines. This dearomatization/electrophilic substitution/rearomatization strategy leverages the nucleophilicity of oxazino pyridines,…
View article: Iridium-Catalyzed Enantioselective Vinylogous and Bisvinylogous Allenylic Substitution
Iridium-Catalyzed Enantioselective Vinylogous and Bisvinylogous Allenylic Substitution Open
Compared to the widely explored enol silanes, the applicability of their extended variants especially as bisvinylogous nucleophiles in enantioselective catalysis has been sparse. Herein, we describe the first enantioselective vinylogous an…
View article: Catalytic Enantioselective Friedel–Crafts Allenylation
Catalytic Enantioselective Friedel–Crafts Allenylation Open
The first enantioselective Friedel‐Crafts (FC) allenylation reaction for the creation of central chirality is developed under cooperative Ir(I)/(phosphoramidite,olefin) and Lewis acid catalysis. This enantioconvergent reaction utilizes rac…
View article: Phosphorus Fraction in Hydrochar from Co-Hydrothermal Carbonization of Swine Manure and Rice Straw: An Optimization Analysis Based on Response Surface Methodology
Phosphorus Fraction in Hydrochar from Co-Hydrothermal Carbonization of Swine Manure and Rice Straw: An Optimization Analysis Based on Response Surface Methodology Open
Livestock manure and crop residues are significant sources of phosphorus. However, the ineffectiveness of current processing technologies often leads to the suboptimal recovery of this phosphorus, causing considerable resource wastage and …
View article: Iridium-Catalyzed Enantioselective Vinylogous and Bisvinylogous Allenylic Substitution
Iridium-Catalyzed Enantioselective Vinylogous and Bisvinylogous Allenylic Substitution Open
Compared to the widely explored enol silanes, applicability of their extended variants especially as bisvinylogous nucleophile in enantioselective catalysis has been sparse. Herein, we describe the first enantioselective vinylogous and bis…
View article: Catalytic Enantioselective Friedel-Crafts Allenylic Alkylation
Catalytic Enantioselective Friedel-Crafts Allenylic Alkylation Open
The first catalytic enantioselective Friedel-Crafts (FC) allenylic alkylation for the creation of central chirality has been developed under cooperative Ir(I)/(phosphoramidite,olefin) and Lewis acid catalysis. Using racemic allenylic alcoh…
View article: Ligand-Controlled Diastereodivergency in Propargylic Alkylation of Vinylogous Aza-enamine: Construction of 1,3-Stereocenters
Ligand-Controlled Diastereodivergency in Propargylic Alkylation of Vinylogous Aza-enamine: Construction of 1,3-Stereocenters Open
The first diastereodivergent propargylic alkylation reaction has been developed. This Cu(I)-catalyzed formal decarboxylative [4+2]-cycloaddition between ethynyl benzoxazinanone and vinylogous aza-enamine delivers tetrahydroquinoline deriva…
View article: Iridium-Catalyzed Enantioselective Formal α-Allylic Alkylation of Acrylonitrile
Iridium-Catalyzed Enantioselective Formal α-Allylic Alkylation of Acrylonitrile Open
A highly enantioselective formal α-allylic alkylation of acrylonitrile is developed using 4-cyano-3-oxotetrahydrothiophene (c-THT) as a safe and easy-to-handle surrogate of acrylonitrile. This two-step process consists of an Ir/(P,olefin)-…
View article: Centrally Chiral Arenes: From Concept to Catalytic Enantioselective Synthesis
Centrally Chiral Arenes: From Concept to Catalytic Enantioselective Synthesis Open
Compared to the well-established axial, planar, and helically chiral arenes, central chirality in arene derivatives arising out of unsymmetrically substituted arene rings is a relatively underexplored research topic. However, this counteri…
View article: Cluster Preface: Chemical Synthesis and Catalysis in India
Cluster Preface: Chemical Synthesis and Catalysis in India Open
Debabrata Maiti (left) received his Ph.D. from Johns Hopkins University in 2008 under the supervision of Prof. Kenneth D. Karlin. After postdoctoral studies at MIT with Prof. Stephen L. Buchwald, he joined the Department of Chemistry at II…
View article: Ubiquity and Exhaustion Doctrine: Ubiquity in Patents
Ubiquity and Exhaustion Doctrine: Ubiquity in Patents Open
The patent right allows the
View article: Exhaustion and Competition Policy: Patent Exhaustion and Its Relation with Competition Law and Policy
Exhaustion and Competition Policy: Patent Exhaustion and Its Relation with Competition Law and Policy Open
Competition Law and Policy in the Multilateral Trading SystemHistorically, evolution of 'ipr protection' as a discipline of law and 'Competi tion law' as a domain for regulating market competition have been separate and independent of each…
View article: Contents list
Contents list Open
Permissions Request permissions Contents list Org. Biomol. Chem., 2023, 21, 9291 DOI: 10.1039/D3OB90173D This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other pu…
View article: Mechanism and Origin of Remote Stereocontrol in the Organocatalytic Enantioselective Formal C(sp <sup>2</sup> )–H Alkylation Using Nitroalkanes as Alkylating Agents
Mechanism and Origin of Remote Stereocontrol in the Organocatalytic Enantioselective Formal C(sp <sup>2</sup> )–H Alkylation Using Nitroalkanes as Alkylating Agents Open
Experimental 13C kinetic isotope effects (KIEs) and density functional theory (DFT) calculations are used to evaluate the mechanism and origin of enantioselectivity in the formal C(sp2)-H alkylative desymmetrization of cyclopentene-1,3-dio…
View article: Enantioselective Synthesis of Skipped Dienes via Iridium-Catalyzed Allylic Alkylation of Phosphonate Carbanions
Enantioselective Synthesis of Skipped Dienes via Iridium-Catalyzed Allylic Alkylation of Phosphonate Carbanions Open
An enantioselective synthesis of skipped diene has been developed based on an iridium-catalyzed allylic alkylation of phosphonate carbanions and Horner-Wadsworth-Emmons olefination. This two-step protocol benefits from the ease of accessib…
View article: Enantioselective Synthesis of [3]-Ladderanol through a Late-Stage Organocatalytic Desymmetrization
Enantioselective Synthesis of [3]-Ladderanol through a Late-Stage Organocatalytic Desymmetrization Open
Ladderane phospholipids, with their unusual ladder-like arrangement of fused cyclobutane rings, represent an architecturally unique class of natural products. However, despite their fascinating structure and other necessary impetus, only a…
View article: Hydroxy-directed iridium-catalyzed enantioselective formal β-C(sp<sup>2</sup>)–H allylic alkylation of α,β-unsaturated carbonyls
Hydroxy-directed iridium-catalyzed enantioselective formal β-C(sp<sup>2</sup>)–H allylic alkylation of α,β-unsaturated carbonyls Open
The first formal enantioselective β-C(sp 2 )–H allylic alkylation of α,β-unsaturated carbonyls is developed through hydroxy-directed reaction of α-hydroxy enones with racemic branched allylic alcohols under cooperative Ir( i ) and Lewis ac…
View article: Polymeric Materials for Hemostatic Wound Healing
Polymeric Materials for Hemostatic Wound Healing Open
Hemorrhage is one of the greatest threats to life on the battlefield, accounting for 50% of total deaths. Nearly 86% of combat deaths occur within the first 30 min after wounding. While external wound injuries can be treated mostly using v…
View article: Anion‐Binding Catalysis with Other Anions
Anion‐Binding Catalysis with Other Anions Open
Anion binding is a powerful strategy, especially for enantioselectively catalyzing reactions involving cationic intermediates. This chapter covers the catalytic reactions proceeding via the binding of less common anions such as cyanide, ox…
View article: Ir-Catalyzed Chemodivergent Allenylic Alkylation of Vinyl Az-ides: Highly Enantioselective Synthesis of α-Allenylic Amides and Ketones
Ir-Catalyzed Chemodivergent Allenylic Alkylation of Vinyl Az-ides: Highly Enantioselective Synthesis of α-Allenylic Amides and Ketones Open
Enantioselective allenylic alkylation reactions of unstabilized enolates have never been reported. We now present a unified fragment-coupling strategy for the first enantioselective synthesis of α-allenylic amides and ketones through allen…