Explanipedia

The promise and perils of humanized mice: workshop report from the 29th scientific conference of the society on NeuroImmune pharmacology (SNIP) Open

Paul W. Denton, Ramesh Akkina, Howard E. Gendelman, Jennifer E. Koblinski, Angela Wahl , et al. · 2025

On June 8, 2025, the 29th Scientific Conference of the Society on NeuroImmune Pharmacology (SNIP) hosted a workshop on the Creation, Care, and Translation of Humanized Mouse for HIV/AIDS Research . The workshop was convened by the society …

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision Open

Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla , et al. · 2025

Advancements in antiretroviral therapy (ART) enable those living with the human immunodeficiency virus type one (HIV‐1) to lead longer, healthier lives free from disease comorbidities. However, lifelong ART poses challenges. These include …

CEST MRI Affirms HIV-1-Associated Neurometabolic Impairments in a Humanized Mouse Model Open

Gabriel C. Gauthier, Micah Summerlin, Balasrinivasa R. Sajja, Mariano Uberti, Emma G. Foster , et al. · 2025

Abstract 2598 Modelling TET2-DNA Complex Formation Open

Santhi Gorantla, Saad Raza, Josh V. Vermaas · 2025

Diastolic Dysfunction with Vascular Deficits in HIV-1-Infected Female Humanized Mice Treated with Antiretroviral Drugs Open

Fadhel A. Alomar, Prasanta K. Dash, Ramasamy Mahendran, Zachary L. Venn, Sean R. Bidasee , et al. · 2025

Early-onset heart failure is a major treat to healthy aging individuals with HIV-1 infection. Women with HIV-1 infection (WLWH) are especially vulnerable and develop heart failure with preserved ejection fraction (HFpEF), of which left ven…

Elevated Methylglyoxal: An Elusive Risk Factor Responsible for Early-Onset Cardiovascular Diseases in People Living with HIV-1 Infection Open

Ramasamy Mahendran, Zachary L. Venn, Fadhel A. Alomar, Ali Namvaran Abbas-Abad, Benson Edagwa , et al. · 2025

People living with HIV (PLWH) develop cardiovascular diseases (CVDs) about a decade earlier and at rates 2–3 times higher than the general population. At present, pharmacological strategies to delay the onset of CVDs in PLWH are unavailabl…

The 29th Scientific Conference of the Society on NeuroImmune Pharmacology in Omaha, NE, June 8–12, 2025 Open

Allison M. Andrews, Linda Chang, Rosemarie M. Booze, Sabita Roy, Santhi Gorantla , et al. · 2025

The 29 th Scientific Conference of the Society on Neuroimmune Pharmacology (SNIP) in Omaha, NE, will occur from June 8 th to 11 th , 2025. This four-day conference showcases world-renowned biomedical research, providing insights into the l…

HIV-1 infection facilitates Alzheimer’s disease pathology in humanized APP knock-in immunodeficient mice Open

Shaurav Bhattarai, Rana Kadry, Pravin Yeapuri, Yaman Lu, Emma G. Foster , et al. · 2025

Objectives Amyloid-β (Aβ) plaque deposition in the brain is a principal pathological feature of both Alzheimer’s disease (AD) and progressive human immunodeficiency virus type one (HIV-1) infection. Both enable Aβ assembly and Aβ protein a…

CCR5-ligand decorated rilpivirine lipid-based nanoparticles for sustained antiretroviral responses Open

Milankumar Patel, Sudipta Panja, Lubaba A. Zaman, Pravin Yeapuri, Shaurav Bhattarai , et al. · 2025

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV-1 Proviral DNA Excision Open

Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla , et al. · 2025

Single-cell profiling reveals a conserved role for hypoxia-inducible factor signaling during human craniotomy infection Open

Zachary Van Roy, Gunjan Kak, Lee E. Korshoj, Joseph Menousek, Cortney E. Heim , et al. · 2024

CCR5 Decorated Rilpivirine Lipid Nanoparticles Build Myeloid Drug Depots Which Sustains Antiretroviral Activities Open

Howard E. Gendelman, Milankumar Patel, Sudipta Panja, Lubaba A. Zaman, Pravin Yeapuri , et al. · 2024

Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation Open

Lauren A. Buck, Qiaowei Xie, Michelle Willis, Christine M Side, Laura L. Giacometti , et al. · 2024

Accelerated Neuroimmune Dysfunction in Aged HIV-1-Infected Humanized Mice Open

Chen Zhang, Hang Su, Emiko Waight, Larisa Y. Poluektova, Santhi Gorantla , et al. · 2024

Disordered immunity, aging, human immunodeficiency virus type one (HIV-1) infection, and responses to antiretroviral therapy are linked. However, how each factor is linked with the other(s) remains incompletely understood. It has been repo…

Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation Open

Jacqueline M. Barker, Lauren Buck, Qiaowei Xie, Michelle Willis, Christine M Side , et al. · 2023

Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation Open

Lauren A. Buck, Qiaowei Xie, Michelle Willis, Christine M Side, Laura L. Giacometti , et al. · 2023

Substance use disorders (SUDs) are highly comorbid with HIV infection, necessitating an understanding of the interactive effects of drug exposure and HIV. The relationship between progressive HIV infection and cocaine use disorder is likel…

Humanized Mice for Studies of HIV-1 Persistence and Elimination Open

Chen Zhang, Lubaba A. Zaman, Larisa Y. Poluektova, Santhi Gorantla, Howard E. Gendelman , et al. · 2023

A major roadblock to achieving a cure for human immunodeficiency virus type one (HIV-1) is the persistence of latent viral infections in the cells and tissue compartments of an infected human host. Latent HIV-1 proviral DNA persists in res…

The COVID-19 Pandemic: Reflections of Science, Person, and Challenge in Academic Research Settings Open

Jean M. Bidlack, Sulie L. Chang, Sylvia Fitting, H.E. Gendelman, Santhi Gorantla , et al. · 2023

In spring of 2021, the Society on NeuroImmune Pharmacology (SNIP) organized a virtual workshop on the coronavirus disease 2019 (COVID-19). The daylong event’s fourth and final symposium, “Well-being and reflections,” offered a glimpse at t…

CRISPR editing of CCR5 and HIV-1 facilitates viral elimination in antiretroviral drug-suppressed virus-infected humanized mice Open

Prasanta K. Dash, Chen Chen, Rafal Kaminski, Hang Su, Pietro Mancuso , et al. · 2023

Treatment of HIV-1 ADA -infected CD34+ NSG-humanized mice with long-acting ester prodrugs of cabotegravir, lamivudine, and abacavir in combination with native rilpivirine was followed by dual CRISPR-Cas9 C-C chemokine receptor type five (C…

Animal models for studies of HIV-1 brain reservoirs Open

Emiko Waight, Chen Zhang, Saumi Mathews, Bhavesh D. Kevadiya, K. C. Kent Lloyd , et al. · 2022

The HIV-1 often evades a robust antiretroviral-mediated immune response, leading to persistent infection within anatomically privileged sites including the CNS. Continuous low-level infection occurs in the presence of effective antiretrovi…

A Link Between Methylglyoxal and Heart Failure During HIV-1 Infection Open

Prasanta K. Dash, Fadhel A. Alomar, Jesse L. Cox, JoEllyn McMillan, Bryan T. Hackfort , et al. · 2021

Early-onset heart failure (HF) continues to be a major cause of morbidity and mortality in people living with human immunodeficiency virus type one (HIV-1) infection (PLWH), yet the molecular causes for this remain poorly understood. Herei…

The COVID-19 Pandemic: Reflections of Science, Person, and Challenge in Academic Research Settings Open

Jean M. Bidlack, Sulie L. Chang, Sylvia Fitting, Howard E. Gendelman, Santhi Gorantla , et al. · 2021

Editorial: Direct and Indirect Interactions of HIV With Host Cells Open

Tetsuo Tsukamoto, Santhi Gorantla, Vasco Rodrigues · 2021

HIV causes AIDS by infection and depletion of CD4 + T cells. HIV can also infect other CD4 + cells 12 such as macrophages, possibly leading to their functional alterations and contribution to viral reservoirs 13 (Hendricks et al., 2021). O…

Recovery of Latent HIV-1 from Brain Tissue by Adoptive Cell Transfer in Virally Suppressed Humanized Mice Open

Hang Su, Sruthi Sravanam, Brady Sillman, Emiko Waight, Edward Makarov , et al. · 2021

Humanized Mice for Infectious and Neurodegenerative disorders Open

Prasanta K. Dash, Santhi Gorantla, Larisa Y. Poluektova, Mahmudul Hasan, Emiko Waight , et al. · 2021

Humanized mice model human disease and as such are used commonly for research studies of infectious, degenerative and cancer disorders. Recent models also reflect hematopoiesis, natural immunity, neurobiology, and molecular pathways that i…

Human Microglia Extensively Reconstitute in Humanized-BLT Mice With Human Interleukin-34 Transgene and Support HIV-1 Brain Infection Open

Jianshui Zhang, Saroj Chandra Lohani, Yilun Cheng, Tao Wang, Lili Guo , et al. · 2021

Humanized bone marrow-liver-thymic (hu-BLT) mice develop a functional immune system in periphery, nevertheless, have a limited reconstitution of human myeloid cells, especially microglia, in CNS. Further, whether bone marrow derived hemato…

Human microglia extensively reconstitute in humanized BLT mice with human interleukin-34 transgene and support HIV-1 brain infection Open

Jianshui Zhang, Saroj Chandra Lohani, Yilun Cheng, Tao Wang, Lili Guo , et al. · 2021

Humanized bone marrow-liver-thymic (hu-BLT) mice develop a functional immune system in periphery but have a limited reconstitution of human myeloid cells, especially microglia, in CNS. Further, whether bone marrow derived hematopoietic ste…

Diagnostics for SARS-CoV-2 infections Open

Bhavesh D. Kevadiya, Jatin Machhi, Jonathan Herskovitz, Maxim Oleynikov, Wilson R. Blomberg , et al. · 2021

Efavirenz, atazanavir, and ritonavir disrupt sarcoplasmic reticulum Ca2+ homeostasis in skeletal muscles Open

Fadhel A. Alomar, Chengju Tian, Prasanta K. Dash, JoEllyn McMillan, Howard E. Gendelman , et al. · 2021

Pharmacotherapeutics of SARS-CoV-2 Infections Open

Bhavesh D. Kevadiya, Jatin Machhi, Jonathan Herskovitz, Maxim Oleynikov, Wilson R. Blomberg , et al. · 2021

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