Santhosh Kambaiah Nagaraj

Gut infection and dysbiosis are hallmarks of severe SARS-CoV-2 variants Open

Santhosh Kambaiah Nagaraj, Christy M. Joy, Rishad Shiraz, Rohan Narayan, Sumandeep Kaur , et al. · 2025

SARS-CoV-2, the virus behind the COVID-19 pandemic, is primarily a respiratory pathogen, with host entry mediated by the ACE2 receptor that determines viral tropism. Notably, in humans, ACE2 is highly expressed in the gastrointestinal (GI)…

SARS-CoV-2 Variants Exhibit Differential Gut Tropism and Dysbiosis in Syrian Golden Hamsters Open

Santhosh Kambaiah Nagaraj, Christy M. Joy, Rishad Shiraz, Rohan Narayan, Sumandeep Kaur , et al. · 2025

Mucosal SARS-CoV-2 vaccination of rodents elicits superior systemic T central memory function and cross-neutralising antibodies against variants of concern Open

Aled O’Neill, Chinmay Kumar Mantri, Chee Wah Tan, Wilfried A. A. Saron, Santhosh Kambaiah Nagaraj , et al. · 2023

This study was funded by Duke-NUS Medical School, the Singapore Ministry of Education, the National Medical Research Council of Singapore and a DBT-BIRAC Grant.

SARS-CoV-2 variants exhibit differential gut tropism and dysbiosis in Syrian golden hamsters Open

Santhosh Kambaiah Nagaraj, Christy M. Joy, Rishad Shiraz, Rohan Narayan, Sumandeep Kaur , et al. · 2023

Severe Acute Respiratory Syndrome Virus-2 (SARS-CoV-2) is a respiratory virus that uses angiotensin-converting enzyme 2 (ACE2) protein as an entry receptor. Thus, ACE2 expression levels in different tissues should dictate viral tropism. No…

A broadly protective CHO cell expressed recombinant spike protein subunit vaccine (IMT-CVAX) against SARS-CoV-2 Open

Jitender, B. Vikram Kumar, Sneha Singh, Geetika Verma, Reetesh Kumar , et al. · 2023

Protective immunity induced by COVID-19 vaccines is mediated mainly by spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we report the development of a recombinant prefusion stabilized SARS-CoV-2 spik…

Activity profiling of deubiquitinating inhibitors-bound to SARS-CoV-2 papain like protease with antiviral efficacy in murine infection model Open

Shweta Choudhary, Sanketkumar Nehul, Santhosh Kambaiah Nagaraj, Rohan Narayan, Shalja Verma , et al. · 2022

SARS-CoV-2 papain-like protease (PLpro) is a key antiviral target as it plays a dual role in viral replication and in modulation of innate immune responses by deubiquitinating or deISGylating host proteins. Thus, therapeutic targeting of P…

Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2 Open

Mohammad Afsar, Rohan Narayan, Md Noor Akhtar, Deepakash Das, Huma Rahil , et al. · 2022

The SARS-CoV-2 non-structural protein 1 (Nsp1) contains an N-terminal domain and C-terminal helices connected by a short linker region. The C-terminal helices of Nsp1 (Nsp1-C-ter) from SARS-CoV-2 bind in the mRNA entry channel of the 40S r…

Author response: Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2 Open

Mohammed Afsar, Rohan Narayan, Md Noor Akhtar, Deepakash Das, Huma Rahil , et al. · 2022

Scorpion Venom Exhibits Adjuvant Effect by Eliciting HBsAg-Specific Th1 Immunity Through Neuro-Endocrine Interactions Open

Santhosh Kambaiah Nagaraj, Dhatri Ramesh, D Rajasekar Ramesh, Urmila Nagaraj, S. Shrinidhi , et al. · 2021

Indian scorpions collected in Karnataka: maintenance in captivity, venom extraction and toxicity studies Open

Santhosh Kambaiah Nagaraj, Pavana Dattatreya, N. B. Thippeswamy · 2015

Scorpions were successfully maintained for 18 months. Herein we have also documented a simple, cost-effective method of venom extraction by electrical stimulation using a modified restrainer. Furthermore, Hottentotta rugiscutis was reporte…

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