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View article: 214 Metaplastic Breast Carcinoma with Spindle Cell and Squamous Differentiation Arising in a Phyllodes Tumor: A Rare and Complex Case
214 Metaplastic Breast Carcinoma with Spindle Cell and Squamous Differentiation Arising in a Phyllodes Tumor: A Rare and Complex Case Open
Introduction/Objective Metaplastic breast carcinoma (MBC) is a rare subtype of triple-negative breast cancer with both epithelial and mesenchymal features, comprising less than 1% of all breast malignancies. Even rarer is the occurrence of…
View article: Metformin toxicity in the intensive care unit: A case series and review of the literature
Metformin toxicity in the intensive care unit: A case series and review of the literature Open
Metformin toxicity is a life-threatening condition with high morbidity and mortality. Toxicity predominantly occurs in the setting of acute renal dysfunction, as the drug is solely eliminated by the kidneys. While this risk is widely known…
View article: Lymphoid Interstitial Pneumonia Associated With Hashimoto Thyroid Disease
Lymphoid Interstitial Pneumonia Associated With Hashimoto Thyroid Disease Open
Lymphoid interstitial pneumonia (LIP) refers to the diffuse infiltration and accumulation of lymphocytes within the alveolar interstitium and may be associated with multiple autoimmune diseases, most notably Sjögren syndrome. Only rare cas…
View article: Fatal hemorrhagic bronchopneumonia caused by Bordetella bronchiseptica in an immunocompetent patient
Fatal hemorrhagic bronchopneumonia caused by Bordetella bronchiseptica in an immunocompetent patient Open
Although macrolide antibiotics are first line treatment for B. pertussis and parapertussis, macrolide antibiotics are generally not effective against B. bronchiseptica. Clinical suspicion of B. bronchiseptica infection should prompt consid…
View article: Refractory pancytopenia upon initiation of asciminib in tyrosine kinase inhibitor-resistant chronic myeloid leukemia
Refractory pancytopenia upon initiation of asciminib in tyrosine kinase inhibitor-resistant chronic myeloid leukemia Open
Asciminib, a “Specifically Targeting the ABL Myristoyl Pocket” inhibitor, is a new drug in the treatment of tyrosine kinase inhibitor (TKI)-resistant chronic myeloid leukemia (CML). Hemocytopenias associated with asciminib are common adver…
View article: Prolidase deficiency: A novel <scp><i>PEPD</i></scp> missense variant in exon 2
Prolidase deficiency: A novel <span><i>PEPD</i></span> missense variant in exon 2 Open
Prolidase deficiency is an autosomal recessive disease that causes impaired collagen degradation. Altered collagen homeostasis results in the intracellular accumulation of imidodipeptides, which contain proline and hydroxyproline. The many…
View article: Selective <scp>IgG2</scp>‐deficiency in yellow nail syndrome
Selective <span>IgG2</span>‐deficiency in yellow nail syndrome Open
Key message IgG2 ‐deficiency increases susceptibility to recurrent pulmonary infections and the risk for bronchiectasis. Isolated IgG2 ‐deficiency has not been previously described in Yellow Nail Syndrome ( YNS ).
View article: Differential Diagnosis of Multiple Systemic Aneurysms
Differential Diagnosis of Multiple Systemic Aneurysms Open
Atherosclerosis and systemic hypertension are the most common pathogeneses of solitary acquired arterial aneurysms. The rare occurrence of multiple synchronous or metachronous arterial aneurysms requires considering alternative underlying …
View article: Massive empyema due to Lactococcus garvieae
Massive empyema due to Lactococcus garvieae Open
Heretofore unreported, this case demonstrates that L. garvieae can cause bronchopneumonia and empyema.
View article: Gastrointestinal histopathology of acute colchicine toxicity after lower dose treatment of pericarditis
Gastrointestinal histopathology of acute colchicine toxicity after lower dose treatment of pericarditis Open
Colchicine is an anti-inflammatory alkaloid drug with anti-microtubule activity. Colchicine toxicity is a serious and potentially fatal complication associated with hallmark histopathological features most conspicuous in proliferative tiss…
View article: Anti-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (Anti-HMG CoA) Myopathy With Cardiac Involvement: Presentation, Diagnosis, and Management
Anti-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (Anti-HMG CoA) Myopathy With Cardiac Involvement: Presentation, Diagnosis, and Management Open
Immune-mediated necrotizing myopathy (IMNM) is categorized into three groups: anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) IMNM, anti-signal recognition particle (SRP) IMNM, and seronegative IMNM. Cardiac involvement has be…
View article: Native valve emphysematous enterococcal endocarditis: expanding the differential diagnosis
Native valve emphysematous enterococcal endocarditis: expanding the differential diagnosis Open
E. faecalis-associated emphysematous endocarditis should be included in the differential diagnosis of valvular vegetation in patients with a rapidly progressing clinical course. When possible, histopathological analysis should be used alon…
View article: Septic Embolism in Endocarditis: Anatomic and Pathophysiologic Considerations
Septic Embolism in Endocarditis: Anatomic and Pathophysiologic Considerations Open
Septic embolism is a relatively common and potentially severe complication of infective endocarditis (IE). Septic emboli (SE), most often described as consisting of a combination of thrombus and infectious material—either bacterial or fung…
View article: Pheochromocytoma and stress cardiomyopathy: Insight into pathogenesis
Pheochromocytoma and stress cardiomyopathy: Insight into pathogenesis Open
This study adds to the growing body of literature on the predilection of patients with pheochromocytomas to develop non-ischemic CMP. Degree of catecholamine excess as measured by urinary secretion of metabolites did not predict the develo…