Santosh A. Misal
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View article: Identification of Plasmodium falciparum VAR2CSA peptides differentially recognized by IgG of multigravidae through epitope excision
Identification of Plasmodium falciparum VAR2CSA peptides differentially recognized by IgG of multigravidae through epitope excision Open
Background Placental malaria is associated with adverse outcomes for both mothers and their newborn children. During pregnancy, Plasmodium falciparum –infected erythrocytes (IEs) that surface-express VAR2CSA can bind chondroitin sulfate (C…
View article: TDP-43-stratified single-cell proteomic profiling of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis
TDP-43-stratified single-cell proteomic profiling of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis Open
Summary Unbiased proteomics has been employed to interrogate central nervous system (CNS) tissues (brain, spinal cord) and fluid matrices (CSF, plasma) from amyotrophic lateral sclerosis (ALS) patients; yet, a limitation of conventional bu…
View article: Non-Specific Signal Peptidase Processing of Extracellular Proteins in Staphylococcus aureus N315
Non-Specific Signal Peptidase Processing of Extracellular Proteins in Staphylococcus aureus N315 Open
Staphylococcus aureus is one of the major community-acquired human pathogens, with growing multidrug-resistance, leading to a major threat of more prevalent infections to humans. A variety of virulence factors and toxic proteins are secret…
View article: Conformational flexibility, lipid binding, and regulatory domains in CelTOS
Conformational flexibility, lipid binding, and regulatory domains in CelTOS Open
CelTOS is an essential Plasmodium traversal protein and conserved in apicomplexan parasites. We showed that CelTOS forms pores in cell membranes to enable traversal of parasites through cells (Jimah et al., 2016). Here, we establish roles …
View article: Ultrasensitive single-cell proteomics workflow identifies >1000 protein groups per mammalian cell
Ultrasensitive single-cell proteomics workflow identifies >1000 protein groups per mammalian cell Open
We report on the combination of nanodroplet sample preparation, ultra-low-flow nanoLC, high-field asymmetric ion mobility spectrometry (FAIMS), and the latest-generation Orbitrap Eclipse Tribrid mass spectrometer for greatly improved singl…
View article: Azoreductase: a key player of xenobiotic metabolism
Azoreductase: a key player of xenobiotic metabolism Open
View article: Biotransformation of Nitro Aromatic Compounds by Flavin-Free NADHAzoreductase
Biotransformation of Nitro Aromatic Compounds by Flavin-Free NADHAzoreductase Open
Nitro aromatic compounds are the potential toxic organic pollutant released into the environment and are often resistant to degradation under normal environmental conditions. The biotransformation and/or detoxification of these compounds c…