Explanipedia

Tributyltin chloride alters the structural, genomic, and epigenomic integrity of postejaculatory mammalian sperm Open

Muhammad Siddique, Santosh Anand, Marie‐Pierre L. Gauthier, Jason O. Brant, Michael P. Kladde , et al. · 2025

A global priority for ameliorating male factor infertility includes identification of environmental factors and mechanisms that impact sperm function. Detection of endocrine disrupting chemicals (EDC) in seminal plasma and within the femal…

In vitro Propagation of Medicinal and Aromatic Plants Open

Hemavathi Brijesh, Renuka Madhu, Brijesh Ajjappala, Ramya Manjunath, Santosh Anand · 2025

Methods Used in Gene Identification, Localization, and Sequencing Open

Ram Baran Singh, Ramachandra Ramanjinappa, Santosh Anand · 2025

Cellular and Transcriptional Responses of Human Bronchial Epithelial Cells to Delta-9-Tetrahydrocannabinol In Vitro Open

Megan S. Doldron, Sourav Chakraborty, Santosh Anand, Mehwish Faheem, Beh Reh , et al. · 2025

Delta-9-tetrahydrocannabinol (Δ-9-THC or THC), the primary psychoactive constituent of cannabis, can lead to adverse health conditions, including mental health issues, brain impairment, and cardiac and respiratory problems. The amount of T…

Precision with semi-precision attachment using CAD/CAM technology for a mandibulectomy patient: A case report Open

Preeti Thakur, Annie Cleetus, Irfanul Huda, Santosh Anand, Mohan Kadao · 2025

Rehabilitation of mandibular defects post-marginal mandibulectomy presents significant challenges due to altered anatomy, reduced denture-bearing areas, and compromised muscle attachments that affect tongue mobility, speech, and masticatio…

Management of hemi-mandibulectomy patient with prosthetic devices Open

Richa Richa, Varsha Pathiyil, Irfanul Huda, Santosh Anand, Annie Cleetus · 2023

The success in rehabilitating a patient with hemi-mandibulectomy depends upon the nature and extent of the surgical defect, treatment plan, type of prosthesis, and patient co-operation. The management becomes more challenging when the pros…

CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival Open

Silje Lier, Solveig Osnes Lund, Anuja Lipsa, Katrin Frauenknecht, Idun Dale Rein , et al. · 2023

Glioblastoma is the most prevalent and aggressive malignant tumor of the central nervous system. With a median overall survival of only one year, glioblastoma patients have a particularly poor prognosis, highlighting a clear need for novel…

Knowledge, attitude, and perception of dental undergraduates towards mobile and digital learning methods in India: A cross-sectional study Open

Anshu Prakash, Amit Kumar, Amit Kumar, Ritesh Raj, Santosh Anand , et al. · 2023

BACKGROUND: Internet-based education is having few advantages since it increases an emphasis on the education system based on problems by incorporation of both visual as well as interactive tools. Also, some contributions to practical skil…

Effects of Yoga therapy in teaching oral hygiene practice and tooth brushing skills in patients with Parkinson's disease: A qualitative study Open

Ritesh Raj, Abhishek Verma, Rohit Kumar Singh, Amit Kumar, Anshu Prakash , et al. · 2023

BACKGROUND: Parkinson's disease is a chronic neurodegenerative disorder associated with heterogeneous symptoms. Though it is characterized by means of four distinct motor symptoms such as resting tremors, muscular rigidity, bradykinesia, a…

Development of Petro-Electric Vehicle Open

Mahesh L Mahesh L, Santosh Anand, H Nagishetty Chandrakanth, H. R. Sudarshan Reddy, M. Karthik · 2023

The exhaust of fossil fuels has made to think on alternative energy utilization like electrical energy. The automobile sector is one where one can replace the requirement of fossil fuels by electrical energy. Almost all researchers and dev…

The emerging role of PI3K inhibitors for solid tumour treatment and beyond Open

Carmen Belli, Matteo Repetto, Santosh Anand, Camillo Porta, Vivek Subbiah , et al. · 2023

Accurate and fast clade assignment via deep learning and frequency chaos game representation Open

Jorge Avila Cartes, Santosh Anand, Simone Ciccolella, Paola Bonizzoni, Gianluca Della Vedova · 2022

Background Since the beginning of the coronavirus disease 2019 pandemic, there has been an explosion of sequencing of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, making it the most widely sequenced virus in the …

P10.12.A CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival Open

Silje Lier, Idun Dale Rein, Solveig Osnes Lund, Anna Lång, Emma Lång , et al. · 2022

Background Glioblastoma multiforme (GBM) is the most prevalent and aggressive malignant tumor of the central nervous system. With a median survival of only one year, GBM patients have a particularly poor prognosis, highlighting a clear nee…

Correction to: A multi-step genomic approach prioritized TBKBP1 gene as relevant for multiple sclerosis susceptibility Open

Melissa Sorosina, Nadia Barizzone, Ferdinando Clarelli, Santosh Anand, Sara Lupoli , et al. · 2022

Accurate and Fast Clade Assignment via Deep Learning and Frequency Chaos Game Representation Open

Jorge Avila Cartes, Santosh Anand, Simone Ciccolella, Paola Bonizzoni, Gianluca Della Vedova · 2022

Background Since the beginning of the COVID-19 pandemic there has been an explosion of sequencing of the SARS-CoV-2 virus, making it the most widely sequenced virus in the history. Several databases and tools have been created to keep trac…

A multi-step genomic approach prioritized TBKBP1 gene as relevant for multiple sclerosis susceptibility Open

Melissa Sorosina, Nadia Barizzone, Ferdinando Clarelli, Santosh Anand, Sara Lupoli , et al. · 2022

Background Over 200 genetic loci have been associated with multiple sclerosis (MS) explaining ~ 50% of its heritability, suggesting that additional mechanisms may account for the “missing heritability” phenomenon. Objective To analyze a la…

Accurate classification of SARS-CoV-2 clades using Frequency Chaos Game Representation Open

Jorge Avila Cartes, Santosh Anand, Simone Ciccolella, Paola Bonizzoni, Gianluca Della Vedova · 2022

Results and trained models that are reported in the paper for different k-mers (k=6,7,8,9). It contains: - list of train, validation and test sets used for the experiments - plots for accuracy, validation and confusion matrices. - saliency…

Accurate classification of SARS-CoV-2 clades using Frequency Chaos Game Representation Open

Jorge Avila Cartes, Santosh Anand, Simone Ciccolella, Paola Bonizzoni, Gianluca Della Vedova · 2022

Results and trained models that are reported in the paper for different k-mers (k=6,7,8). It contains: - list of train, validation, and test sets used for the experiments - best weights for each trained model in a 5Repeated Fold cross-vali…

Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis Open

Sampath Kumar Katakam, Santosh Anand, Patricia Martin, Nicolò Riggi, Ivan Stamenkovic · 2022

Malignant tumors commonly display necrosis, which invariably triggers an inflammatory response that supports tumor growth. However, the effect on tumor cells of necrotic debris, or damage-associated molecular patterns (DAMPs) released by d…

Contribution of Rare and Low-Frequency Variants to Multiple Sclerosis Susceptibility in the Italian Continental Population Open

Ferdinando Clarelli, Nadia Barizzone, Eleonora Mangano, Miriam Zuccalà, Chiara Basagni , et al. · 2022

Genome-wide association studies identified over 200 risk loci for multiple sclerosis (MS) focusing on common variants, which account for about 50% of disease heritability. The goal of this study was to investigate whether low-frequency and…

Assessment of Oral Health Status with Visually Impaired Children in Patna City, Bihar Open

Santosh Anand, Kumari Kavita, Amresh Pandey, Shilpi Verma, Revati Singh , et al. · 2021

Aim: Children with a visually impairment often face various challenges in their day-to-day skills. Oral hygiene maintenance is one major task for them. Such child has difficulty to live current normal life and demands of permission or heal…

High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites Open

Ludovica Vanzan, Hadrien Soldati, Victor Ythier, Santosh Anand, Simon M. G. Braun , et al. · 2021

Efficacy of Transdermal Diclofenac Patch and Ketoprofen Patch as Postoperative Analgesia after Extraction of First Premolars Bilaterally in Both Arches for Orthodontic Purpose: A Comparative Study Open

Daya Shankar, Abhishek Sinha, Santosh Anand, Neeraj Verma, Shivendra Choudhary · 2021

Aim: The aim of the study was to compare the efficacy of transdermal diclofenac patch with ketoprofen patch as postoperative analgesia after extraction of first premolars bilaterally in both arches for orthodontic purpose. Materials and Me…

Comparative Evaluation of Changes in Microflora in Delayed and Immediate Implant Placement: An In vivo Study Open

Shivendra Choudhary, Neeraj Verma, Santosh Anand, Abhishek Sinha, Daya Shankar · 2021

Aim: This study is aimed to compare and evaluate the changes in the microflora in immediate and delayed placed implants. Materials and Methods: In this study, the implant site sample was taken and assessed during different phases of treatm…

Antimicrobial resistance dynamics and the one-health strategy: a review Open

Kumar Siddharth Singh, Santosh Anand, Sunny Dholpuria, Jitendra Kumar Sharma, Wulf Blankenfeldt , et al. · 2021

Dermatoglyphics and Cheiloscopy patterns in hypertensive and type 2 Diabetes mellitus patients Open

Mouneshkumar CD, Santosh Anand, Shilpa RH, Nazia Haidry, Pranay Kulkarni , et al. · 2021

Background: Essential hypertension is a type of hypertension which bears no etiological reasons. It is found to affect approximately 90 to 95 percent of hypertensive individuals. Similarly, type 2 diabetes or diabetes mellitus is a genetic…

Functional Pro-metastatic Heterogeneity Revealed by Spiked-scRNAseq Is Shaped by Cancer Cell Interactions and Restricted by VSIG1 Open

Carolina Bernal-Morales, Marianna Silvano, Yann Tapponnier, Santosh Anand, Cecilia Angulo , et al. · 2020

How cells with metastatic potential, or pro-metastatic states, arise within heterogeneous primary tumors remains unclear. Here, we have used one index primary colon cancer to develop spiked-scRNAseq to link omics-defined single-cell cluste…

Development and Validation of a Serum Metabolomic Signature for Endometrial Cancer Screening in Postmenopausal Women Open

Jacopo Troisi, Antonio Raffone, Antonio Travaglino, Gaetano Belli, Carmen Belli , et al. · 2020

In this study, dried blood metabolomic profile was used to assess the presence or absence of EC in postmenopausal women not receiving hormonal therapy with greater than 99% accuracy.

Progresses Toward Precision Medicine in<i>RET</i>-altered Solid Tumors Open

Carmen Belli, Santosh Anand, Justin F. Gainor, Frédérique Penault‐Llorca, Vivek Subbiah , et al. · 2020

RET (rearranged during transfection) gene encodes a receptor tyrosine kinase essential for many physiologic functions, but RET aberrations are involved in many pathologies. While RET loss-of-function mutations are associated with congenita…

Author Correction: Next Generation Sequencing of Pooled Samples: Guideline for Variants’ Filtering Open

Santosh Anand, Eleonora Mangano, Nadia Barizzone, Roberta Bordoni, Melissa Sorosina , et al. · 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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