Santosh Kesari
YOU?
Author Swipe
View article: Evaluation of HLA Region-Specific High-Throughput Sequencing FASTQ Reads Combined with Ensemble HLA-Typing Tools for Rapid and High-Confidence HLA Typing
Evaluation of HLA Region-Specific High-Throughput Sequencing FASTQ Reads Combined with Ensemble HLA-Typing Tools for Rapid and High-Confidence HLA Typing Open
Background: Accurate human leukocyte antigen (HLA) genotyping is a critical step in the implementation of neoantigen peptide-based cancer immunotherapy. Existing computational tools for HLA genotyping using high-throughput sequencing data …
View article: CTIM-23. FIRST-IN-HUMAN IMMUNOTHERAPY TARGETING LYMPHOPENIA IN RECURRENT GLIOBLASTOMA MULTIFORM (GBM): NAI AND PD-L1 T-HANK PLUS BEVACIZUMAB WITH COMPLETE RESPONSE
CTIM-23. FIRST-IN-HUMAN IMMUNOTHERAPY TARGETING LYMPHOPENIA IN RECURRENT GLIOBLASTOMA MULTIFORM (GBM): NAI AND PD-L1 T-HANK PLUS BEVACIZUMAB WITH COMPLETE RESPONSE Open
BACKGROUND Treatment options for recurrent GBM are limited and associated with high mortality. We hypothesize that current standards of care for GBM induce severe lymphopenia, and by treating lymphopenia (activating NK & T-cells, lymphocyt…
View article: CTNI-36. SINGLE INSTITUTE REPORT OF DORDAVIPRONE (ONC 201) PLUS BEVACIZUMAB COMBINATION THERAPY ON THE EXPANDED ACCESS PROTOCOL (ONC 028)
CTNI-36. SINGLE INSTITUTE REPORT OF DORDAVIPRONE (ONC 201) PLUS BEVACIZUMAB COMBINATION THERAPY ON THE EXPANDED ACCESS PROTOCOL (ONC 028) Open
BACKGROUND Dordaviprone (ONC201), an oral, CNS penetrant, targeted small molecule ClpP agonist and DRD2 antagonist, is currently under investigation in patients with H3K27M-mutant diffuse glioma. Expanded access programs (EAPs) have offere…
View article: INNV-29. Clinical and imaging response to ivosidenib for progressive isocitrate dehydrogenase-1 (IDH-1) mutated clival chordoma
INNV-29. Clinical and imaging response to ivosidenib for progressive isocitrate dehydrogenase-1 (IDH-1) mutated clival chordoma Open
BACKGROUND Chordoma is a rare but aggressive malignant tumor that occurs in the skull base and spine. Currently, there are no FDA approved drug therapies to treat chordoma. Tissue molecular profile testing may help illuminate potential tar…
View article: Comparing the performance of DSC and ASL for Detecting Residual and Recurrent Glioblastoma with Deep Learning and multishell diffusion MRI
Comparing the performance of DSC and ASL for Detecting Residual and Recurrent Glioblastoma with Deep Learning and multishell diffusion MRI Open
Background Differentiating recurrent tumor from post-treatment changes remains a major challenge in glioblastoma (GBM) patients. In this work, we compared the performance of two different MR perfusion techniques, dynamic susceptibility con…
View article: Phase 2 trial of personal dendritic cell vaccines in newly diagnosed glioblastoma: 3-year follow-up and correlations with survival
Phase 2 trial of personal dendritic cell vaccines in newly diagnosed glioblastoma: 3-year follow-up and correlations with survival Open
Survival of glioblastoma (GBM) patients is unsatisfactory. Adding patient-specific vaccines to standard therapy may improve outcomes. Autologous dendritic cells (DC) loaded with autologous tumor antigens (ATA) from short-term cell lines es…
View article: 38 OLIG2 MEDIATES A RARE TARGETABLE STEM CELL FATE TRANSITION IN SONIC HEDGEHOG MEDULLOBLASTOMA
38 OLIG2 MEDIATES A RARE TARGETABLE STEM CELL FATE TRANSITION IN SONIC HEDGEHOG MEDULLOBLASTOMA Open
Functional cellular heterogeneity in tumours often underlies incomplete response to therapy and relapse. Previously, we demonstrated that the growth of the paediatric brain malignancy, sonic hedgehog subgroup medulloblastoma, is rooted in …
View article: Multimodal evaluation of cerebrospinal fluid from breast cancer leptomeningeal metastases using circulating tumor cell detection, single-cell sequencing, and proteomics
Multimodal evaluation of cerebrospinal fluid from breast cancer leptomeningeal metastases using circulating tumor cell detection, single-cell sequencing, and proteomics Open
These findings highlight the potential utility of molecular profiling of CSF as an early indicator of treatment response and an approach for identifying resistance mechanisms and optimal combination therapies.
View article: Assessment of Functional Status of Human Leukocyte Antigen Class I Genes in Cancer Tissues in the Context of Personalized Neoantigen Peptide Vaccine Immunotherapy
Assessment of Functional Status of Human Leukocyte Antigen Class I Genes in Cancer Tissues in the Context of Personalized Neoantigen Peptide Vaccine Immunotherapy Open
PURPOSE Accurate human leukocyte antigen (HLA) typing is an essential step for designing peptide vaccines used in the personalized neoantigen peptide vaccine immunotherapy (PNPVT) in patients with cancer. The reasons for variation in the p…
View article: 3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene Signatures
3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene Signatures Open
Glioblastoma (GBM) is a lethal brain cancer with no effective treatment; understanding how GBM cells respond to tumor microenvironment remains challenging as conventional cell cultures lack proper cytoarchitecture while in vivo animal mode…
View article: Editorial Expression of Concern: Safety of targeting tumor endothelial cell antigens
Editorial Expression of Concern: Safety of targeting tumor endothelial cell antigens Open
View article: Drug and Single-Cell Gene Expression Integration Identifies Sensitive and Resistant Glioblastoma Cell Populations
Drug and Single-Cell Gene Expression Integration Identifies Sensitive and Resistant Glioblastoma Cell Populations Open
Glioblastoma (GBM) remains the most common and lethal adult malignant primary brain cancer with few treatment options. A significant issue hindering GBM therapeutic development is intratumor heterogeneity. GBM tumors contain neoplastic cel…
View article: Development of a miRNA-based deep learning model for autism spectrum disorder diagnosis
Development of a miRNA-based deep learning model for autism spectrum disorder diagnosis Open
JOURNAL/atin/04.03/02274269-202506000-00002/figure1/v/2025-09-16T151948Z/r/image-tiff Autism spectrum disorder is a neurodevelopmental disorder characterized by differences in social behaviors, intellectual disabilities, and various mental…
View article: Characterization of pritumumab in murine models and primate safety study
Characterization of pritumumab in murine models and primate safety study Open
Pritumumab is a human IgG1 kappa antibody that targets ecto-domain vimentin (EDV) which is overexpressed in several malignant tumors including glioblastomas. To understand preclinical biological activity and safety of pritumumab derived fr…
View article: miRNA-Based Diagnosis of Schizophrenia Using Machine Learning
miRNA-Based Diagnosis of Schizophrenia Using Machine Learning Open
Diagnostic practices for schizophrenia are unreliable due to the lack of a stable biomarker. However, machine learning holds promise in aiding in the diagnosis of schizophrenia and other neurological disorders. Dysregulated miRNAs were ext…
View article: Inhibitors of soluble epoxide hydrolase and cGAS/STING repair defects in amyloid-β clearance underlying vascular complications of Alzheimer's disease
Inhibitors of soluble epoxide hydrolase and cGAS/STING repair defects in amyloid-β clearance underlying vascular complications of Alzheimer's disease Open
Background Alzheimer's disease (AD) and its monoclonal antibody therapies are associated with brain vasculitis and amyloid-related imaging abnormalities. The naturally-formed epoxides (EpFAs) of polyunsaturated fatty acids (PUFAs), such as…
View article: OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma
OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma Open
View article: Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179
Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179 Open
View article: miRNA biomarkers-based diagnosis of diffuse large B-cell lymphoma using machine learning
miRNA biomarkers-based diagnosis of diffuse large B-cell lymphoma using machine learning Open
View article: Phase II trial of nilotinib in PDGFR-alpha-enriched recurrent high-grade gliomas
Phase II trial of nilotinib in PDGFR-alpha-enriched recurrent high-grade gliomas Open
Background This phase II clinical trial evaluated the safety and efficacy of nilotinib in patients with recurrent, platelet-derived growth factor receptor alpha (PDGFRA)-enriched high-grade gliomas. Methods Thirty-four adult patients with …
View article: Autologous macrophages stimulated by epoxides of polyunsaturated fatty acids and protected by inhibitors of soluble epoxide hydrolase or cGAS/STING pathway repair amyloid‐β pathology in the Alzheimer’s disease (AD) brain
Autologous macrophages stimulated by epoxides of polyunsaturated fatty acids and protected by inhibitors of soluble epoxide hydrolase or cGAS/STING pathway repair amyloid‐β pathology in the Alzheimer’s disease (AD) brain Open
Background Brain accumulation of amyloid‐ß 1‐42 (Aß) in plaques and neurons is the cause of AD neuropathology that is opposed by autologous monocyte/macrophages (MMs) in health but this defense fails in AD. Method RNAseq, immunochemistry o…
View article: Mesenchymal stem cells - the secret agents of cancer immunotherapy: Promises, challenges, and surprising twists
Mesenchymal stem cells - the secret agents of cancer immunotherapy: Promises, challenges, and surprising twists Open
Mesenchymal stem cells (MSCs) are recognized for their immunomodulatory capabilities, tumor-homing abilities, and capacity to serve as carriers for therapeutic agents. This review delves into the role of adoptively transferred MSCs in tumo…
View article: Activity of pemetrexed in recurrent, metastatic sacral chordoma: A case report
Activity of pemetrexed in recurrent, metastatic sacral chordoma: A case report Open
Chordomas are a rare slow growing tumor with a high recurrence rate that originate from residual embryonic notochord cells, primarily affecting the axial skeleton. Currently limited treatment options exist beyond surgery and radiation, and…
View article: Pre-radiation Nivolumab plus ipilimumab in patients with newly diagnosed high-grade gliomas
Pre-radiation Nivolumab plus ipilimumab in patients with newly diagnosed high-grade gliomas Open
The limited success of immune checkpoint inhibitors (ICIs) in the adjuvant setting for glioblastoma highlights the need to explore administering ICIs prior to immunosuppressive radiation. To address the feasibility and safety of this appro…
View article: Low PD-L1 expression, MAP2K2 alterations, and enriched HPV gene signatures characterize brain metastases in head and neck squamous cell carcinoma
Low PD-L1 expression, MAP2K2 alterations, and enriched HPV gene signatures characterize brain metastases in head and neck squamous cell carcinoma Open
HNSCC patients with BM frequently have oropharyngeal primary sites and are HPV+. Common molecular alterations in BM samples, including targetable PIK3CA and ATM, were identified. MAP2K2 alterations were enriched and densities of immune cel…
View article: Biological and prognostic relevance of epigenetic regulatory genes in high-grade gliomas (HGGs)
Biological and prognostic relevance of epigenetic regulatory genes in high-grade gliomas (HGGs) Open
Background High-grade gliomas (HGGs) are the most aggressive type of gliomas and have the poorest outcomes. Chromatin remodeling (CR) genes have been implicated in multiple oncogenic pathways in numerous cancer types. In gliomagenesis, CR …
View article: A Health Care Clinical Data Platform for Rapid Deployment of Artificial Intelligence and Machine Learning Algorithms for Cancer Care and Oncology Clinical Trials
A Health Care Clinical Data Platform for Rapid Deployment of Artificial Intelligence and Machine Learning Algorithms for Cancer Care and Oncology Clinical Trials Open
The xCures platform aggregates, organizes, structures, and normalizes clinical EMR data across care sites, utilizing advanced technologies for near real-time access. The platform generates data in a format to support clinical care, acceler…
View article: piRNA in Machine-Learning-Based Diagnostics of Colorectal Cancer
piRNA in Machine-Learning-Based Diagnostics of Colorectal Cancer Open
Objective biomarkers are crucial for early diagnosis to promote treatment and raise survival rates for diseases. With the smallest non-coding RNAs—piwi-RNAs (piRNAs)—and their transcripts, we sought to identify if these piRNAs could be use…
View article: Mesenchymal Stromal Cell Implants for Chronic Motor Deficits After Traumatic Brain Injury
Mesenchymal Stromal Cell Implants for Chronic Motor Deficits After Traumatic Brain Injury Open
This study provides Class I evidence that intracranial implantation of allogeneic stem (SB623) cells in adults with motor deficits from chronic TBI improves motor function at 24 weeks.
View article: Deep Learning Segmentation of Infiltrative and Enhancing Cellular Tumor at Pre- and Posttreatment Multishell Diffusion MRI of Glioblastoma
Deep Learning Segmentation of Infiltrative and Enhancing Cellular Tumor at Pre- and Posttreatment Multishell Diffusion MRI of Glioblastoma Open
Purpose To develop and validate a deep learning (DL) method to detect and segment enhancing and nonenhancing cellular tumor on pre- and posttreatment MRI scans in patients with glioblastoma and to predict overall survival (OS) and progress…