Sanyou Chen
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View article: Quantum relaxometry for detecting biomolecular interactions with single NV centers
Quantum relaxometry for detecting biomolecular interactions with single NV centers Open
The investigation of biomolecular interactions at the single-molecule level has emerged as a pivotal research area in life science, particularly through optical, mechanical, and electrochemical approaches. Spins existing widely in biologic…
View article: In situ electron paramagnetic resonance spectroscopy using single nanodiamond sensors
In situ electron paramagnetic resonance spectroscopy using single nanodiamond sensors Open
An ultimate goal of electron paramagnetic resonance (EPR) spectroscopy is to analyze molecular dynamics in place where it occurs, such as in a living cell. The nanodiamond (ND) hosting nitrogen-vacancy (NV) centers will be a promising EPR …
View article: In situ electron paramagnetic resonance spectroscopy using single nanodiamond sensors
In situ electron paramagnetic resonance spectroscopy using single nanodiamond sensors Open
An ultimate goal of electron paramagnetic resonance (EPR) spectroscopy is to analyze molecular dynamics in place where it occurs, such as in a living cell. The nanodiamond (ND) hosting nitrogen-vacancy (NV) centers will be a promising EPR …
View article: Digital Magnetic Detection of Biomolecular Interactions with Single Nanoparticles
Digital Magnetic Detection of Biomolecular Interactions with Single Nanoparticles Open
Biomolecular interactions compose a fundamental element of all life forms and are the biological basis of many biomedical assays. However, current methods for detecting biomolecular interactions have limitations in sensitivity and specific…
View article: Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond
Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond Open
Significance Understanding cancer’s biomarker, microenvironment, and heterogeneity at the tissue level promises to improve cancer biology and clinical diagnosis and treatment. Many histological imaging techniques have been developed for th…
View article: Nanoscale magnetic resonance imaging of proteins in a single cell
Nanoscale magnetic resonance imaging of proteins in a single cell Open
Magnetic resonance imaging (MRI) is a non-invasive and label-free technique widely used in medical diagnosis and life science research, and its success has benefited greatly from continuing efforts on enhancing contrast and resolution. Her…
View article: Nanoscale magnetic imaging of ferritins in a single cell
Nanoscale magnetic imaging of ferritins in a single cell Open
A nitrogen-vacancy center in diamond is used for magnetic imaging of intracellular proteins in a single cell at 10-nm scale.
View article: A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity
A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity Open
KCNE β-subunits play critical roles in modulating cardiac voltage-gated potassium channels. Among them, KCNE1 associates with KCNQ1 channel to confer a slow-activated IKs current, while KCNE2 functions as a dominant negative modulator to s…