Sapan D. Gandhi
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View article: Local RANTES/CCL5 Delivery and Peripheral Blood Mobilization of Endogenous Marrow-Derived Mesenchymal Stem Cells to Mitigate Lumbar Intervertebral Disc Degeneration
Local RANTES/CCL5 Delivery and Peripheral Blood Mobilization of Endogenous Marrow-Derived Mesenchymal Stem Cells to Mitigate Lumbar Intervertebral Disc Degeneration Open
Study Design Translational rodent study. Objectives To investigate (1) chemokine-mediated mesenchymal stem cell mobilization and homing to the intervertebral disc and (2) using this technique to mitigate intervertebral disc degeneration in…
View article: Timing of Chemical Anticoagulant Administration in Spine Trauma and its Impact on VTE, Bleeding, and Mortality: A Systematic Review and Meta-Analysis
Timing of Chemical Anticoagulant Administration in Spine Trauma and its Impact on VTE, Bleeding, and Mortality: A Systematic Review and Meta-Analysis Open
Study Design Systematic review and meta-analysis. Objective To evaluate the timing of anticoagulation in acute spinal trauma, specifically assessing the efficacy and safety of early (<48 hours) vs delayed administration for chemical venous…
View article: Degenerative disc disease and isthmic spondylolisthesis have similar outcomes after L5-S1 anterior lumbar interbody fusion
Degenerative disc disease and isthmic spondylolisthesis have similar outcomes after L5-S1 anterior lumbar interbody fusion Open
Despite inferior preoperative and final postoperative scores, patients with DDD experienced similar clinical improvement and outcomes after L5-S1 ALIF compared to patients with IS. Moreover, DDD patients were equally likely as IS patients …
View article: Osteoblastoma of the frontal sinus: A rare case presenting with seizures and pneumocephalus
Osteoblastoma of the frontal sinus: A rare case presenting with seizures and pneumocephalus Open
Key Clinical Message Osteoblastoma of the frontal sinus, although rare, can manifest with seizures and pneumocephalus, underscoring the importance of thorough evaluation and complete surgical excision to prevent serious complications and e…
View article: The Effect of Changes in Segmental Lordosis on Global Lumbar and Adjacent Segment Lordosis After L5-S1 Anterior Lumbar Interbody Fusion
The Effect of Changes in Segmental Lordosis on Global Lumbar and Adjacent Segment Lordosis After L5-S1 Anterior Lumbar Interbody Fusion Open
Study Design Retrospective Cohort Study. Objective Restoration of lordosis in lumbar fusion reduces low back pain, decreases adjacent segment degeneration, and improves postoperative outcomes. However, the potential effects of changes in s…
View article: Prone transpsoas lumbar corpectomy: simultaneous posterior and lateral lumbar access for difficult clinical scenarios
Prone transpsoas lumbar corpectomy: simultaneous posterior and lateral lumbar access for difficult clinical scenarios Open
OBJECTIVE Lateral lumbar corpectomy with interbody fusion has been well described via a transpsoas approach in the lateral position, as has lumbar interbody fusion with posterior fixation in the prone position. However, no previous report …
View article: Factors Affecting the Decision to Initiate Anticoagulation After Spine Surgery: Findings From the AOSpine Anticoagulation Global Initiative
Factors Affecting the Decision to Initiate Anticoagulation After Spine Surgery: Findings From the AOSpine Anticoagulation Global Initiative Open
Study Design: Cross-sectional, international survey. Objectives: To identify factors influencing pharmacologic anticoagulation initiation after spine surgery based on the AOSpine Anticoagulation Global Survey. Methods: This survey was dist…
View article: Preoperative paraspinal neck muscle characteristics predict early onset adjacent segment degeneration in anterior cervical fusion patients: A machine‐learning modeling analysis
Preoperative paraspinal neck muscle characteristics predict early onset adjacent segment degeneration in anterior cervical fusion patients: A machine‐learning modeling analysis Open
Early onset adjacent segment degeneration (ASD) can be found within six months after anterior cervical discectomy and fusion (ACDF). Deficits in deep paraspinal neck muscles may be related to early onset ASD. This study aimed to determine …
View article: Intradiscal Delivery of Anabolic Growth Factors and a Metalloproteinase Inhibitor in a Rabbit Acute Lumbar Disc Injury Model
Intradiscal Delivery of Anabolic Growth Factors and a Metalloproteinase Inhibitor in a Rabbit Acute Lumbar Disc Injury Model Open
A combination of chitosan, TGF-β3, and BMP-4 was effective at promoting regeneration in an acute disc injury rabbit model, whereas TIMP-2 did not have a significant effect.
View article: Image-Based Markers Predict Dynamic Instability in Lumbar Degenerative Spondylolisthesis
Image-Based Markers Predict Dynamic Instability in Lumbar Degenerative Spondylolisthesis Open
In DS patients, preserved DH was significantly related to dynamic instability. This finding may represent a greater potential for slip progression over time in these patients. In contrast, disc degeneration on MRI, and spondylotic changes …
View article: 3D printing in spine surgery
3D printing in spine surgery Open
The applications of three-dimensional (3D) printing, or additive manufacturing, to the field of spine surgery continue to grow in number and scope especially in recent years as improved manufacturing techniques and use of sterilizable mate…
View article: Clinical and CT Analysis of Lumbar Spine Arthrodesis: β-Tricalcium Phosphate Versus Demineralized Bone Matrix
Clinical and CT Analysis of Lumbar Spine Arthrodesis: β-Tricalcium Phosphate Versus Demineralized Bone Matrix Open
No significant difference was found in clinical outcomes at 1 year, with a trend toward a higher fusion rate and lower revision surgery with DBM.
View article: Osteosynthesis of a periprosthetic patella fracture with a locked mesh plate
Osteosynthesis of a periprosthetic patella fracture with a locked mesh plate Open
Periprosthetic patellar fractures continue to be associated with poor functional outcomes and low rates of bony union. We present a patient with a periprosthetic patellar fracture treated with a novel mesh locking plate technique. In thi…
View article: Osteosynthesis of a Periprosthetic Patella Fracture With a Locked Mesh Plate
Osteosynthesis of a Periprosthetic Patella Fracture With a Locked Mesh Plate Open
Periprosthetic patellar fractures continue to be associated with poor functional outcomes and low rates of bony union. We present a patient with a periprosthetic patellar fracture treated with a novel mesh locking plate technique. In this …