Sapir Golan
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View article: Emotional response to amyloid beta status disclosure among research participants at high dementia risk
Emotional response to amyloid beta status disclosure among research participants at high dementia risk Open
INTRODUCTION Amyloid beta (Aβ) can be detected in vivo years before Alzheimer's disease (AD) symptom onset and, according to recent criteria, is sufficient for a biological diagnosis. This study evaluates emotional responses to Aβ status d…
View article: Abdominal Fat Depots are Related to Lower Cognitive Functioning and Brain Volumes in Middle‐aged Males at High Alzheimer’s Risk
Abdominal Fat Depots are Related to Lower Cognitive Functioning and Brain Volumes in Middle‐aged Males at High Alzheimer’s Risk Open
Background High body mass index (BMI), which poorly represents specific fat depots, is linked to poorer cognition and higher dementia risk, with different associations between sexes. We examined associations of abdominal fat depots with co…
View article: Behavioral Reaction to Amyloid β Status Disclosure Among Research Participants with High‐AD Risk in Israel
Behavioral Reaction to Amyloid β Status Disclosure Among Research Participants with High‐AD Risk in Israel Open
Background Amyloid beta (Aβ) deposition marks an early stage in the progression of Alzheimer's disease (AD), detectable in‐vivo years before symptoms emerge and targeted by recently FDA‐approved drugs. This has propelled advancements in un…
View article: Early basal ganglia imaging abnormalities in pre‐symptomatic and early symptomatic novel APP duplication carriers
Early basal ganglia imaging abnormalities in pre‐symptomatic and early symptomatic novel APP duplication carriers Open
Background We aim to describe the imaging findings in pre‐symptomatic and early‐symptomatic individuals carrying a recently described novel APP duplication rearrangement causing early‐onset AD (EOAD). Method We studied individuals from one…
View article: Sex‐specific differences in the association between regional adiposity, cognition, and brain pathology in older adults with Type II Diabetes
Sex‐specific differences in the association between regional adiposity, cognition, and brain pathology in older adults with Type II Diabetes Open
Background While body mass index (BMI) is widely used to gauge overall adiposity, its accuracy in older age has yielded inconsistent findings. Moreover, BMI does not account for variations in regional fat distribution, which may differ bet…
View article: Abdominal fat depots are related to lower cognitive functioning and brain volumes in middle‐aged males at high Alzheimer's risk
Abdominal fat depots are related to lower cognitive functioning and brain volumes in middle‐aged males at high Alzheimer's risk Open
Objective High BMI, which poorly represents specific fat depots, is linked to poorer cognition and higher dementia risk, with different associations between sexes. This study examined associations of abdominal fat depots with cognition and…
View article: Amyloid deposition and small vessel disease are associated with cognitive function in older adults with type 2 diabetes
Amyloid deposition and small vessel disease are associated with cognitive function in older adults with type 2 diabetes Open
View article: Sex modifies the associations of regional fat with cognitive functioning and AD‐related brain volumes, in Israeli middle‐aged adults at high AD risk
Sex modifies the associations of regional fat with cognitive functioning and AD‐related brain volumes, in Israeli middle‐aged adults at high AD risk Open
Background High body mass index (BMI) has been consistently linked to poorer cognition and higher dementia risk, with different associations in males and females. However, BMI does not represent well specific fat depots. We examined in mid…
View article: Differential sex associations of regional adiposity with cognition and brain pathology in Israeli older adults with Type II Diabetes
Differential sex associations of regional adiposity with cognition and brain pathology in Israeli older adults with Type II Diabetes Open
Background Adiposity and Type II diabetes (T2D) are consistently associated with cognitive impairment and dementia. Body mass index (BMI) is the most common measure of global adiposity, but its associations with cognition in old age are in…
View article: Amyloid deposition and small vessel disease are associated with cognitive function in older adults with type 2 diabetes
Amyloid deposition and small vessel disease are associated with cognitive function in older adults with type 2 diabetes Open
Diabetes is associated with cognitive decline, but the underlying mechanisms are complex and their relationship with Alzheimer’s Disease biomarkers is not fully understood. We assessed the association of small vessel disease (SVD) and amyl…
View article: The association between regional adiposity, cognitive function, and dementia-related brain changes: a systematic review
The association between regional adiposity, cognitive function, and dementia-related brain changes: a systematic review Open
Background Adiposity has been previously associated with cognitive impairment and Alzheimer’s disease and related disorders (ADRD). Body mass index (BMI) is the most common measure of global adiposity, but inconsistent results were found s…
View article: Higher proportion of visceral adipose tissue is associated with smaller regional brain volumes in older adults with type 2 diabetes: Triglycerides may be in the pathway
Higher proportion of visceral adipose tissue is associated with smaller regional brain volumes in older adults with type 2 diabetes: Triglycerides may be in the pathway Open
Background Numerous studies have identified an increased risk for Alzheimer’s dementia (AD) in Type II Diabetes (T2D). However, the T2D biological characteristics contributing to this risk are still unknown. Adiposity assessed by body mass…
View article: Alzheimer’s Disease Polygenic Risk Score Is Not Associated With Cognitive Decline Among Older Adults With Type 2 Diabetes
Alzheimer’s Disease Polygenic Risk Score Is Not Associated With Cognitive Decline Among Older Adults With Type 2 Diabetes Open
Objectives Multiple risk loci for late-onset Alzheimer’s disease (LOAD) have been identified. Type 2 diabetes (T2D) is a risk factor for cognitive decline, dementia and Alzheimer’s disease (AD). We investigated the association of polygenic…
View article: Stability in BMI over time is associated with a better cognitive trajectory in older adults
Stability in BMI over time is associated with a better cognitive trajectory in older adults Open
Objective Evidence on simultaneous changes in body mass index (BMI) and cognitive decline, which better reflect the natural course of both health phenomena, is limited. Methods We capitalized on longitudinal data from 15,977 initially non‐…
View article: Sulfonated Amphiphilic Poly(α)glutamate Amine—A Potential siRNA Nanocarrier for the Treatment of Both Chemo-Sensitive and Chemo-Resistant Glioblastoma Tumors
Sulfonated Amphiphilic Poly(α)glutamate Amine—A Potential siRNA Nanocarrier for the Treatment of Both Chemo-Sensitive and Chemo-Resistant Glioblastoma Tumors Open
Development of chemo-resistance is a major challenge in glioblastoma (GB) treatment. This phenomenon is often driven by increased activation of genes associated with DNA repair, such as the alkyl-removing enzyme O6-methylguanine-DNA methyl…
View article: Regional abdominal adiposity is associated with BMI‐related brain regions in middle‐aged adults at high risk of Alzheimer’s dementia
Regional abdominal adiposity is associated with BMI‐related brain regions in middle‐aged adults at high risk of Alzheimer’s dementia Open
Background There is evidence for the involvement of midlife obesity in mild cognitive impairment (MCI), dementia, and Alzheimer’s dementia (AD) risk in late life. Obesity is primarily measured by body mass index (BMI), which poorly reflect…
View article: Amyloid pathology, small‐vessel disease, atrophy, and cognition in normal adults with type 2 diabetes
Amyloid pathology, small‐vessel disease, atrophy, and cognition in normal adults with type 2 diabetes Open
Background Various factors contribute to cognitive decline in older adults with type 2 diabetes (T2D). We assessed the association between imaging metrics of brain pathology (including global atrophy, small vessel disease, and amyloid depo…
View article: P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression
P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression Open
View article: Long‐term trajectories and current BMI are associated with poorer cognitive functioning in middle‐aged adults at high Alzheimer's disease risk
Long‐term trajectories and current BMI are associated with poorer cognitive functioning in middle‐aged adults at high Alzheimer's disease risk Open
Introduction We examined relationships of body mass index (BMI) with cognition in middle‐aged adults at Alzheimer's disease (AD) risk due to parental family history. Methods Participants are offspring of AD patients from the Israel Registr…