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IDH status dictates oHSV mediated metabolic reprogramming affecting anti-tumor immunity Open

Upasana Sahu, Matthew P. Mullarkey, Sara A. Murphy, Joshua C. Anderson, Vasanta Putluri , et al. · 2025

PRMT5 inhibition sensitizes glioblastoma tumor models to temozolomide Open

Shumpei Onishi, Sridharan Jayamohan, Ashis Chowdhury, Sarah Rivas, Yoshihiro Otani , et al. · 2025

Targeting IGF2 to reprogram the tumor microenvironment for enhanced viro-immunotherapy Open

Min Hye Noh, Jin Muk Kang, Alexandra Miller, Grace Nguyen, Minxin Huang , et al. · 2024

Background The FDA approval of oncolytic herpes simplex-1 virus (oHSV) therapy underscores its therapeutic promise and safety as a cancer immunotherapy. Despite this promise, the current efficacy of oHSV is significantly limited to a small…

Supplementary Figure from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy Open

Yoshihiro Otani, Ji Young Yoo, Cole T. Lewis, Samantha Chao, Jessica Swanner , et al. · 2023

Supplementary Figure from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy

Supplementary Data from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy Open

Yoshihiro Otani, Ji Young Yoo, Cole T. Lewis, Samantha Chao, Jessica Swanner , et al. · 2023

Supplementary Data from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy

Data from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy Open

Yoshihiro Otani, Ji Young Yoo, Cole T. Lewis, Samantha Chao, Jessica Swanner , et al. · 2023

Purpose:Oncolytic herpes simplex virus-1 (oHSV) infection of brain tumors activates NOTCH, however the consequences of NOTCH on oHSV-induced immunotherapy is largely unknown. Here we evaluated the impact of NOTCH blockade on virus-induced …

Data from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy Open

Yoshihiro Otani, Ji Young Yoo, Cole T. Lewis, Samantha Chao, Jessica Swanner , et al. · 2023

Purpose:Oncolytic herpes simplex virus-1 (oHSV) infection of brain tumors activates NOTCH, however the consequences of NOTCH on oHSV-induced immunotherapy is largely unknown. Here we evaluated the impact of NOTCH blockade on virus-induced …

Supplementary Data from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy Open

Yoshihiro Otani, Ji Young Yoo, Cole T. Lewis, Samantha Chao, Jessica Swanner , et al. · 2023

Supplementary Data from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy

Supplementary Figure from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy Open

Yoshihiro Otani, Ji Young Yoo, Cole T. Lewis, Samantha Chao, Jessica Swanner , et al. · 2023

Supplementary Figure from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy

Supplementary Data from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy Open

Yoshihiro Otani, Ji Young Yoo, Cole T. Lewis, Samantha Chao, Jessica Swanner , et al. · 2023

Supplementary Data from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy

Supplementary Data from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy Open

Yoshihiro Otani, Ji Young Yoo, Cole T. Lewis, Samantha Chao, Jessica Swanner , et al. · 2023

Supplementary Data from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy

A Bridge to Nowhere: Enabling Autonomy in a Case of Failed ECMO Rescue of Bleomycin-Induced Pulmonary Toxicity Open

James Hall, Michael Khilkin, Sara A. Murphy, George Botros · 2023

Extracorporeal membrane oxygenation (ECMO) can be a life-saving intervention in cases of potentially reversible refractory respiratory failure. One such indication can be bleomycin-induced lung injury. However, in some cases, the injury ca…

EXTH-76. PRMT5 INHIBITION SENSITIZES GLIOBLASTOMA NEUROSPHERES TO TEMOZOLOMIDE Open

Sarah Rivas, Kimberly Rivera-Caraballo, Sara A. Murphy, Yoshihiro Otani, Allison Shelbourn , et al. · 2022

INTRODUCTION The median survival of Glioblastoma (GBM) patients is less than two years with the standard of care of maximal surgical resection, radiation, and temozolomide (TMZ) chemotherapy. Protein Arginine Methyltransferase 5 (PRMT5), w…

EXTH-77. TARGETING CD73 IN GBM SENSITIZES TUMORS TO ONCOLYTIC VIRUS THERAPY Open

Sara A. Murphy, Matthew P. Mullarkey, Upasana Sahu, Bangxing Hong, Cole T. Lewis , et al. · 2022

Glioblastoma Multiforme (GBM) is the most aggressive malignant primary brain tumor and has abysmal 5-year overall survival. With the approval of oHSV Imlygic by FDA for metastatic melanoma and more recently, conditional approval of G47Δ, m…

Histone modifiers at the crossroads of oncolytic and oncogenic viruses Open

Sara A. Murphy, Norman Mapes, Devika Dua, Balveen Kaur · 2022

NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy Open

Yoshihiro Otani, Ji Young Yoo, Cole T. Lewis, Samantha Chao, Jessica Swanner , et al. · 2022

Purpose: Oncolytic herpes simplex virus-1 (oHSV) infection of brain tumors activates NOTCH, however the consequences of NOTCH on oHSV-induced immunotherapy is largely unknown. Here we evaluated the impact of NOTCH blockade on virus-induced…

TAMI-11. IMPACT OF oHSV ACTIVATED NOTCH SIGNALING IN TUMOR MICROENVIRONMENT, AND ITS IMPACT ON ANTI-TUMOR IMMUNITY Open

Yoshihiro Otani, Ji Young Yoo, Samantha Chao, Toshihiko Shimizu, Cole T. Lewis , et al. · 2020

NOTCH signaling is a method of cell-cell communication where membrane bound NOTCH ligands on signal-sending cells can bind to and initiate cleavage of the NOTCH receptor, releasing NICD which can initiate signal transduction in adjacent “s…

ATF3 Coordinates Antitumor Synergy between Epigenetic Drugs and Protein Disulfide Isomerase Inhibitors Open

Ravyn M. Duncan, Leticia Reyes, Katelyn Moats, Reeder M. Robinson, Sara A. Murphy , et al. · 2020

Histone deacetylase inhibitors (HDACi) are largely ineffective in the treatment of solid tumors. In this study, we describe a new class of protein disulfide isomerase (PDI) inhibitors that significantly and synergistically enhance the anti…

<i>PEX1</i> and <i>PEX7</i> Genes are Necessary for Completion of Immune Pathways and Survival Post-Infection Open

Sara A. Murphy · 2020

The innate immune system consists of a variety of different immune pathways including the c-Fos and NF-κB immune pathways and is the first line of an organism’s defence against infection. This research analyzes the role of peroxisomes, an …

Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction Open

Nenja Krüger, Lauren A. Biwer, Miranda E. Good, Claire A. Ruddiman, Abigail G. Wolpe , et al. · 2019

Rationale: Increasing prevalence of obesity and its associated risk with cardiovascular diseases demands a better understanding of the contribution of different cell types within this complex disease for developing new treatment options. P…

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension Open

Isola A.M. Brown, Lukas Diederich, Miranda E. Good, Leon J. DeLalio, Sara A. Murphy , et al. · 2018

Cardiovascular disease is a leading cause of death worldwide and accounts for >17.3 million deaths per year, with an estimated increase in incidence to 23.6 million by 2030. 1 Cardiovascular death represents 31% of all global deaths 2 —wit…

Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure Open

Leon J. DeLalio, Alexander Keller, Jiwang Chen, Andrew K. J. Boyce, Mykhaylo Artamonov , et al. · 2018

Objective— Sympathetic nerve innervation of vascular smooth muscle cells (VSMCs) is a major regulator of arteriolar vasoconstriction, vascular resistance, and blood pressure. Importantly, α–adrenergic receptor stimulation, which uniquely c…

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