Sara Aiman
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View article: Subtractive proteo-genomics and model-based druggability analyses prioritized nitrate reductase-A subunit-α as potential therapeutic target against MDR pneumonia; a homology-based approach
Subtractive proteo-genomics and model-based druggability analyses prioritized nitrate reductase-A subunit-α as potential therapeutic target against MDR pneumonia; a homology-based approach Open
The current study prioritizes several druggable targets against MDR pneumonia, including the nitrate reductase-A subunit-α as a potential alternative target for developing novel anti-pneumonia therapies.
View article: Core-genome-mediated promising alternative drug and multi-epitope vaccine targets prioritization against infectious Clostridium difficile
Core-genome-mediated promising alternative drug and multi-epitope vaccine targets prioritization against infectious Clostridium difficile Open
Prevention of Clostridium difficile infection is challenging worldwide owing to its high morbidity and mortality rates. C . difficile is currently being classified as an urgent threat by the CDC. Devising a new therapeutic strategy become …
View article: Vaccinomics-aided next-generation novel multi-epitope-based vaccine engineering against multidrug resistant Shigella Sonnei: Immunoinformatics and chemoinformatics approaches
Vaccinomics-aided next-generation novel multi-epitope-based vaccine engineering against multidrug resistant Shigella Sonnei: Immunoinformatics and chemoinformatics approaches Open
Shigella sonnei is a gram-negative bacterium and is the primary cause of shigellosis in advanced countries. An exceptional rise in the prevalence of the disease has been reported in Asia, the Middle East, and Latin America. To date, no pre…
View article: Vaccinomics-based next-generation multi-epitope chimeric vaccine models prediction against Leishmania tropica - a hierarchical subtractive proteomics and immunoinformatics approach
Vaccinomics-based next-generation multi-epitope chimeric vaccine models prediction against Leishmania tropica - a hierarchical subtractive proteomics and immunoinformatics approach Open
Leishmania tropica is a vector-borne parasitic protozoa that is the leading cause of leishmaniasis throughout the global tropics and subtropics. L. tropica is a multidrug-resistant parasite with a diverse set of serological, biochemical, a…
View article: A comprehensive protein interaction map and druggability investigation prioritized dengue virus NS1 protein as promising therapeutic candidate
A comprehensive protein interaction map and druggability investigation prioritized dengue virus NS1 protein as promising therapeutic candidate Open
Dengue Virus (DENV) is a serious threat to human life worldwide and is one of the most dangerous vector-borne diseases, causing thousands of deaths annually. We constructed a comprehensive PPI map of DENV with its host Homo sapiens and per…
View article: Annotation of Potential Vaccine Targets and Designing of mRNA-Based Multi-Epitope Vaccine against Lumpy Skin Disease Virus via Reverse Vaccinology and Agent-Based Modeling
Annotation of Potential Vaccine Targets and Designing of mRNA-Based Multi-Epitope Vaccine against Lumpy Skin Disease Virus via Reverse Vaccinology and Agent-Based Modeling Open
Lumpy skin disease is a fatal emerging disease of cattle, which has started to gain extensive attention due to its rapid incursions across the globe. The disease epidemic causes economic loss and cattle morbidity. Currently, there are no s…
View article: Comparative Proteomics and Genome-Wide Druggability Analyses Prioritized Promising Therapeutic Targets against Drug-Resistant Leishmania tropica
Comparative Proteomics and Genome-Wide Druggability Analyses Prioritized Promising Therapeutic Targets against Drug-Resistant Leishmania tropica Open
Leishmania tropica is a tropical parasite causing cutaneous leishmaniasis (CL) in humans. Leishmaniasis is a serious public health threat, affecting an estimated 350 million people in 98 countries. The global rise in antileishmanial drug r…
View article: Molecular Mimicry Analyses Unveiled the Human Herpes Simplex and Poxvirus Epitopes as Possible Candidates to Incite Autoimmunity
Molecular Mimicry Analyses Unveiled the Human Herpes Simplex and Poxvirus Epitopes as Possible Candidates to Incite Autoimmunity Open
Clinical epidemiological studies have reported that viral infections cause autoimmune pathology in humans. Host-pathogen protein sequences and structure-based molecular mimicry cause autoreactive T cells to cross-activate. The aim of the c…
View article: Multi-epitope chimeric vaccine design against emerging Monkeypox virus via reverse vaccinology techniques- a bioinformatics and immunoinformatics approach
Multi-epitope chimeric vaccine design against emerging Monkeypox virus via reverse vaccinology techniques- a bioinformatics and immunoinformatics approach Open
The emerging monkeypox virus (MPXV) is a zoonotic orthopoxvirus that causes infections in humans similar to smallpox. Since May 2022, cases of monkeypox (MPX) have been increasingly reported by the World Health Organization (WHO) worldwide…
View article: Core genome mediated potential vaccine targets prioritization against Clostridium difficile via reverse vaccinology - an immuno-informatics approach
Core genome mediated potential vaccine targets prioritization against Clostridium difficile via reverse vaccinology - an immuno-informatics approach Open
The emergence of multi-drug resistance in clostridium difficile is an urgent bio-threat associated with high morbidity and mortality. The availability of core genome sequences for pathogen strains provides the opportunity to rationally app…
View article: Protein-protein interactions: Methods, databases, and applications in virus-host study
Protein-protein interactions: Methods, databases, and applications in virus-host study Open
Almost all the cellular processes in a living system are controlled by proteins: They regulate gene expression, catalyze chemical reactions, transport small molecules across membranes, and transmit signal across membranes. Even, a viral in…
View article: Inferring Virus-Host relationship between HPV and its host Homo sapiens using protein interaction network
Inferring Virus-Host relationship between HPV and its host Homo sapiens using protein interaction network Open
Human papilloma virus (HPV) is a serious threat to human life globally with over 100 genotypes including cancer causing high risk HPVs. Study on protein interaction maps of pathogens with their host is a recent trend in ‘omics’ era and has…
View article: The In Silico Characterization of a Salicylic Acid Analogue Coding Gene Clusters in Selected <i>Pseudomonas fluorescens</i> Strains.
The In Silico Characterization of a Salicylic Acid Analogue Coding Gene Clusters in Selected <i>Pseudomonas fluorescens</i> Strains. Open
The computational biology and drug discovery analyses identified different gene clusters in P. fluorescens genomes coding for salicylic acid-like chemotypes biosynthesis. These gene clusters may worthy to target through metabolic engineeri…
View article: Species-Wide Genome Mining of Pseudomonas putida for Potential Secondary Metabolites and Drug-Like Natural Products Characterization
Species-Wide Genome Mining of Pseudomonas putida for Potential Secondary Metabolites and Drug-Like Natural Products Characterization Open
The gram negative bacteria species of Pseudomonas putida (P. putida) are important for heterologous expression of diverse biosynthetic pathways and numerous secondary metabolites biosynthesis. The genes code for such secondary metabolites …